SDHB | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	20 studies	24% ± 9%	Explore
classical monocyte	18 studies	25% ± 11%	Explore
non-classical monocyte	17 studies	29% ± 14%	Explore
endothelial cell	13 studies	25% ± 8%	Explore
monocyte	12 studies	22% ± 7%	Explore
CD8-positive, alpha-beta T cell	12 studies	22% ± 5%	Explore
conventional dendritic cell	11 studies	30% ± 16%	Explore
natural killer cell	11 studies	21% ± 5%	Explore
regulatory T cell	11 studies	20% ± 4%	Explore
epithelial cell	11 studies	37% ± 17%	Explore
CD4-positive, alpha-beta T cell	10 studies	24% ± 7%	Explore
B cell	9 studies	20% ± 6%	Explore
basal cell	8 studies	30% ± 12%	Explore
fibroblast	8 studies	25% ± 10%	Explore
pericyte	8 studies	20% ± 4%	Explore
plasmacytoid dendritic cell	8 studies	23% ± 8%	Explore
CD16-positive, CD56-dim natural killer cell, human	7 studies	18% ± 2%	Explore
smooth muscle cell	7 studies	25% ± 8%	Explore
dendritic cell	7 studies	34% ± 20%	Explore
ciliated cell	7 studies	31% ± 11%	Explore
memory B cell	7 studies	19% ± 4%	Explore
gamma-delta T cell	7 studies	22% ± 15%	Explore
CD16-negative, CD56-bright natural killer cell, human	6 studies	18% ± 2%	Explore
epithelial cell of proximal tubule	6 studies	32% ± 10%	Explore
enterocyte	6 studies	27% ± 5%	Explore
myeloid cell	6 studies	26% ± 10%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	20% ± 7%	Explore
plasma cell	5 studies	32% ± 12%	Explore
plasmablast	5 studies	42% ± 21%	Explore
secretory cell	5 studies	25% ± 12%	Explore
kidney loop of Henle epithelial cell	5 studies	26% ± 10%	Explore
astrocyte	5 studies	27% ± 4%	Explore
cardiac muscle cell	5 studies	20% ± 3%	Explore
transit amplifying cell	5 studies	22% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	19% ± 2%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	21% ± 5%	Explore
renal alpha-intercalated cell	4 studies	35% ± 12%	Explore
neuron	4 studies	25% ± 10%	Explore
abnormal cell	4 studies	23% ± 12%	Explore
alveolar macrophage	4 studies	18% ± 1%	Explore
erythroblast	4 studies	28% ± 17%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	19% ± 1%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	22% ± 4%	Explore
endothelial cell of vascular tree	4 studies	20% ± 3%	Explore
glutamatergic neuron	4 studies	42% ± 17%	Explore
oligodendrocyte precursor cell	4 studies	27% ± 8%	Explore
oligodendrocyte	4 studies	20% ± 2%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	20% ± 3%	Explore
mucosal invariant T cell	4 studies	16% ± 1%	Explore
pancreatic A cell	3 studies	41% ± 8%	Explore
type B pancreatic cell	3 studies	41% ± 11%	Explore
leukocyte	3 studies	20% ± 6%	Explore
naive B cell	3 studies	19% ± 3%	Explore
mononuclear phagocyte	3 studies	30% ± 13%	Explore
hematopoietic precursor cell	3 studies	31% ± 9%	Explore
mature NK T cell	3 studies	16% ± 1%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	17% ± 1%	Explore
innate lymphoid cell	3 studies	17% ± 1%	Explore
club cell	3 studies	26% ± 8%	Explore
progenitor cell	3 studies	26% ± 3%	Explore
precursor B cell	3 studies	19% ± 2%	Explore
retinal rod cell	3 studies	26% ± 7%	Explore
microglial cell	3 studies	23% ± 6%	Explore
Mueller cell	3 studies	18% ± 2%	Explore
exhausted T cell	3 studies	19% ± 3%	Explore
intermediate monocyte	3 studies	36% ± 15%	Explore
endothelial cell of lymphatic vessel	3 studies	29% ± 9%	Explore
GABAergic neuron	3 studies	43% ± 8%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	23% ± 8%	Explore
pancreatic ductal cell	3 studies	49% ± 21%	Explore
mast cell	3 studies	16% ± 0%	Explore
interneuron	3 studies	31% ± 18%	Explore
double negative thymocyte	3 studies	28% ± 15%	Explore
hepatocyte	3 studies	38% ± 11%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	13 studies	21% ± 7%	Explore
lung	8 studies	26% ± 9%	Explore
kidney	5 studies	23% ± 8%	Explore
brain	5 studies	35% ± 8%	Explore
intestine	5 studies	23% ± 7%	Explore
eye	4 studies	26% ± 7%	Explore
liver	4 studies	28% ± 17%	Explore
pancreas	3 studies	41% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	6324.46	226 / 226	100%	120.66	406 / 406
ovary	100%	1918.94	180 / 180	100%	121.00	430 / 430
pancreas	100%	2155.91	328 / 328	100%	78.57	178 / 178
stomach	100%	3540.81	359 / 359	100%	115.01	286 / 286
uterus	100%	2509.11	170 / 170	100%	111.96	459 / 459
esophagus	100%	3352.88	1444 / 1445	100%	87.67	183 / 183
kidney	100%	6246.58	89 / 89	100%	95.66	900 / 901
skin	100%	3203.99	1806 / 1809	100%	110.50	472 / 472
intestine	100%	4293.68	966 / 966	100%	122.81	526 / 527
breast	100%	3404.71	459 / 459	100%	98.67	1115 / 1118
thymus	100%	2524.39	651 / 653	100%	84.95	604 / 605
bladder	100%	3084.86	21 / 21	99%	110.15	501 / 504
brain	99%	2937.28	2625 / 2642	100%	88.37	705 / 705
lung	99%	2919.58	574 / 578	100%	97.05	1155 / 1155
prostate	100%	2054.08	244 / 245	100%	84.65	500 / 502
adrenal gland	100%	4626.73	258 / 258	98%	71.50	226 / 230
adipose	100%	3494.60	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	122.31	29 / 29
muscle	100%	9430.30	803 / 803	0%	0	0 / 0
spleen	100%	2949.49	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	122.43	45 / 45
ureter	0%	0	0 / 0	100%	41.75	1 / 1
blood vessel	100%	3343.95	1331 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	99%	87.69	79 / 80
heart	98%	7976.89	848 / 861	0%	0	0 / 0
peripheral blood	96%	3300.12	894 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006121	Biological process	mitochondrial electron transport, succinate to ubiquinone
GO_0042776	Biological process	proton motive force-driven mitochondrial ATP synthesis
GO_0022904	Biological process	respiratory electron transport chain
GO_0006099	Biological process	tricarboxylic acid cycle
GO_0009060	Biological process	aerobic respiration
GO_0045273	Cellular component	respiratory chain complex II (succinate dehydrogenase)
GO_0005886	Cellular component	plasma membrane
GO_0005739	Cellular component	mitochondrion
GO_0031966	Cellular component	mitochondrial membrane
GO_0005654	Cellular component	nucleoplasm
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0008177	Molecular function	succinate dehydrogenase (quinone) activity
GO_0009055	Molecular function	electron transfer activity
GO_0046872	Molecular function	metal ion binding
GO_0048039	Molecular function	ubiquinone binding
GO_0051537	Molecular function	2 iron, 2 sulfur cluster binding
GO_0051538	Molecular function	3 iron, 4 sulfur cluster binding
GO_0005515	Molecular function	protein binding
GO_0051539	Molecular function	4 iron, 4 sulfur cluster binding

IV. Literature review

[source]

Gene name	SDHB
Protein name	Succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (EC 1.3.5.1) Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC 1.3.5.1) (Iron-sulfur subunit of complex II) (Ip) Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC 1.3.5.1)
Synonyms	SDH hCG_25123 SDH1
Description	FUNCTION: Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). . FUNCTION: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). .; FUNCTION: Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). . FUNCTION: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). .; FUNCTION: Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). .
Accessions	ENST00000491274.6 ENST00000375499.8 ENST00000463045.3 A0A087WXX8 Q70SX8 P21912 A0A087WWT1

SDHB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review