SDHD | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	21 studies	27% ± 13%	Explore
smooth muscle cell	19 studies	23% ± 9%	Explore
endothelial cell	17 studies	26% ± 11%	Explore
pericyte	17 studies	25% ± 9%	Explore
natural killer cell	16 studies	23% ± 6%	Explore
non-classical monocyte	15 studies	27% ± 12%	Explore
basal cell	14 studies	29% ± 14%	Explore
B cell	14 studies	22% ± 7%	Explore
CD4-positive, alpha-beta T cell	14 studies	22% ± 5%	Explore
macrophage	14 studies	27% ± 10%	Explore
CD8-positive, alpha-beta T cell	13 studies	24% ± 4%	Explore
endothelial cell of lymphatic vessel	12 studies	26% ± 9%	Explore
conventional dendritic cell	12 studies	30% ± 16%	Explore
epithelial cell	11 studies	35% ± 19%	Explore
myofibroblast cell	10 studies	25% ± 10%	Explore
connective tissue cell	10 studies	25% ± 10%	Explore
regulatory T cell	10 studies	22% ± 3%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	21% ± 5%	Explore
classical monocyte	9 studies	28% ± 10%	Explore
monocyte	8 studies	24% ± 5%	Explore
gamma-delta T cell	8 studies	25% ± 13%	Explore
mast cell	8 studies	18% ± 2%	Explore
CD16-negative, CD56-bright natural killer cell, human	7 studies	20% ± 2%	Explore
epithelial cell of proximal tubule	7 studies	41% ± 12%	Explore
mature NK T cell	7 studies	20% ± 3%	Explore
T cell	7 studies	21% ± 3%	Explore
enterocyte	7 studies	26% ± 8%	Explore
memory B cell	7 studies	20% ± 3%	Explore
endothelial cell of vascular tree	7 studies	22% ± 4%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	21% ± 4%	Explore
secretory cell	6 studies	26% ± 11%	Explore
capillary endothelial cell	6 studies	20% ± 4%	Explore
kidney loop of Henle epithelial cell	6 studies	42% ± 12%	Explore
progenitor cell	6 studies	23% ± 7%	Explore
renal alpha-intercalated cell	6 studies	50% ± 15%	Explore
dendritic cell	6 studies	37% ± 18%	Explore
myeloid cell	6 studies	28% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	5 studies	18% ± 2%	Explore
goblet cell	5 studies	26% ± 12%	Explore
CD16-positive, CD56-dim natural killer cell, human	5 studies	20% ± 1%	Explore
mucosal invariant T cell	5 studies	19% ± 1%	Explore
innate lymphoid cell	5 studies	19% ± 2%	Explore
ciliated cell	5 studies	37% ± 7%	Explore
plasmacytoid dendritic cell	5 studies	26% ± 6%	Explore
hematopoietic precursor cell	4 studies	28% ± 6%	Explore
plasma cell	4 studies	35% ± 12%	Explore
plasmablast	4 studies	44% ± 22%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	21% ± 4%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	36% ± 16%	Explore
intestinal crypt stem cell	4 studies	27% ± 9%	Explore
naive B cell	4 studies	20% ± 2%	Explore
erythroblast	4 studies	30% ± 15%	Explore
alveolar macrophage	4 studies	22% ± 4%	Explore
vein endothelial cell	4 studies	19% ± 4%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	23% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	28% ± 9%	Explore
T follicular helper cell	4 studies	19% ± 2%	Explore
transit amplifying cell	4 studies	21% ± 3%	Explore
glomerular endothelial cell	3 studies	26% ± 7%	Explore
leukocyte	3 studies	22% ± 6%	Explore
abnormal cell	3 studies	28% ± 10%	Explore
club cell	3 studies	25% ± 8%	Explore
mesothelial cell	3 studies	33% ± 20%	Explore
germinal center B cell	3 studies	21% ± 4%	Explore
intermediate monocyte	3 studies	28% ± 13%	Explore
type I pneumocyte	3 studies	29% ± 9%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	21% ± 3%	Explore
hepatocyte	3 studies	40% ± 28%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	9 studies	24% ± 5%	Explore
lung	9 studies	29% ± 12%	Explore
intestine	8 studies	24% ± 11%	Explore
kidney	7 studies	29% ± 8%	Explore
uterus	4 studies	26% ± 8%	Explore
brain	4 studies	27% ± 10%	Explore
eye	3 studies	19% ± 2%	Explore
thymus	3 studies	29% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3710.06	1445 / 1445	100%	78.00	183 / 183
ovary	100%	2804.39	180 / 180	100%	104.80	430 / 430
uterus	100%	3161.98	170 / 170	100%	58.11	458 / 459
kidney	100%	6888.42	89 / 89	100%	76.81	899 / 901
liver	100%	5749.39	226 / 226	100%	70.72	405 / 406
lung	100%	2875.58	577 / 578	100%	67.74	1154 / 1155
thymus	100%	3756.56	653 / 653	100%	69.42	603 / 605
brain	99%	2059.53	2624 / 2642	100%	52.07	705 / 705
bladder	100%	3834.81	21 / 21	99%	59.68	500 / 504
breast	100%	3601.14	459 / 459	99%	52.29	1109 / 1118
prostate	100%	2859.72	245 / 245	99%	52.73	497 / 502
adrenal gland	100%	3501.24	258 / 258	99%	45.90	227 / 230
stomach	100%	3113.77	359 / 359	98%	74.89	280 / 286
pancreas	98%	1542.73	321 / 328	100%	50.50	178 / 178
intestine	100%	5006.59	966 / 966	97%	70.05	512 / 527
skin	100%	3090.80	1807 / 1809	96%	42.67	453 / 472
adipose	100%	3890.47	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	77.74	29 / 29
muscle	100%	6620.75	803 / 803	0%	0	0 / 0
spleen	100%	2954.33	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	45.07	45 / 45
ureter	0%	0	0 / 0	100%	22.92	1 / 1
blood vessel	100%	3008.29	1333 / 1335	0%	0	0 / 0
heart	98%	4715.78	840 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	95%	34.80	76 / 80
peripheral blood	90%	2146.55	839 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006121	Biological process	mitochondrial electron transport, succinate to ubiquinone
GO_0042776	Biological process	proton motive force-driven mitochondrial ATP synthesis
GO_0050433	Biological process	regulation of catecholamine secretion
GO_0006099	Biological process	tricarboxylic acid cycle
GO_0071456	Biological process	cellular response to hypoxia
GO_0005740	Cellular component	mitochondrial envelope
GO_0045273	Cellular component	respiratory chain complex II (succinate dehydrogenase)
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0005739	Cellular component	mitochondrion
GO_0048039	Molecular function	ubiquinone binding
GO_0008177	Molecular function	succinate dehydrogenase (quinone) activity
GO_0020037	Molecular function	heme binding
GO_0005515	Molecular function	protein binding
GO_0046872	Molecular function	metal ion binding
GO_0009055	Molecular function	electron transfer activity

IV. Literature review

[source]

Gene name	SDHD
Protein name	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial (CybS) (CII-4) (QPs3) (Succinate dehydrogenase complex subunit D) (Succinate-ubiquinone oxidoreductase cytochrome b small subunit) (Succinate-ubiquinone reductase membrane anchor subunit) Succinate dehydrogenase complex subunit D Succinate dehydrogenase complex subunit D integral membrane protein isoform 2 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit
Synonyms	SDH4 hCG_2032955
Description	FUNCTION: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). . FUNCTION: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). . FUNCTION: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). . FUNCTION: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). . FUNCTION: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). .
Accessions	E9PK73 A0A1W2PNY0 ENST00000640554.1 ENST00000525291.5 [O14521-2] O14521 G3V173 ENST00000530923.6 H0YD96 ENST00000528182.5 ENST00000534010.2 ENST00000528021.6 ENST00000526592.5 [O14521-4] A0A0S2Z4H7 ENST00000528048.5 [O14521-3] A0A0S2Z4J3 ENST00000375549.8 [O14521-1]

SDHD report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review