SDHAF2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0034553Biological processmitochondrial respiratory chain complex II assembly
GO_0006121Biological processmitochondrial electron transport, succinate to ubiquinone
GO_0006470Biological processprotein dephosphorylation
GO_0010719Biological processnegative regulation of epithelial to mesenchymal transition
GO_0006099Biological processtricarboxylic acid cycle
GO_0018293Biological processprotein-FAD linkage
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0005730Cellular componentnucleolus
GO_0005829Cellular componentcytosol
GO_0005759Cellular componentmitochondrial matrix
GO_0005739Cellular componentmitochondrion
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSDHAF2
Protein nameSuccinate dehydrogenase complex assembly factor 2
Succinate dehydrogenase assembly factor 2, mitochondrial (SDH assembly factor 2) (SDHAF2)
SynonymsPGL2
C11orf79
SDH5
DescriptionFUNCTION: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. .

FUNCTION: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. .

AccessionsENST00000537782.5
M0QY91
Q9NX18
ENST00000301761.7
F5H8E2
M0R060
ENST00000536250.1
ENST00000543265.1
F5H4T4
F5GYJ5
M0QYN2
F8W679
ENST00000543044.2
ENST00000542794.5
ENST00000359614.9
ENST00000534878.5
ENST00000542074.1