SDHA | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
CD8-positive, alpha-beta T cell	16 studies	22% ± 6%	Explore
natural killer cell	15 studies	22% ± 6%	Explore
regulatory T cell	14 studies	21% ± 4%	Explore
CD4-positive, alpha-beta T cell	12 studies	21% ± 3%	Explore
endothelial cell	11 studies	24% ± 6%	Explore
T cell	10 studies	20% ± 5%	Explore
ciliated cell	9 studies	27% ± 10%	Explore
B cell	9 studies	20% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	20% ± 3%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	23% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	8 studies	23% ± 5%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	8 studies	20% ± 3%	Explore
fibroblast	8 studies	24% ± 9%	Explore
gamma-delta T cell	8 studies	26% ± 9%	Explore
mature NK T cell	7 studies	19% ± 3%	Explore
epithelial cell	7 studies	43% ± 17%	Explore
memory B cell	7 studies	16% ± 1%	Explore
plasma cell	6 studies	30% ± 10%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	19% ± 3%	Explore
basal cell	6 studies	27% ± 12%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	6 studies	19% ± 1%	Explore
epithelial cell of proximal tubule	6 studies	20% ± 4%	Explore
enterocyte	6 studies	24% ± 5%	Explore
abnormal cell	6 studies	24% ± 5%	Explore
mucosal invariant T cell	6 studies	22% ± 2%	Explore
pericyte	6 studies	19% ± 3%	Explore
cardiac muscle cell	6 studies	31% ± 5%	Explore
plasmacytoid dendritic cell	6 studies	21% ± 6%	Explore
plasmablast	5 studies	43% ± 21%	Explore
conventional dendritic cell	5 studies	25% ± 10%	Explore
kidney loop of Henle epithelial cell	5 studies	22% ± 3%	Explore
transit amplifying cell	5 studies	20% ± 1%	Explore
retinal ganglion cell	5 studies	64% ± 27%	Explore
smooth muscle cell	5 studies	21% ± 5%	Explore
type I pneumocyte	5 studies	21% ± 3%	Explore
oligodendrocyte	5 studies	23% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	25% ± 3%	Explore
exhausted T cell	4 studies	24% ± 7%	Explore
renal alpha-intercalated cell	4 studies	36% ± 4%	Explore
neuron	4 studies	26% ± 9%	Explore
pro-B cell	4 studies	32% ± 7%	Explore
myofibroblast cell	4 studies	20% ± 3%	Explore
retina horizontal cell	4 studies	39% ± 7%	Explore
retinal cone cell	4 studies	28% ± 7%	Explore
retinal rod cell	4 studies	20% ± 4%	Explore
progenitor cell	4 studies	18% ± 3%	Explore
GABAergic neuron	4 studies	36% ± 18%	Explore
glutamatergic neuron	4 studies	41% ± 22%	Explore
naive B cell	4 studies	20% ± 3%	Explore
interneuron	4 studies	30% ± 20%	Explore
hematopoietic precursor cell	3 studies	27% ± 10%	Explore
secretory cell	3 studies	23% ± 4%	Explore
classical monocyte	3 studies	25% ± 7%	Explore
non-classical monocyte	3 studies	25% ± 8%	Explore
lymphocyte	3 studies	19% ± 3%	Explore
club cell	3 studies	19% ± 3%	Explore
precursor B cell	3 studies	32% ± 6%	Explore
amacrine cell	3 studies	30% ± 6%	Explore
macrophage	3 studies	21% ± 4%	Explore
astrocyte	3 studies	26% ± 7%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	24% ± 6%	Explore
oligodendrocyte precursor cell	3 studies	32% ± 3%	Explore
goblet cell	3 studies	26% ± 2%	Explore
T follicular helper cell	3 studies	19% ± 2%	Explore
brush cell	3 studies	18% ± 2%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	17% ± 1%	Explore
hepatocyte	3 studies	40% ± 14%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	11 studies	20% ± 5%	Explore
lung	7 studies	21% ± 5%	Explore
kidney	6 studies	19% ± 1%	Explore
brain	6 studies	31% ± 14%	Explore
intestine	6 studies	21% ± 6%	Explore
eye	5 studies	22% ± 5%	Explore
heart	3 studies	19% ± 2%	Explore
liver	3 studies	32% ± 15%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	13393.41	258 / 258	100%	3.01	230 / 230
ovary	100%	6682.22	180 / 180	100%	3.82	430 / 430
kidney	100%	9961.34	89 / 89	100%	5.11	900 / 901
intestine	100%	10000.30	965 / 966	100%	5.41	526 / 527
stomach	100%	7802.87	359 / 359	100%	4.57	285 / 286
liver	100%	10319.94	226 / 226	100%	4.17	404 / 406
esophagus	100%	6981.50	1445 / 1445	99%	4.57	182 / 183
breast	100%	6614.47	459 / 459	99%	2.80	1111 / 1118
uterus	100%	5551.28	170 / 170	99%	3.79	454 / 459
bladder	100%	6398.48	21 / 21	98%	4.15	496 / 504
brain	98%	6343.61	2601 / 2642	99%	2.48	697 / 705
prostate	100%	4478.15	244 / 245	97%	2.23	486 / 502
lung	99%	5831.63	573 / 578	97%	2.89	1122 / 1155
pancreas	97%	3174.16	319 / 328	98%	3.08	175 / 178
skin	100%	6425.79	1808 / 1809	94%	2.29	446 / 472
thymus	100%	5281.51	651 / 653	86%	1.71	521 / 605
adipose	100%	6877.90	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	2.99	29 / 29
muscle	100%	21984.05	803 / 803	0%	0	0 / 0
spleen	100%	6103.33	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	3.63	1 / 1
blood vessel	100%	5743.67	1333 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	99%	4.03	79 / 80
heart	98%	25701.86	847 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	2.49	44 / 45
peripheral blood	80%	4331.19	739 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006121	Biological process	mitochondrial electron transport, succinate to ubiquinone
GO_0006105	Biological process	succinate metabolic process
GO_0022904	Biological process	respiratory electron transport chain
GO_0042776	Biological process	proton motive force-driven mitochondrial ATP synthesis
GO_0007399	Biological process	nervous system development
GO_0006099	Biological process	tricarboxylic acid cycle
GO_0045273	Cellular component	respiratory chain complex II (succinate dehydrogenase)
GO_0005730	Cellular component	nucleolus
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0005739	Cellular component	mitochondrion
GO_0008177	Molecular function	succinate dehydrogenase (quinone) activity
GO_0000104	Molecular function	succinate dehydrogenase activity
GO_0005515	Molecular function	protein binding
GO_0050660	Molecular function	flavin adenine dinucleotide binding
GO_0009055	Molecular function	electron transfer activity

IV. Literature review

[source]

Gene name	SDHA
Protein name	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC 1.3.5.1) Succinate dehydrogenase complex flavoprotein subunit A succinate dehydrogenase (EC 1.3.5.1) Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC 1.3.5.1) (Flavoprotein subunit of complex II) (Fp)
Synonyms	SDHF SDH2
Description	FUNCTION: Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) . Can act as a tumor suppressor . . FUNCTION: Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). .
Accessions	H0Y8S2 P31040 ENST00000504309.5 ENST00000515815.5 ENST00000509632.5 ENST00000509564.1 Q0QF12 D6RFM5 ENST00000264932.11 [P31040-1] H0Y8X1 ENST00000510361.5 [P31040-2] D6REB7

SDHA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review