Genes | Cell types | No. of supported studies | |
|---|---|---|---|
| Group 1 | 5 studies | ||
| Group 2 | 7 studies | ||
| Group 3 | 6 studies | ||
| Group 4 | 5 studies |
| Name | tricarboxylic acid cycle |
| ID | GO_0006099 |
| collection_id | Biological process |
| Exact synonym | Krebs cycle, TCA cycle, citric acid cycle |
| Description | A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. |
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| Genes |