OGDHL report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006103Biological process2-oxoglutarate metabolic process
GO_0006099Biological processtricarboxylic acid cycle
GO_0006096Biological processglycolytic process
GO_0045252Cellular componentoxoglutarate dehydrogenase complex
GO_0005759Cellular componentmitochondrial matrix
GO_0005739Cellular componentmitochondrion
GO_0030976Molecular functionthiamine pyrophosphate binding
GO_0004591Molecular functionoxoglutarate dehydrogenase (succinyl-transferring) activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameOGDHL
Protein name2-oxoglutarate dehydrogenase-like, mitochondrial (EC 1.2.4.2) (2-oxoglutarate dehydrogenase complex component E1-like) (OGDC-E1-like) (Alpha-ketoglutarate dehydrogenase-like)
SynonymsKIAA1290
DescriptionFUNCTION: 2-oxoglutarate dehydrogenase (E1-like) component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDHC) which mediates the decarboxylation of alpha-ketoglutarate in the tricarboxylic acid cycle. The OGDHC complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) while reducing NAD(+) to NADH (By similarity). The OGDHC complex is mainly active in the mitochondrion (By similarity). Involved in the inhibition of cell proliferation and in apoptosis . .

AccessionsENST00000432695.2 [Q9ULD0-3]
ENST00000374103.9 [Q9ULD0-1]
ENST00000419399.4 [Q9ULD0-2]
Q9ULD0