SUCLG1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1901289Biological processsuccinyl-CoA catabolic process
GO_0006099Biological processtricarboxylic acid cycle
GO_0045244Cellular componentsuccinate-CoA ligase complex (GDP-forming)
GO_0005739Cellular componentmitochondrion
GO_0009361Cellular componentsuccinate-CoA ligase complex (ADP-forming)
GO_0005759Cellular componentmitochondrial matrix
GO_0004776Molecular functionsuccinate-CoA ligase (GDP-forming) activity
GO_0004775Molecular functionsuccinate-CoA ligase (ADP-forming) activity
GO_0005515Molecular functionprotein binding
GO_0000166Molecular functionnucleotide binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameSUCLG1
Protein nameSuccinate-CoA ligase GDP/ADP-forming subunit alpha
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)
Synonymstmp_locus_1
DescriptionFUNCTION: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. .

FUNCTION: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. .

FUNCTION: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. .

FUNCTION: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. .

AccessionsA0A494C0D1
B2R8A1
H7C233
P53597
ENST00000651342.1
A8K4W7
ENST00000393868.7
Q6IAL5
ENST00000442240.5