OGDH report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0021794Biological processthalamus development
GO_0006091Biological processgeneration of precursor metabolites and energy
GO_0006103Biological process2-oxoglutarate metabolic process
GO_0021766Biological processhippocampus development
GO_0006096Biological processglycolytic process
GO_0021860Biological processpyramidal neuron development
GO_0021695Biological processcerebellar cortex development
GO_0022028Biological processtangential migration from the subventricular zone to the olfactory bulb
GO_0021756Biological processstriatum development
GO_0061034Biological processolfactory bulb mitral cell layer development
GO_0006099Biological processtricarboxylic acid cycle
GO_0006104Biological processsuccinyl-CoA metabolic process
GO_0005739Cellular componentmitochondrion
GO_0031966Cellular componentmitochondrial membrane
GO_0045252Cellular componentoxoglutarate dehydrogenase complex
GO_0005759Cellular componentmitochondrial matrix
GO_0005634Cellular componentnucleus
GO_0030976Molecular functionthiamine pyrophosphate binding
GO_0004591Molecular functionoxoglutarate dehydrogenase (succinyl-transferring) activity
GO_0034602Molecular functionoxoglutarate dehydrogenase (NAD+) activity
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameOGDH
Protein nameOxoglutarate (Alpha-ketoglutarate) dehydrogenase
oxoglutarate dehydrogenase (succinyl-transferring) (EC 1.2.4.2) (Alpha-ketoglutarate dehydrogenase)
2-oxoglutarate dehydrogenase complex component E1 (EC 1.2.4.2) (2-oxoglutarate dehydrogenase, mitochondrial) (Alpha-ketoglutarate dehydrogenase) (Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase)
2-oxoglutarate dehydrogenase complex component E1 (E1o) (OGDC-E1) (OGDH-E1) (EC 1.2.4.2) (2-oxoglutarate dehydrogenase, mitochondrial) (Alpha-ketoglutarate dehydrogenase) (Alpha-KGDH-E1) (Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase)
Synonyms
DescriptionFUNCTION: 2-oxoglutarate dehydrogenase (E1o) component of the 2-oxoglutarate dehydrogenase complex (OGDHC) . Participates in the first step, rate limiting for the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) catalyzed by the whole OGDHC . Catalyzes the irreversible decarboxylation of 2-oxoglutarate (alpha-ketoglutarate) via the thiamine diphosphate (ThDP) cofactor and subsequent transfer of the decarboxylated acyl intermediate on an oxidized dihydrolipoyl group that is covalently amidated to the E2 enzyme (dihydrolipoyllysine-residue succinyltransferase or DLST) . Plays a key role in the Krebs (citric acid) cycle, which is a common pathway for oxidation of fuel molecules, including carbohydrates, fatty acids, and amino acids . Can catalyze the decarboxylation of 2-oxoadipate in vitro, but at a much lower rate than 2-oxoglutarate . Mainly active in the mitochondrion . A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A . .

AccessionsC9J4G7
A5XEI1
ENST00000444676.5
A2VCT2
A2VCT3
ENST00000449767.5 [Q02218-2]
E9PDF2
A5XEI0
ENST00000419661.5
ENST00000443864.6 [Q02218-3]
Q02218
ENST00000439616.6
ENST00000447398.6
ENST00000222673.6 [Q02218-1]
E9PFG7
E9PCR7