IDH2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	28 studies	31% ± 14%	Explore
CD8-positive, alpha-beta T cell	27 studies	34% ± 15%	Explore
T cell	22 studies	33% ± 16%	Explore
conventional dendritic cell	19 studies	33% ± 12%	Explore
CD4-positive, alpha-beta T cell	17 studies	29% ± 12%	Explore
macrophage	17 studies	27% ± 11%	Explore
regulatory T cell	16 studies	24% ± 7%	Explore
mature NK T cell	14 studies	26% ± 6%	Explore
plasma cell	14 studies	41% ± 17%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	28% ± 7%	Explore
gamma-delta T cell	14 studies	32% ± 16%	Explore
B cell	13 studies	27% ± 11%	Explore
ciliated cell	12 studies	39% ± 15%	Explore
epithelial cell	12 studies	39% ± 14%	Explore
non-classical monocyte	12 studies	32% ± 12%	Explore
fibroblast	12 studies	26% ± 8%	Explore
plasmablast	11 studies	48% ± 21%	Explore
endothelial cell	11 studies	30% ± 14%	Explore
plasmacytoid dendritic cell	11 studies	27% ± 10%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	34% ± 16%	Explore
monocyte	10 studies	26% ± 6%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	26% ± 4%	Explore
smooth muscle cell	10 studies	32% ± 12%	Explore
pericyte	9 studies	35% ± 15%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	27% ± 8%	Explore
myofibroblast cell	8 studies	27% ± 10%	Explore
progenitor cell	8 studies	40% ± 11%	Explore
connective tissue cell	8 studies	33% ± 12%	Explore
abnormal cell	8 studies	30% ± 7%	Explore
astrocyte	8 studies	29% ± 14%	Explore
dendritic cell	8 studies	36% ± 21%	Explore
myeloid cell	8 studies	28% ± 11%	Explore
basal cell	7 studies	30% ± 18%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	29% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	7 studies	18% ± 3%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	7 studies	29% ± 12%	Explore
goblet cell	7 studies	25% ± 7%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	40% ± 17%	Explore
hematopoietic precursor cell	6 studies	43% ± 27%	Explore
secretory cell	6 studies	22% ± 4%	Explore
classical monocyte	6 studies	31% ± 12%	Explore
epithelial cell of proximal tubule	6 studies	24% ± 6%	Explore
kidney loop of Henle epithelial cell	6 studies	48% ± 22%	Explore
renal alpha-intercalated cell	6 studies	62% ± 14%	Explore
memory B cell	6 studies	17% ± 2%	Explore
mucosal invariant T cell	6 studies	20% ± 4%	Explore
neuron	6 studies	34% ± 14%	Explore
cardiac muscle cell	6 studies	32% ± 8%	Explore
ionocyte	5 studies	50% ± 7%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	58% ± 10%	Explore
intestinal crypt stem cell	5 studies	38% ± 7%	Explore
transit amplifying cell	5 studies	51% ± 25%	Explore
pro-B cell	5 studies	42% ± 8%	Explore
erythrocyte	5 studies	41% ± 24%	Explore
T follicular helper cell	5 studies	20% ± 2%	Explore
oligodendrocyte precursor cell	5 studies	30% ± 7%	Explore
deuterosomal cell	4 studies	48% ± 9%	Explore
mononuclear phagocyte	4 studies	32% ± 22%	Explore
exhausted T cell	4 studies	47% ± 8%	Explore
enteroendocrine cell	4 studies	36% ± 10%	Explore
leukocyte	4 studies	38% ± 17%	Explore
IgG plasma cell	4 studies	31% ± 15%	Explore
erythroblast	4 studies	46% ± 24%	Explore
hematopoietic stem cell	4 studies	37% ± 5%	Explore
brush cell	4 studies	24% ± 8%	Explore
microglial cell	4 studies	25% ± 6%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	39% ± 5%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	30% ± 12%	Explore
hepatocyte	4 studies	45% ± 20%	Explore
luminal cell of prostate epithelium	4 studies	34% ± 8%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	29% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	28% ± 3%	Explore
respiratory goblet cell	3 studies	30% ± 18%	Explore
neural crest cell	3 studies	43% ± 11%	Explore
IgA plasma cell	3 studies	30% ± 16%	Explore
renal principal cell	3 studies	41% ± 16%	Explore
extravillous trophoblast	3 studies	54% ± 25%	Explore
placental villous trophoblast	3 studies	68% ± 25%	Explore
common myeloid progenitor	3 studies	36% ± 17%	Explore
lymphocyte	3 studies	39% ± 19%	Explore
immature B cell	3 studies	39% ± 25%	Explore
precursor B cell	3 studies	40% ± 15%	Explore
mucus secreting cell	3 studies	27% ± 5%	Explore
intraepithelial lymphocyte	3 studies	35% ± 18%	Explore
germinal center B cell	3 studies	24% ± 8%	Explore
intermediate monocyte	3 studies	37% ± 12%	Explore
GABAergic neuron	3 studies	21% ± 3%	Explore
glutamatergic neuron	3 studies	32% ± 6%	Explore
mast cell	3 studies	21% ± 6%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	47% ± 25%	Explore
club cell	3 studies	24% ± 6%	Explore
oligodendrocyte	3 studies	26% ± 7%	Explore
T-helper 1 cell	3 studies	23% ± 2%	Explore
T-helper 17 cell	3 studies	29% ± 6%	Explore
double negative thymocyte	3 studies	47% ± 24%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	36% ± 5%	Explore
innate lymphoid cell	3 studies	21% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	12 studies	25% ± 9%	Explore
lung	11 studies	24% ± 9%	Explore
intestine	9 studies	25% ± 11%	Explore
kidney	8 studies	29% ± 4%	Explore
liver	7 studies	31% ± 22%	Explore
brain	6 studies	25% ± 6%	Explore
lymph node	5 studies	22% ± 9%	Explore
bone marrow	4 studies	22% ± 4%	Explore
placenta	3 studies	47% ± 25%	Explore
prostate	3 studies	18% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
kidney	100%	14991.00	89 / 89	99%	216.18	893 / 901
intestine	100%	8845.45	964 / 966	99%	285.45	523 / 527
liver	100%	18724.89	226 / 226	99%	265.82	402 / 406
prostate	99%	8183.68	243 / 245	100%	280.72	501 / 502
esophagus	99%	8618.63	1434 / 1445	99%	163.18	182 / 183
stomach	100%	13990.90	358 / 359	99%	246.23	282 / 286
bladder	100%	4648.71	21 / 21	98%	230.00	493 / 504
pancreas	100%	8358.19	328 / 328	97%	120.56	173 / 178
brain	95%	5391.51	2516 / 2642	100%	201.40	705 / 705
lung	95%	3555.80	551 / 578	99%	200.64	1144 / 1155
skin	94%	5484.91	1695 / 1809	92%	111.73	432 / 472
breast	84%	3656.61	384 / 459	99%	300.41	1111 / 1118
uterus	75%	2179.58	128 / 170	100%	297.70	459 / 459
thymus	59%	1443.52	387 / 653	89%	102.07	539 / 605
ovary	34%	763.41	62 / 180	99%	206.88	426 / 430
lymph node	0%	0	0 / 0	100%	265.51	29 / 29
muscle	100%	42277.54	803 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	238.69	45 / 45
ureter	0%	0	0 / 0	100%	139.35	1 / 1
spleen	99%	4223.88	238 / 241	0%	0	0 / 0
heart	98%	22694.51	848 / 861	0%	0	0 / 0
blood vessel	85%	2815.32	1134 / 1335	0%	0	0 / 0
peripheral blood	80%	5263.99	740 / 929	0%	0	0 / 0
adipose	70%	1957.51	845 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	66%	55.86	53 / 80
adrenal gland	6%	127.45	16 / 258	31%	22.40	72 / 230
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0005975	Biological process	carbohydrate metabolic process
GO_0006739	Biological process	NADP metabolic process
GO_0006103	Biological process	2-oxoglutarate metabolic process
GO_0006097	Biological process	glyoxylate cycle
GO_0006102	Biological process	isocitrate metabolic process
GO_0006099	Biological process	tricarboxylic acid cycle
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0005777	Cellular component	peroxisome
GO_0005759	Cellular component	mitochondrial matrix
GO_0005739	Cellular component	mitochondrion
GO_0051287	Molecular function	NAD binding
GO_0004450	Molecular function	isocitrate dehydrogenase (NADP+) activity
GO_0000287	Molecular function	magnesium ion binding

IV. Literature review

[source]

Gene name	IDH2
Protein name	isocitrate dehydrogenase (NADP(+)) (EC 1.1.1.42) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase) Isocitrate dehydrogenase Isocitrate dehydrogenase [NADP], mitochondrial (IDH) (EC 1.1.1.42) (ICD-M) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase) Isocitrate dehydrogenase (NADP(+)) 2
Synonyms
Description	FUNCTION: Plays a role in intermediary metabolism and energy production . It may tightly associate or interact with the pyruvate dehydrogenase complex . .
Accessions	ENST00000560061.1 ENST00000540499.2 [P48735-2] P48735 ENST00000559482.5 A0A1P8A7C0 H0YLL5 ENST00000330062.8 [P48735-1] H0YL11

IDH2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review