IREB2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006101Biological processcitrate metabolic process
GO_0009791Biological processpost-embryonic development
GO_0030316Biological processosteoclast differentiation
GO_0060586Biological processmulticellular organismal-level iron ion homeostasis
GO_0048255Biological processmRNA stabilization
GO_0051649Biological processestablishment of localization in cell
GO_0006417Biological processregulation of translation
GO_0034101Biological processerythrocyte homeostasis
GO_0006879Biological processintracellular iron ion homeostasis
GO_0050892Biological processintestinal absorption
GO_0006099Biological processtricarboxylic acid cycle
GO_0006782Biological processprotoporphyrinogen IX biosynthetic process
GO_0005739Cellular componentmitochondrion
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0003994Molecular functionaconitate hydratase activity
GO_0046872Molecular functionmetal ion binding
GO_0003723Molecular functionRNA binding
GO_0030350Molecular functioniron-responsive element binding
GO_0005515Molecular functionprotein binding
GO_0051539Molecular function4 iron, 4 sulfur cluster binding

IV. Literature review

[source]
Gene nameIREB2
Protein nameIron responsive element binding protein 2
Iron-responsive element-binding protein 2 (IRE-BP 2) (Iron regulatory protein 2) (IRP2)
Synonyms
DescriptionFUNCTION: RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. .

AccessionsENST00000560440.5 [P48200-2]
ENST00000559091.1
ENST00000560840.5
H0YLE0
H0YMA8
ENST00000558570.5
ENST00000559215.5
H0YL48
H0YN46
H0YNL8
ENST00000258886.13 [P48200-1]
P48200
ENST00000558525.5