Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 6 studies | 25% ± 3% | |
| epithelial cell | 6 studies | 27% ± 9% | |
| fibroblast | 5 studies | 21% ± 4% | |
| glutamatergic neuron | 4 studies | 34% ± 16% | |
| natural killer cell | 3 studies | 18% ± 2% | |
| GABAergic neuron | 3 studies | 33% ± 11% | |
| astrocyte | 3 studies | 22% ± 6% | |
| basal cell | 3 studies | 26% ± 7% | |
| goblet cell | 3 studies | 25% ± 11% | |
| transit amplifying cell | 3 studies | 27% ± 8% | |
| interneuron | 3 studies | 28% ± 16% | |
| neuron | 3 studies | 23% ± 3% | |
| plasmacytoid dendritic cell | 3 studies | 21% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 8155.62 | 1445 / 1445 | 100% | 60.14 | 183 / 183 |
| kidney | 100% | 9234.62 | 89 / 89 | 100% | 91.48 | 901 / 901 |
| lung | 100% | 6924.38 | 578 / 578 | 100% | 73.45 | 1155 / 1155 |
| prostate | 100% | 5937.49 | 245 / 245 | 100% | 69.68 | 502 / 502 |
| stomach | 100% | 6181.77 | 359 / 359 | 100% | 64.84 | 286 / 286 |
| skin | 100% | 9603.82 | 1809 / 1809 | 100% | 88.67 | 471 / 472 |
| bladder | 100% | 7988.81 | 21 / 21 | 100% | 72.88 | 502 / 504 |
| uterus | 100% | 6999.01 | 170 / 170 | 100% | 77.64 | 457 / 459 |
| breast | 100% | 8477.17 | 459 / 459 | 100% | 74.66 | 1113 / 1118 |
| thymus | 100% | 6396.63 | 653 / 653 | 99% | 85.93 | 601 / 605 |
| liver | 100% | 5490.79 | 226 / 226 | 99% | 59.73 | 403 / 406 |
| intestine | 100% | 8331.44 | 966 / 966 | 99% | 79.70 | 523 / 527 |
| pancreas | 100% | 3417.91 | 327 / 328 | 99% | 74.67 | 177 / 178 |
| ovary | 100% | 6042.82 | 180 / 180 | 99% | 54.52 | 426 / 430 |
| adrenal gland | 100% | 11086.23 | 258 / 258 | 98% | 60.10 | 225 / 230 |
| brain | 97% | 3509.45 | 2570 / 2642 | 100% | 64.96 | 705 / 705 |
| adipose | 100% | 8791.99 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 6852.34 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 67.44 | 29 / 29 |
| muscle | 100% | 10864.38 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 6233.90 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 85.86 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 32.86 | 1 / 1 |
| eye | 0% | 0 | 0 / 0 | 99% | 73.05 | 79 / 80 |
| heart | 99% | 9312.16 | 850 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 94% | 4276.26 | 871 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0033512 | Biological process | L-lysine catabolic process to acetyl-CoA via saccharopine |
| GO_0006091 | Biological process | generation of precursor metabolites and energy |
| GO_0006103 | Biological process | 2-oxoglutarate metabolic process |
| GO_0006099 | Biological process | tricarboxylic acid cycle |
| GO_0006104 | Biological process | succinyl-CoA metabolic process |
| GO_0045252 | Cellular component | oxoglutarate dehydrogenase complex |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0005759 | Cellular component | mitochondrial matrix |
| GO_0016020 | Cellular component | membrane |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0005634 | Cellular component | nucleus |
| GO_0004149 | Molecular function | dihydrolipoyllysine-residue succinyltransferase activity |
| GO_0016746 | Molecular function | acyltransferase activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | DLST |
| Protein name | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex (EC 2.3.1.-) Dihydrolipoamide S-succinyltransferase Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex component E2) (OGDC-E2) (Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex) (E2K) Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (EC 2.3.1.61) (E2K) Dihydrolipoamide S-succinyltransferase (cDNA, FLJ79362, moderately similar to Dihydrolipoyllysine-residue succinyltransferase component of 2- oxoglutarate dehydrogenase complex, mitochondrial) |
| Synonyms | DLTS hCG_22359 |
| Description | FUNCTION: Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion . A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A . . |
| Accessions | G3V5M3 ENST00000555988.1 Q86TQ8 ENST00000334220.9 [P36957-1] ENST00000238671.11 ENST00000554806.5 Q86SW4 G3V3F0 Q6IBS5 H0YJF9 P36957 ENST00000626051.1 ENST00000555089.5 ENST00000554612.5 ENST00000555492.5 Q86TW7 G3V5L9 G3V498 ENST00000556460.5 B7ZAZ8 |