PDHB | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	12 studies	19% ± 3%	Explore
pericyte	12 studies	21% ± 5%	Explore
endothelial cell	9 studies	26% ± 10%	Explore
fibroblast	9 studies	28% ± 12%	Explore
smooth muscle cell	9 studies	23% ± 5%	Explore
basal cell	7 studies	31% ± 18%	Explore
myofibroblast cell	6 studies	19% ± 2%	Explore
connective tissue cell	6 studies	21% ± 5%	Explore
plasmacytoid dendritic cell	6 studies	22% ± 6%	Explore
CD16-negative, CD56-bright natural killer cell, human	5 studies	19% ± 3%	Explore
renal alpha-intercalated cell	5 studies	33% ± 12%	Explore
epithelial cell	5 studies	41% ± 14%	Explore
endothelial cell of lymphatic vessel	5 studies	22% ± 6%	Explore
neuron	5 studies	30% ± 13%	Explore
ciliated cell	5 studies	35% ± 14%	Explore
regulatory T cell	5 studies	18% ± 4%	Explore
ionocyte	4 studies	25% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	4 studies	21% ± 3%	Explore
CD8-positive, alpha-beta T cell	4 studies	21% ± 4%	Explore
classical monocyte	4 studies	22% ± 7%	Explore
conventional dendritic cell	4 studies	31% ± 14%	Explore
non-classical monocyte	4 studies	25% ± 8%	Explore
epithelial cell of proximal tubule	4 studies	19% ± 2%	Explore
kidney loop of Henle epithelial cell	4 studies	28% ± 9%	Explore
B cell	4 studies	23% ± 8%	Explore
CD4-positive, alpha-beta T cell	4 studies	19% ± 5%	Explore
goblet cell	4 studies	23% ± 7%	Explore
secretory cell	3 studies	32% ± 20%	Explore
pancreatic A cell	3 studies	34% ± 10%	Explore
type B pancreatic cell	3 studies	38% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	18% ± 2%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	20% ± 4%	Explore
endothelial cell of artery	3 studies	17% ± 1%	Explore
club cell	3 studies	21% ± 5%	Explore
pro-B cell	3 studies	25% ± 4%	Explore
retina horizontal cell	3 studies	30% ± 19%	Explore
erythroblast	3 studies	28% ± 13%	Explore
GABAergic neuron	3 studies	24% ± 3%	Explore
glutamatergic neuron	3 studies	30% ± 4%	Explore
dendritic cell	3 studies	37% ± 10%	Explore
oligodendrocyte precursor cell	3 studies	29% ± 10%	Explore
enteroendocrine cell	3 studies	29% ± 13%	Explore
intestinal crypt stem cell	3 studies	21% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	5 studies	31% ± 16%	Explore
brain	5 studies	22% ± 5%	Explore
peripheral blood	4 studies	23% ± 5%	Explore
pancreas	3 studies	36% ± 11%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3660.19	1445 / 1445	100%	16.40	183 / 183
liver	100%	2340.98	226 / 226	100%	28.30	406 / 406
ovary	100%	1504.82	180 / 180	100%	30.67	430 / 430
stomach	100%	2693.28	359 / 359	100%	26.90	286 / 286
uterus	100%	2382.07	170 / 170	100%	29.60	459 / 459
skin	100%	2795.85	1808 / 1809	100%	33.02	472 / 472
kidney	100%	3355.26	89 / 89	100%	27.14	900 / 901
brain	100%	2729.77	2637 / 2642	100%	40.21	705 / 705
bladder	100%	2655.24	21 / 21	100%	29.33	503 / 504
thymus	100%	2357.79	652 / 653	100%	30.63	604 / 605
breast	100%	2797.37	459 / 459	100%	37.41	1114 / 1118
intestine	100%	3185.25	966 / 966	100%	31.51	525 / 527
adrenal gland	100%	4641.57	258 / 258	100%	32.75	229 / 230
lung	99%	2274.90	574 / 578	100%	24.23	1155 / 1155
prostate	100%	2309.33	245 / 245	99%	34.45	498 / 502
pancreas	97%	1291.46	317 / 328	100%	24.73	178 / 178
adipose	100%	3103.05	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	19.93	80 / 80
lymph node	0%	0	0 / 0	100%	36.85	29 / 29
muscle	100%	6419.06	803 / 803	0%	0	0 / 0
spleen	100%	2844.10	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	26.55	45 / 45
ureter	0%	0	0 / 0	100%	12.87	1 / 1
blood vessel	100%	3214.60	1334 / 1335	0%	0	0 / 0
heart	98%	5345.38	845 / 861	0%	0	0 / 0
peripheral blood	84%	1499.02	776 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006086	Biological process	acetyl-CoA biosynthetic process from pyruvate
GO_0006006	Biological process	glucose metabolic process
GO_0006099	Biological process	tricarboxylic acid cycle
GO_0045254	Cellular component	pyruvate dehydrogenase complex
GO_0005654	Cellular component	nucleoplasm
GO_0005759	Cellular component	mitochondrial matrix
GO_0005739	Cellular component	mitochondrion
GO_0005634	Cellular component	nucleus
GO_0034604	Molecular function	pyruvate dehydrogenase (NAD+) activity
GO_0005515	Molecular function	protein binding
GO_0004739	Molecular function	pyruvate dehydrogenase (acetyl-transferring) activity

IV. Literature review

[source]

Gene name	PDHB
Protein name	Pyruvate dehydrogenase E1 component subunit beta (EC 1.2.4.1) Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHE1-B) (EC 1.2.4.1)
Synonyms	PHE1B
Description	FUNCTION: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. . FUNCTION: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. .; FUNCTION: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. . FUNCTION: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. .; FUNCTION: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. .
Accessions	ENST00000469364.5 P11177 ENST00000485460.5 [P11177-3] ENST00000474765.1 ENST00000302746.11 [P11177-1] C9J634 ENST00000383714.8 [P11177-2] F8WF02

PDHB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review