SDHC | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	21 studies	25% ± 7%	Explore
macrophage	21 studies	26% ± 10%	Explore
endothelial cell	20 studies	28% ± 11%	Explore
fibroblast	20 studies	28% ± 13%	Explore
epithelial cell	19 studies	35% ± 20%	Explore
CD8-positive, alpha-beta T cell	19 studies	28% ± 7%	Explore
pericyte	19 studies	24% ± 8%	Explore
smooth muscle cell	18 studies	24% ± 8%	Explore
ciliated cell	16 studies	40% ± 15%	Explore
regulatory T cell	16 studies	26% ± 8%	Explore
conventional dendritic cell	15 studies	30% ± 14%	Explore
basal cell	15 studies	31% ± 16%	Explore
CD4-positive, alpha-beta T cell	15 studies	26% ± 8%	Explore
classical monocyte	15 studies	25% ± 9%	Explore
B cell	14 studies	23% ± 6%	Explore
T cell	13 studies	26% ± 9%	Explore
non-classical monocyte	13 studies	28% ± 11%	Explore
myofibroblast cell	11 studies	28% ± 9%	Explore
connective tissue cell	11 studies	29% ± 8%	Explore
plasmacytoid dendritic cell	11 studies	32% ± 11%	Explore
gamma-delta T cell	11 studies	27% ± 14%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	25% ± 6%	Explore
mature NK T cell	10 studies	23% ± 5%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	24% ± 6%	Explore
memory B cell	10 studies	22% ± 6%	Explore
endothelial cell of lymphatic vessel	10 studies	29% ± 10%	Explore
plasma cell	9 studies	31% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	9 studies	24% ± 7%	Explore
monocyte	9 studies	22% ± 7%	Explore
naive B cell	9 studies	20% ± 5%	Explore
abnormal cell	9 studies	31% ± 16%	Explore
capillary endothelial cell	8 studies	23% ± 6%	Explore
progenitor cell	8 studies	29% ± 7%	Explore
dendritic cell	8 studies	34% ± 19%	Explore
mucosal invariant T cell	8 studies	23% ± 5%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	7 studies	21% ± 5%	Explore
epithelial cell of proximal tubule	7 studies	44% ± 13%	Explore
goblet cell	7 studies	24% ± 9%	Explore
endothelial cell of vascular tree	7 studies	22% ± 5%	Explore
mast cell	7 studies	21% ± 6%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	28% ± 9%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	29% ± 13%	Explore
kidney loop of Henle epithelial cell	6 studies	39% ± 15%	Explore
renal alpha-intercalated cell	6 studies	53% ± 14%	Explore
vein endothelial cell	6 studies	22% ± 5%	Explore
myeloid cell	6 studies	27% ± 11%	Explore
astrocyte	6 studies	27% ± 14%	Explore
T follicular helper cell	6 studies	21% ± 3%	Explore
type I pneumocyte	5 studies	28% ± 12%	Explore
secretory cell	5 studies	33% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	27% ± 5%	Explore
enterocyte	5 studies	25% ± 6%	Explore
enteroendocrine cell	5 studies	29% ± 11%	Explore
mesothelial cell	5 studies	28% ± 14%	Explore
innate lymphoid cell	5 studies	20% ± 4%	Explore
club cell	5 studies	30% ± 11%	Explore
type II pneumocyte	5 studies	30% ± 16%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	34% ± 11%	Explore
hematopoietic precursor cell	4 studies	36% ± 15%	Explore
plasmablast	4 studies	49% ± 23%	Explore
ionocyte	4 studies	25% ± 7%	Explore
pancreatic A cell	4 studies	33% ± 16%	Explore
exhausted T cell	4 studies	32% ± 5%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	44% ± 7%	Explore
endothelial cell of artery	4 studies	23% ± 4%	Explore
intestinal crypt stem cell	4 studies	26% ± 8%	Explore
retinal ganglion cell	4 studies	52% ± 28%	Explore
erythroblast	4 studies	29% ± 14%	Explore
hematopoietic stem cell	4 studies	26% ± 10%	Explore
pro-B cell	4 studies	24% ± 4%	Explore
precursor B cell	4 studies	28% ± 8%	Explore
alveolar macrophage	4 studies	19% ± 1%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	39% ± 6%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	30% ± 12%	Explore
neuron	4 studies	29% ± 12%	Explore
hepatocyte	4 studies	45% ± 24%	Explore
GABAergic neuron	4 studies	30% ± 9%	Explore
glutamatergic neuron	4 studies	32% ± 12%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	29% ± 9%	Explore
transit amplifying cell	4 studies	19% ± 2%	Explore
interneuron	4 studies	32% ± 19%	Explore
oligodendrocyte	4 studies	19% ± 2%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	23% ± 8%	Explore
duct epithelial cell	3 studies	18% ± 2%	Explore
respiratory goblet cell	3 studies	30% ± 17%	Explore
leukocyte	3 studies	23% ± 6%	Explore
neural crest cell	3 studies	29% ± 4%	Explore
retinal bipolar neuron	3 studies	35% ± 13%	Explore
brush cell	3 studies	28% ± 9%	Explore
neuroendocrine cell	3 studies	32% ± 3%	Explore
immature B cell	3 studies	21% ± 5%	Explore
amacrine cell	3 studies	36% ± 10%	Explore
retina horizontal cell	3 studies	30% ± 14%	Explore
retinal cone cell	3 studies	52% ± 18%	Explore
retinal rod cell	3 studies	31% ± 13%	Explore
microglial cell	3 studies	27% ± 9%	Explore
serous secreting cell	3 studies	20% ± 2%	Explore
Mueller cell	3 studies	25% ± 5%	Explore
germinal center B cell	3 studies	25% ± 2%	Explore
intermediate monocyte	3 studies	33% ± 12%	Explore
pancreatic ductal cell	3 studies	44% ± 7%	Explore
group 3 innate lymphoid cell	3 studies	28% ± 12%	Explore
T-helper 17 cell	3 studies	25% ± 9%	Explore
double negative thymocyte	3 studies	39% ± 18%	Explore
oligodendrocyte precursor cell	3 studies	24% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	13 studies	30% ± 12%	Explore
peripheral blood	11 studies	27% ± 4%	Explore
kidney	9 studies	30% ± 9%	Explore
intestine	8 studies	24% ± 10%	Explore
eye	6 studies	27% ± 13%	Explore
brain	6 studies	26% ± 8%	Explore
liver	5 studies	30% ± 14%	Explore
lymph node	4 studies	25% ± 11%	Explore
pancreas	3 studies	40% ± 12%	Explore
placenta	3 studies	28% ± 18%	Explore
adrenal gland	3 studies	20% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	5046.29	1445 / 1445	100%	79.31	183 / 183
ovary	100%	4025.62	180 / 180	100%	138.50	430 / 430
stomach	100%	3954.15	359 / 359	100%	97.48	286 / 286
brain	100%	5532.84	2642 / 2642	100%	107.13	704 / 705
intestine	100%	4857.60	966 / 966	100%	101.79	526 / 527
uterus	100%	4149.01	170 / 170	100%	113.28	458 / 459
liver	100%	5620.44	226 / 226	100%	148.75	405 / 406
prostate	100%	3888.51	245 / 245	100%	98.63	500 / 502
lung	100%	3577.33	576 / 578	100%	123.71	1154 / 1155
skin	100%	4692.85	1808 / 1809	100%	136.35	470 / 472
breast	100%	3972.68	459 / 459	99%	169.77	1111 / 1118
bladder	100%	4374.81	21 / 21	99%	122.00	500 / 504
thymus	100%	4376.71	653 / 653	99%	86.93	597 / 605
kidney	100%	7897.43	89 / 89	98%	112.90	887 / 901
pancreas	98%	1891.53	323 / 328	99%	87.20	177 / 178
adrenal gland	100%	7534.91	258 / 258	93%	84.32	215 / 230
adipose	100%	4063.40	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	103.42	29 / 29
muscle	100%	8321.00	803 / 803	0%	0	0 / 0
spleen	100%	3862.10	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	108.03	45 / 45
ureter	0%	0	0 / 0	100%	43.81	1 / 1
blood vessel	100%	3874.51	1334 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	99%	96.58	79 / 80
heart	98%	5333.18	846 / 861	0%	0	0 / 0
peripheral blood	92%	3191.29	855 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006121	Biological process	mitochondrial electron transport, succinate to ubiquinone
GO_0009060	Biological process	aerobic respiration
GO_0042776	Biological process	proton motive force-driven mitochondrial ATP synthesis
GO_0006099	Biological process	tricarboxylic acid cycle
GO_0045273	Cellular component	respiratory chain complex II (succinate dehydrogenase)
GO_0016020	Cellular component	membrane
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0005739	Cellular component	mitochondrion
GO_0005515	Molecular function	protein binding
GO_0020037	Molecular function	heme binding
GO_0046872	Molecular function	metal ion binding
GO_0009055	Molecular function	electron transfer activity

IV. Literature review

[source]

Gene name	SDHC
Protein name	Succinate dehydrogenase complex subunit C Succinate dehydrogenase cytochrome b560 subunit, mitochondrial Succinate dehydrogenase cytochrome b560 subunit, mitochondrial (Integral membrane protein CII-3) (QPs-1) (QPs1) (Succinate dehydrogenase complex subunit C) (Succinate-ubiquinone oxidoreductase cytochrome B large subunit) (CYBL)
Synonyms	CYB560 SDH3
Description	FUNCTION: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). FUNCTION: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). . FUNCTION: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). . FUNCTION: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). . FUNCTION: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). . FUNCTION: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). .
Accessions	Q99643 ENST00000513009.5 [Q99643-4] ENST00000342751.8 [Q99643-2] Q6IAQ2 ENST00000470743.5 ENST00000367975.7 [Q99643-1] D6RBX6 A0A0S2Z4B0 A0A0S2Z4B6 A0A087WZU7 ENST00000504963.5 ENST00000432287.6 [Q99643-3] ENST00000392169.6 [Q99643-5] A0A0S2Z4B7 A0A0S2Z4C9

SDHC report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review