IDH3G | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	18 studies	21% ± 5%	Explore
classical monocyte	18 studies	25% ± 11%	Explore
non-classical monocyte	17 studies	27% ± 14%	Explore
pericyte	15 studies	20% ± 4%	Explore
conventional dendritic cell	13 studies	30% ± 17%	Explore
CD8-positive, alpha-beta T cell	12 studies	20% ± 4%	Explore
macrophage	12 studies	24% ± 9%	Explore
mast cell	10 studies	23% ± 7%	Explore
monocyte	10 studies	21% ± 6%	Explore
fibroblast	10 studies	23% ± 10%	Explore
smooth muscle cell	9 studies	21% ± 6%	Explore
regulatory T cell	9 studies	20% ± 3%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	21% ± 3%	Explore
CD16-positive, CD56-dim natural killer cell, human	8 studies	23% ± 4%	Explore
CD4-positive, alpha-beta T cell	8 studies	20% ± 5%	Explore
B cell	7 studies	20% ± 6%	Explore
dendritic cell	7 studies	33% ± 21%	Explore
plasmacytoid dendritic cell	7 studies	27% ± 7%	Explore
gamma-delta T cell	7 studies	22% ± 12%	Explore
mature NK T cell	6 studies	20% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	6 studies	19% ± 4%	Explore
epithelial cell of proximal tubule	6 studies	20% ± 3%	Explore
epithelial cell	6 studies	38% ± 17%	Explore
T cell	6 studies	19% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	22% ± 3%	Explore
myofibroblast cell	5 studies	22% ± 2%	Explore
endothelial cell	5 studies	29% ± 10%	Explore
ciliated cell	5 studies	30% ± 6%	Explore
hematopoietic precursor cell	4 studies	27% ± 10%	Explore
exhausted T cell	4 studies	24% ± 8%	Explore
retinal ganglion cell	4 studies	49% ± 27%	Explore
mucosal invariant T cell	4 studies	18% ± 1%	Explore
connective tissue cell	4 studies	24% ± 6%	Explore
enterocyte	4 studies	23% ± 2%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	22% ± 2%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	20% ± 5%	Explore
goblet cell	4 studies	23% ± 8%	Explore
basal cell	4 studies	30% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	23% ± 9%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	20% ± 3%	Explore
memory B cell	4 studies	16% ± 1%	Explore
plasma cell	3 studies	30% ± 15%	Explore
plasmablast	3 studies	57% ± 6%	Explore
mononuclear phagocyte	3 studies	33% ± 13%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	18% ± 2%	Explore
kidney loop of Henle epithelial cell	3 studies	24% ± 6%	Explore
neuron	3 studies	25% ± 13%	Explore
leukocyte	3 studies	20% ± 5%	Explore
myeloid cell	3 studies	30% ± 11%	Explore
abnormal cell	3 studies	19% ± 4%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	21% ± 0%	Explore
endothelial cell of vascular tree	3 studies	16% ± 2%	Explore
double negative thymocyte	3 studies	27% ± 13%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	10 studies	24% ± 8%	Explore
lung	6 studies	25% ± 5%	Explore
kidney	4 studies	18% ± 2%	Explore
intestine	4 studies	23% ± 11%	Explore
eye	3 studies	22% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	4320.31	258 / 258	100%	84.19	230 / 230
esophagus	100%	3129.70	1445 / 1445	100%	74.48	183 / 183
ovary	100%	3319.77	180 / 180	100%	78.19	430 / 430
pancreas	100%	1839.55	328 / 328	100%	64.15	178 / 178
skin	100%	3211.79	1809 / 1809	100%	82.85	472 / 472
stomach	100%	2774.42	359 / 359	100%	95.60	286 / 286
thymus	100%	3709.24	653 / 653	100%	75.87	605 / 605
uterus	100%	3491.35	170 / 170	100%	83.24	459 / 459
brain	100%	3773.67	2638 / 2642	100%	86.99	705 / 705
liver	100%	1814.92	226 / 226	100%	51.22	405 / 406
lung	100%	3139.41	578 / 578	100%	65.88	1152 / 1155
kidney	100%	4037.30	89 / 89	100%	68.32	898 / 901
intestine	100%	3602.22	966 / 966	100%	103.84	525 / 527
prostate	100%	3305.90	245 / 245	100%	82.08	500 / 502
bladder	100%	3066.57	21 / 21	99%	83.34	500 / 504
breast	100%	3600.63	459 / 459	99%	65.22	1109 / 1118
adipose	100%	3489.54	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	105.69	29 / 29
muscle	100%	3680.81	803 / 803	0%	0	0 / 0
spleen	100%	3715.39	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	73.61	45 / 45
ureter	0%	0	0 / 0	100%	50.79	1 / 1
blood vessel	100%	3808.05	1334 / 1335	0%	0	0 / 0
peripheral blood	99%	3085.40	922 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	99%	142.11	79 / 80
heart	99%	3494.36	850 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0005975	Biological process	carbohydrate metabolic process
GO_0006099	Biological process	tricarboxylic acid cycle
GO_0006102	Biological process	isocitrate metabolic process
GO_0005730	Cellular component	nucleolus
GO_0005759	Cellular component	mitochondrial matrix
GO_0005739	Cellular component	mitochondrion
GO_0051287	Molecular function	NAD binding
GO_0004449	Molecular function	isocitrate dehydrogenase (NAD+) activity
GO_0005524	Molecular function	ATP binding
GO_0005515	Molecular function	protein binding
GO_0000287	Molecular function	magnesium ion binding

IV. Literature review

[source]

Gene name	IDH3G
Protein name	Isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (Isocitric dehydrogenase subunit gamma) (NAD(+)-specific ICDH subunit gamma) Isocitrate dehydrogenase 3 gamma Isocitrate dehydrogenase [NAD] subunit, mitochondrial
Synonyms	hCG_2004980
Description	FUNCTION: Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. .
Accessions	H7C1W2 ENST00000444338.1 ENST00000444450.5 ENST00000370092.7 [P51553-2] ENST00000454076.5 ENST00000427365.6 Q2Q9C5 G5E9Q7 E9PF84 H0Y5Q7 ENST00000217901.10 [P51553-1] Q2Q9S4 E7EQB8 ENST00000370093.5 P51553

IDH3G report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review