Name | Number of supported studies | Average coverage | |
---|---|---|---|
plasmacytoid dendritic cell | 17 studies | 46% ± 16% | |
epithelial cell | 6 studies | 24% ± 6% | |
endothelial cell | 5 studies | 22% ± 8% | |
cardiac muscle cell | 5 studies | 22% ± 4% | |
glutamatergic neuron | 4 studies | 46% ± 19% | |
ciliated cell | 4 studies | 21% ± 4% | |
astrocyte | 4 studies | 30% ± 8% | |
dendritic cell | 4 studies | 35% ± 11% | |
plasmablast | 3 studies | 41% ± 17% | |
conventional dendritic cell | 3 studies | 33% ± 14% | |
non-classical monocyte | 3 studies | 21% ± 4% | |
retinal ganglion cell | 3 studies | 52% ± 25% | |
fibroblast | 3 studies | 19% ± 3% | |
GABAergic neuron | 3 studies | 48% ± 6% | |
basal cell | 3 studies | 19% ± 3% | |
interneuron | 3 studies | 37% ± 21% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 99% | 1443.31 | 1434 / 1445 | 100% | 12.79 | 183 / 183 |
intestine | 100% | 1752.93 | 966 / 966 | 99% | 12.79 | 522 / 527 |
lung | 99% | 1116.05 | 575 / 578 | 99% | 9.83 | 1147 / 1155 |
brain | 99% | 1517.98 | 2625 / 2642 | 99% | 11.89 | 696 / 705 |
stomach | 98% | 886.60 | 352 / 359 | 100% | 13.16 | 286 / 286 |
skin | 100% | 1112.35 | 1807 / 1809 | 98% | 12.83 | 462 / 472 |
breast | 100% | 1048.97 | 459 / 459 | 96% | 8.98 | 1077 / 1118 |
prostate | 100% | 1119.16 | 245 / 245 | 96% | 8.84 | 483 / 502 |
bladder | 100% | 1395.67 | 21 / 21 | 95% | 8.78 | 478 / 504 |
uterus | 100% | 1182.85 | 170 / 170 | 93% | 9.35 | 429 / 459 |
ovary | 100% | 853.63 | 180 / 180 | 92% | 6.59 | 397 / 430 |
kidney | 100% | 1057.75 | 89 / 89 | 92% | 9.51 | 829 / 901 |
thymus | 100% | 870.55 | 652 / 653 | 91% | 6.78 | 550 / 605 |
adrenal gland | 100% | 1934.10 | 258 / 258 | 90% | 11.67 | 207 / 230 |
pancreas | 86% | 399.77 | 283 / 328 | 98% | 6.95 | 174 / 178 |
liver | 71% | 428.73 | 160 / 226 | 76% | 3.95 | 310 / 406 |
adipose | 100% | 1212.24 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 1648.76 | 1335 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 2919.80 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 850.71 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 96% | 10.80 | 43 / 45 |
heart | 93% | 3586.65 | 801 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 90% | 10.18 | 26 / 29 |
eye | 0% | 0 | 0 / 0 | 89% | 6.11 | 71 / 80 |
peripheral blood | 39% | 859.66 | 359 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0005975 | Biological process | carbohydrate metabolic process |
GO_0006099 | Biological process | tricarboxylic acid cycle |
GO_0006102 | Biological process | isocitrate metabolic process |
GO_0005759 | Cellular component | mitochondrial matrix |
GO_0005739 | Cellular component | mitochondrion |
GO_0005634 | Cellular component | nucleus |
GO_0051287 | Molecular function | NAD binding |
GO_0004449 | Molecular function | isocitrate dehydrogenase (NAD+) activity |
GO_0005515 | Molecular function | protein binding |
GO_0000287 | Molecular function | magnesium ion binding |
Gene name | IDH3A |
Protein name | NAD+-dependent isocitrate dehydrogenase 3 alpha subunit Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase subunit alpha) (NAD(+)-specific ICDH subunit alpha) Isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha |
Synonyms | DKFZp686A08194 |
Description | FUNCTION: Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. . FUNCTION: Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. . FUNCTION: Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. . FUNCTION: Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. . FUNCTION: Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. . FUNCTION: Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. . |
Accessions | P50213 ENST00000559881.5 ENST00000557960.1 ENST00000559205.1 ENST00000558933.5 H0YLI6 H0YMY5 ENST00000299518.7 [P50213-1] H0YM64 ENST00000559106.5 A0A0G2JL95 ENST00000558554.5 ENST00000561279.5 H0YNF8 ENST00000559803.5 ENST00000558509.5 H0YM46 ENST00000560396.5 H0YNF5 ENST00000560770.5 ENST00000561366.1 ENST00000629769.2 H0YL05 ENST00000560667.5 H0YL72 ENST00000559186.5 H0YLF8 H0YKD0 H0YMU3 Q9H326 ENST00000557826.5 Q68D72 ENST00000559865.5 |