FH report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006281Biological processDNA repair
GO_0006106Biological processfumarate metabolic process
GO_0006108Biological processmalate metabolic process
GO_0006099Biological processtricarboxylic acid cycle
GO_0048873Biological processhomeostasis of number of cells within a tissue
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_0005694Cellular componentchromosome
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0005759Cellular componentmitochondrial matrix
GO_0005737Cellular componentcytoplasm
GO_0005739Cellular componentmitochondrion
GO_0005634Cellular componentnucleus
GO_0004333Molecular functionfumarate hydratase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFH
Protein nameFumarate hydratase isoform 7
Fumarate hydratase isoform 4
Fumarate hydratase isoform 5
Fumarate hydratase
Fumarate hydratase isoform 6
Fumarate hydratase isoform 2
Fumarate hydratase, mitochondrial (Fumarase) (HsFH) (EC 4.2.1.2)
Fumarate hydratase, mitochondrial (EC 4.2.1.2)
Synonyms
DescriptionFUNCTION: Catalyzes the reversible stereospecific interconversion of fumarate to L-malate . Experiments in other species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). .; FUNCTION: [Isoform Mitochondrial]: Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. .; FUNCTION: [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate (By similarity). Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting non-homologous end-joining (NHEJ) . In response to DNA damage and phosphorylation by PRKDC, translocates to the nucleus and accumulates at DNA double-strand breaks (DSBs): acts by catalyzing formation of fumarate, an inhibitor of KDM2B histone demethylase activity, resulting in enhanced dimethylation of histone H3 'Lys-36' (H3K36me2) . .

FUNCTION: Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. .

FUNCTION: Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. .

AccessionsP07954
A0A0S2Z4C3
A0A0S2Z3W2
A0A0S2Z3X6
A0A804HKE6
A0A804HI24
A0A804HL52
ENST00000682162.1
A0A0S2Z3S9
A0A0S2Z408
ENST00000366560.4 [P07954-1]
ENST00000684483.1
Q7Z6G0
ENST00000683521.1
A0A0S2Z4H0