DLST report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0033512Biological processL-lysine catabolic process to acetyl-CoA via saccharopine
GO_0006091Biological processgeneration of precursor metabolites and energy
GO_0006103Biological process2-oxoglutarate metabolic process
GO_0006099Biological processtricarboxylic acid cycle
GO_0006104Biological processsuccinyl-CoA metabolic process
GO_0045252Cellular componentoxoglutarate dehydrogenase complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005759Cellular componentmitochondrial matrix
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0005634Cellular componentnucleus
GO_0004149Molecular functiondihydrolipoyllysine-residue succinyltransferase activity
GO_0016746Molecular functionacyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDLST
Protein nameDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex (EC 2.3.1.-)
Dihydrolipoamide S-succinyltransferase
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex component E2) (OGDC-E2) (Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex) (E2K)
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (EC 2.3.1.61) (E2K)
Dihydrolipoamide S-succinyltransferase (cDNA, FLJ79362, moderately similar to Dihydrolipoyllysine-residue succinyltransferase component of 2- oxoglutarate dehydrogenase complex, mitochondrial)
SynonymsDLTS
hCG_22359
DescriptionFUNCTION: Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion . A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A . .

AccessionsG3V5M3
ENST00000555988.1
Q86TQ8
ENST00000334220.9 [P36957-1]
ENST00000238671.11
ENST00000554806.5
Q86SW4
G3V3F0
Q6IBS5
H0YJF9
P36957
ENST00000626051.1
ENST00000555089.5
ENST00000554612.5
ENST00000555492.5
Q86TW7
G3V5L9
G3V498
ENST00000556460.5
B7ZAZ8