IDH3B | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	17 studies	20% ± 5%	Explore
endothelial cell	10 studies	25% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	19% ± 3%	Explore
pericyte	9 studies	21% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	8 studies	21% ± 4%	Explore
fibroblast	8 studies	24% ± 7%	Explore
B cell	7 studies	22% ± 6%	Explore
CD8-positive, alpha-beta T cell	7 studies	21% ± 5%	Explore
smooth muscle cell	7 studies	22% ± 6%	Explore
gamma-delta T cell	7 studies	22% ± 14%	Explore
myofibroblast cell	6 studies	19% ± 4%	Explore
epithelial cell	6 studies	41% ± 15%	Explore
regulatory T cell	6 studies	17% ± 3%	Explore
non-classical monocyte	5 studies	28% ± 10%	Explore
CD4-positive, alpha-beta T cell	5 studies	23% ± 4%	Explore
classical monocyte	5 studies	29% ± 9%	Explore
conventional dendritic cell	5 studies	31% ± 15%	Explore
T cell	5 studies	19% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	20% ± 5%	Explore
mature NK T cell	4 studies	17% ± 3%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	18% ± 2%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	20% ± 4%	Explore
connective tissue cell	4 studies	25% ± 5%	Explore
epithelial cell of proximal tubule	4 studies	19% ± 1%	Explore
ciliated cell	4 studies	26% ± 5%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	18% ± 2%	Explore
basal cell	4 studies	29% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	21% ± 8%	Explore
plasmacytoid dendritic cell	4 studies	25% ± 7%	Explore
memory B cell	4 studies	16% ± 1%	Explore
naive B cell	3 studies	19% ± 3%	Explore
hematopoietic precursor cell	3 studies	32% ± 9%	Explore
retinal ganglion cell	3 studies	54% ± 25%	Explore
capillary endothelial cell	3 studies	18% ± 1%	Explore
precursor B cell	3 studies	20% ± 1%	Explore
erythroblast	3 studies	28% ± 16%	Explore
abnormal cell	3 studies	22% ± 8%	Explore
macrophage	3 studies	24% ± 6%	Explore
endothelial cell of vascular tree	3 studies	19% ± 3%	Explore
dendritic cell	3 studies	46% ± 15%	Explore
intestinal crypt stem cell	3 studies	23% ± 5%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	18% ± 2%	Explore
double negative thymocyte	3 studies	28% ± 16%	Explore
neuron	3 studies	27% ± 16%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	7 studies	23% ± 6%	Explore
lung	6 studies	23% ± 6%	Explore
kidney	3 studies	16% ± 1%	Explore
eye	3 studies	21% ± 6%	Explore
brain	3 studies	19% ± 2%	Explore
intestine	3 studies	25% ± 11%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	4604.24	1445 / 1445	100%	85.12	183 / 183
liver	100%	2630.13	226 / 226	100%	83.39	406 / 406
ovary	100%	4818.96	180 / 180	100%	128.80	430 / 430
prostate	100%	4235.82	245 / 245	100%	90.77	502 / 502
kidney	100%	4792.09	89 / 89	100%	112.45	900 / 901
thymus	100%	4720.72	653 / 653	100%	98.25	604 / 605
skin	100%	4537.76	1809 / 1809	100%	126.57	471 / 472
breast	100%	4602.89	459 / 459	100%	97.33	1115 / 1118
pancreas	100%	2174.41	327 / 328	100%	82.74	178 / 178
lung	100%	3686.38	578 / 578	100%	90.42	1151 / 1155
stomach	100%	3964.85	359 / 359	100%	106.06	285 / 286
brain	100%	4064.70	2632 / 2642	100%	122.61	705 / 705
uterus	100%	5009.80	170 / 170	100%	119.85	457 / 459
intestine	100%	5475.01	966 / 966	99%	119.33	524 / 527
adrenal gland	100%	4673.83	258 / 258	99%	88.70	228 / 230
bladder	100%	4382.86	21 / 21	99%	112.36	499 / 504
adipose	100%	4311.99	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	155.29	80 / 80
lymph node	0%	0	0 / 0	100%	137.11	29 / 29
muscle	100%	5865.45	803 / 803	0%	0	0 / 0
spleen	100%	4819.95	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	127.63	45 / 45
ureter	0%	0	0 / 0	100%	56.55	1 / 1
blood vessel	100%	3841.79	1334 / 1335	0%	0	0 / 0
heart	99%	6272.49	853 / 861	0%	0	0 / 0
peripheral blood	98%	3234.17	908 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006099	Biological process	tricarboxylic acid cycle
GO_0006102	Biological process	isocitrate metabolic process
GO_0005759	Cellular component	mitochondrial matrix
GO_0005739	Cellular component	mitochondrion
GO_0005634	Cellular component	nucleus
GO_0000287	Molecular function	magnesium ion binding
GO_0051287	Molecular function	NAD binding
GO_0004449	Molecular function	isocitrate dehydrogenase (NAD+) activity
GO_0009055	Molecular function	electron transfer activity

IV. Literature review

[source]

Gene name	IDH3B
Protein name	Isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta Isocitrate dehydrogenase [NAD] subunit, mitochondrial Alternative protein IDH3B Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (Isocitric dehydrogenase subunit beta) (NAD(+)-specific ICDH subunit beta)
Synonyms	hCG_39616
Description	FUNCTION: Plays a structural role to facilitate the assembly and ensure the full activity of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. . FUNCTION: Plays a structural role to facilitate the assembly and ensure the full activity of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. . FUNCTION: Plays a structural role to facilitate the assembly and ensure the full activity of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. .
Accessions	A0A0D9SET9 ENST00000613370.1 A0A087X2E5 ENST00000380851.9 [O43837-2] ENST00000474315.5 ENST00000477689.2 ENST00000466494.6 O43837 A0A0D9SG66 A0A087WZN1 L0R875 ENST00000380843.9 [O43837-1]

IDH3B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review