Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 12 studies | 25% ± 11% | |
| astrocyte | 12 studies | 31% ± 13% | |
| non-classical monocyte | 11 studies | 21% ± 7% | |
| regulatory T cell | 10 studies | 18% ± 2% | |
| macrophage | 9 studies | 29% ± 10% | |
| glutamatergic neuron | 7 studies | 39% ± 24% | |
| epithelial cell | 7 studies | 33% ± 14% | |
| type I pneumocyte | 7 studies | 22% ± 5% | |
| adipocyte | 6 studies | 26% ± 15% | |
| dendritic cell | 6 studies | 24% ± 6% | |
| type II pneumocyte | 6 studies | 21% ± 5% | |
| GABAergic neuron | 6 studies | 39% ± 20% | |
| oligodendrocyte | 6 studies | 24% ± 6% | |
| classical monocyte | 5 studies | 21% ± 5% | |
| microglial cell | 5 studies | 25% ± 5% | |
| myeloid cell | 5 studies | 24% ± 5% | |
| retina horizontal cell | 5 studies | 20% ± 4% | |
| cardiac muscle cell | 5 studies | 49% ± 12% | |
| ciliated cell | 5 studies | 24% ± 5% | |
| fibroblast | 5 studies | 19% ± 2% | |
| monocyte | 5 studies | 27% ± 7% | |
| T cell | 5 studies | 20% ± 2% | |
| retinal ganglion cell | 4 studies | 41% ± 19% | |
| retinal pigment epithelial cell | 4 studies | 30% ± 13% | |
| oligodendrocyte precursor cell | 4 studies | 26% ± 7% | |
| endothelial cell of lymphatic vessel | 4 studies | 20% ± 1% | |
| interneuron | 4 studies | 38% ± 19% | |
| neuron | 3 studies | 29% ± 11% | |
| plasma cell | 3 studies | 29% ± 9% | |
| mononuclear phagocyte | 3 studies | 19% ± 4% | |
| retinal rod cell | 3 studies | 21% ± 3% | |
| abnormal cell | 3 studies | 28% ± 3% | |
| ependymal cell | 3 studies | 32% ± 11% | |
| enterocyte | 3 studies | 19% ± 3% | |
| goblet cell | 3 studies | 32% ± 18% | |
| alveolar macrophage | 3 studies | 24% ± 7% | |
| lymphocyte | 3 studies | 26% ± 4% | |
| smooth muscle cell | 3 studies | 17% ± 3% | |
| kidney distal convoluted tubule epithelial cell | 3 studies | 23% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 11088.44 | 1445 / 1445 | 100% | 141.76 | 183 / 183 |
| intestine | 100% | 10843.38 | 966 / 966 | 100% | 113.90 | 527 / 527 |
| prostate | 100% | 6869.58 | 245 / 245 | 100% | 107.02 | 502 / 502 |
| stomach | 100% | 8094.62 | 359 / 359 | 100% | 112.61 | 286 / 286 |
| thymus | 100% | 11847.48 | 653 / 653 | 100% | 117.23 | 605 / 605 |
| skin | 100% | 9599.06 | 1808 / 1809 | 100% | 132.77 | 472 / 472 |
| kidney | 100% | 13168.03 | 89 / 89 | 100% | 171.46 | 900 / 901 |
| uterus | 100% | 7085.95 | 170 / 170 | 100% | 89.51 | 458 / 459 |
| lung | 100% | 8843.99 | 577 / 578 | 100% | 98.75 | 1154 / 1155 |
| breast | 100% | 6557.46 | 458 / 459 | 100% | 89.51 | 1113 / 1118 |
| bladder | 100% | 8259.48 | 21 / 21 | 99% | 90.92 | 500 / 504 |
| adrenal gland | 100% | 12824.07 | 258 / 258 | 99% | 109.15 | 228 / 230 |
| brain | 99% | 7375.86 | 2613 / 2642 | 100% | 113.00 | 705 / 705 |
| ovary | 99% | 4639.89 | 178 / 180 | 100% | 72.16 | 428 / 430 |
| liver | 97% | 4128.00 | 220 / 226 | 99% | 73.78 | 400 / 406 |
| pancreas | 90% | 2903.43 | 295 / 328 | 99% | 87.04 | 177 / 178 |
| adipose | 100% | 7642.33 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 137.21 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 96.26 | 29 / 29 |
| muscle | 100% | 38178.59 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 7629.94 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 107.05 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 47.51 | 1 / 1 |
| blood vessel | 100% | 8398.83 | 1333 / 1335 | 0% | 0 | 0 / 0 |
| heart | 99% | 30749.49 | 852 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 94% | 5810.74 | 873 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0021794 | Biological process | thalamus development |
| GO_0006091 | Biological process | generation of precursor metabolites and energy |
| GO_0006103 | Biological process | 2-oxoglutarate metabolic process |
| GO_0021766 | Biological process | hippocampus development |
| GO_0006096 | Biological process | glycolytic process |
| GO_0021860 | Biological process | pyramidal neuron development |
| GO_0021695 | Biological process | cerebellar cortex development |
| GO_0022028 | Biological process | tangential migration from the subventricular zone to the olfactory bulb |
| GO_0021756 | Biological process | striatum development |
| GO_0061034 | Biological process | olfactory bulb mitral cell layer development |
| GO_0006099 | Biological process | tricarboxylic acid cycle |
| GO_0006104 | Biological process | succinyl-CoA metabolic process |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0031966 | Cellular component | mitochondrial membrane |
| GO_0045252 | Cellular component | oxoglutarate dehydrogenase complex |
| GO_0005759 | Cellular component | mitochondrial matrix |
| GO_0005634 | Cellular component | nucleus |
| GO_0030976 | Molecular function | thiamine pyrophosphate binding |
| GO_0004591 | Molecular function | oxoglutarate dehydrogenase (succinyl-transferring) activity |
| GO_0034602 | Molecular function | oxoglutarate dehydrogenase (NAD+) activity |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | OGDH |
| Protein name | Oxoglutarate (Alpha-ketoglutarate) dehydrogenase oxoglutarate dehydrogenase (succinyl-transferring) (EC 1.2.4.2) (Alpha-ketoglutarate dehydrogenase) 2-oxoglutarate dehydrogenase complex component E1 (EC 1.2.4.2) (2-oxoglutarate dehydrogenase, mitochondrial) (Alpha-ketoglutarate dehydrogenase) (Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase) 2-oxoglutarate dehydrogenase complex component E1 (E1o) (OGDC-E1) (OGDH-E1) (EC 1.2.4.2) (2-oxoglutarate dehydrogenase, mitochondrial) (Alpha-ketoglutarate dehydrogenase) (Alpha-KGDH-E1) (Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase) |
| Synonyms | |
| Description | FUNCTION: 2-oxoglutarate dehydrogenase (E1o) component of the 2-oxoglutarate dehydrogenase complex (OGDHC) . Participates in the first step, rate limiting for the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) catalyzed by the whole OGDHC . Catalyzes the irreversible decarboxylation of 2-oxoglutarate (alpha-ketoglutarate) via the thiamine diphosphate (ThDP) cofactor and subsequent transfer of the decarboxylated acyl intermediate on an oxidized dihydrolipoyl group that is covalently amidated to the E2 enzyme (dihydrolipoyllysine-residue succinyltransferase or DLST) . Plays a key role in the Krebs (citric acid) cycle, which is a common pathway for oxidation of fuel molecules, including carbohydrates, fatty acids, and amino acids . Can catalyze the decarboxylation of 2-oxoadipate in vitro, but at a much lower rate than 2-oxoglutarate . Mainly active in the mitochondrion . A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A . . |
| Accessions | C9J4G7 A5XEI1 ENST00000444676.5 A2VCT2 A2VCT3 ENST00000449767.5 [Q02218-2] E9PDF2 A5XEI0 ENST00000419661.5 ENST00000443864.6 [Q02218-3] Q02218 ENST00000439616.6 ENST00000447398.6 ENST00000222673.6 [Q02218-1] E9PFG7 E9PCR7 |