Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 21 studies | 29% ± 9% | |
epithelial cell | 9 studies | 42% ± 18% | |
adipocyte | 8 studies | 32% ± 14% | |
oligodendrocyte precursor cell | 8 studies | 28% ± 9% | |
club cell | 7 studies | 22% ± 5% | |
astrocyte | 7 studies | 26% ± 6% | |
enterocyte | 6 studies | 22% ± 3% | |
myeloid cell | 6 studies | 28% ± 16% | |
goblet cell | 5 studies | 24% ± 11% | |
hepatocyte | 5 studies | 46% ± 21% | |
alveolar macrophage | 4 studies | 20% ± 3% | |
respiratory goblet cell | 4 studies | 29% ± 9% | |
secretory cell | 4 studies | 29% ± 10% | |
classical monocyte | 4 studies | 23% ± 6% | |
conventional dendritic cell | 4 studies | 21% ± 3% | |
epithelial cell of proximal tubule | 4 studies | 21% ± 4% | |
endothelial cell | 4 studies | 24% ± 6% | |
basal cell | 4 studies | 33% ± 15% | |
retinal pigment epithelial cell | 4 studies | 31% ± 10% | |
fibroblast | 4 studies | 24% ± 5% | |
luminal cell of prostate epithelium | 4 studies | 20% ± 2% | |
GABAergic neuron | 4 studies | 26% ± 6% | |
glutamatergic neuron | 4 studies | 32% ± 8% | |
neuron | 4 studies | 27% ± 9% | |
microglial cell | 4 studies | 20% ± 2% | |
progenitor cell | 3 studies | 28% ± 9% | |
monocyte | 3 studies | 20% ± 5% | |
tissue-resident macrophage | 3 studies | 21% ± 3% | |
ciliated cell | 3 studies | 32% ± 6% | |
abnormal cell | 3 studies | 31% ± 15% | |
enteroendocrine cell | 3 studies | 26% ± 10% | |
transit amplifying cell | 3 studies | 22% ± 1% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 6721.53 | 244 / 245 | 100% | 309.04 | 502 / 502 |
liver | 100% | 11897.27 | 226 / 226 | 100% | 176.84 | 404 / 406 |
bladder | 100% | 8399.67 | 21 / 21 | 99% | 175.67 | 498 / 504 |
stomach | 99% | 4312.46 | 355 / 359 | 99% | 112.94 | 283 / 286 |
breast | 100% | 4987.73 | 457 / 459 | 97% | 89.81 | 1090 / 1118 |
ovary | 99% | 4212.07 | 178 / 180 | 98% | 72.05 | 422 / 430 |
intestine | 98% | 5382.55 | 942 / 966 | 98% | 126.97 | 519 / 527 |
pancreas | 96% | 2417.99 | 316 / 328 | 98% | 107.56 | 174 / 178 |
esophagus | 93% | 4269.80 | 1343 / 1445 | 99% | 96.63 | 182 / 183 |
uterus | 95% | 2074.31 | 161 / 170 | 95% | 83.34 | 438 / 459 |
skin | 98% | 3280.11 | 1765 / 1809 | 92% | 58.40 | 436 / 472 |
lung | 89% | 3868.95 | 516 / 578 | 99% | 122.82 | 1147 / 1155 |
thymus | 97% | 2211.37 | 633 / 653 | 91% | 51.96 | 549 / 605 |
brain | 85% | 1204.40 | 2252 / 2642 | 97% | 76.23 | 683 / 705 |
kidney | 96% | 3257.39 | 85 / 89 | 80% | 37.29 | 717 / 901 |
adrenal gland | 100% | 24422.43 | 258 / 258 | 74% | 62.75 | 170 / 230 |
spleen | 100% | 4341.73 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 78.01 | 1 / 1 |
adipose | 100% | 6900.93 | 1201 / 1204 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 98% | 67.40 | 44 / 45 |
blood vessel | 94% | 2149.24 | 1253 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 72% | 32.75 | 21 / 29 |
heart | 71% | 1197.41 | 609 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 64% | 1917.69 | 592 / 929 | 0% | 0 | 0 / 0 |
muscle | 48% | 611.89 | 388 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 39% | 12.77 | 31 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006739 | Biological process | NADP metabolic process |
GO_0006103 | Biological process | 2-oxoglutarate metabolic process |
GO_0060696 | Biological process | regulation of phospholipid catabolic process |
GO_0006097 | Biological process | glyoxylate cycle |
GO_0006099 | Biological process | tricarboxylic acid cycle |
GO_0048545 | Biological process | response to steroid hormone |
GO_0071071 | Biological process | regulation of phospholipid biosynthetic process |
GO_0006979 | Biological process | response to oxidative stress |
GO_0008585 | Biological process | female gonad development |
GO_0006102 | Biological process | isocitrate metabolic process |
GO_0006749 | Biological process | glutathione metabolic process |
GO_0005576 | Cellular component | extracellular region |
GO_0005739 | Cellular component | mitochondrion |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005777 | Cellular component | peroxisome |
GO_0034774 | Cellular component | secretory granule lumen |
GO_1904724 | Cellular component | tertiary granule lumen |
GO_1904813 | Cellular component | ficolin-1-rich granule lumen |
GO_0005829 | Cellular component | cytosol |
GO_0005782 | Cellular component | peroxisomal matrix |
GO_0005737 | Cellular component | cytoplasm |
GO_0042803 | Molecular function | protein homodimerization activity |
GO_0045296 | Molecular function | cadherin binding |
GO_0051287 | Molecular function | NAD binding |
GO_0042802 | Molecular function | identical protein binding |
GO_0004450 | Molecular function | isocitrate dehydrogenase (NADP+) activity |
GO_0000287 | Molecular function | magnesium ion binding |
GO_0050661 | Molecular function | NADP binding |
GO_0005515 | Molecular function | protein binding |
Gene name | IDH1 |
Protein name | isocitrate dehydrogenase (NADP(+)) (EC 1.1.1.42) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase) Isocitrate dehydrogenase (NADP(+)) 1 Isocitrate dehydrogenase [NADP] (EC 1.1.1.42) Isocitrate dehydrogenase [NADP] cytoplasmic (IDH) (IDH1) (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (IDPc) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase) NADP+-specific isocitrate dehydrogenase |
Synonyms | PICD |
Description | FUNCTION: Catalyzes the NADP(+)-dependent oxidative decarboxylation of isocitrate (D-threo-isocitrate) to 2-ketoglutarate (2-oxoglutarate), which is required by other enzymes such as the phytanoyl-CoA dioxygenase . Plays a critical role in the generation of NADPH, an important cofactor in many biosynthesis pathways . May act as a corneal epithelial crystallin and may be involved in maintaining corneal epithelial transparency (By similarity). . |
Accessions | O75874 ENST00000345146.7 Q6FI37 C9J4N6 ENST00000415913.5 C9JLU6 Q6FIA4 C9JJE5 ENST00000451391.5 ENST00000417583.5 ENST00000415282.5 Q0QER2 ENST00000446179.5 Q9H302 |