MDH1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	24 studies	27% ± 10%	Explore
CD8-positive, alpha-beta T cell	24 studies	31% ± 13%	Explore
CD4-positive, alpha-beta T cell	23 studies	30% ± 15%	Explore
B cell	22 studies	24% ± 7%	Explore
macrophage	22 studies	30% ± 13%	Explore
pericyte	22 studies	26% ± 8%	Explore
fibroblast	21 studies	30% ± 12%	Explore
smooth muscle cell	20 studies	36% ± 22%	Explore
regulatory T cell	20 studies	30% ± 10%	Explore
T cell	19 studies	28% ± 10%	Explore
conventional dendritic cell	16 studies	31% ± 14%	Explore
basal cell	16 studies	36% ± 20%	Explore
ciliated cell	16 studies	42% ± 17%	Explore
epithelial cell	16 studies	36% ± 20%	Explore
endothelial cell	14 studies	25% ± 8%	Explore
naive B cell	12 studies	21% ± 5%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	21% ± 5%	Explore
non-classical monocyte	12 studies	27% ± 11%	Explore
myofibroblast cell	12 studies	35% ± 15%	Explore
connective tissue cell	12 studies	32% ± 12%	Explore
gamma-delta T cell	12 studies	29% ± 16%	Explore
CD16-positive, CD56-dim natural killer cell, human	11 studies	25% ± 7%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	26% ± 6%	Explore
plasmacytoid dendritic cell	11 studies	28% ± 11%	Explore
memory B cell	11 studies	24% ± 7%	Explore
plasma cell	10 studies	34% ± 15%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	25% ± 6%	Explore
mature NK T cell	10 studies	24% ± 5%	Explore
mucosal invariant T cell	10 studies	22% ± 5%	Explore
plasmablast	9 studies	38% ± 24%	Explore
classical monocyte	9 studies	26% ± 10%	Explore
progenitor cell	9 studies	28% ± 7%	Explore
abnormal cell	9 studies	29% ± 9%	Explore
neuron	9 studies	39% ± 15%	Explore
glutamatergic neuron	9 studies	45% ± 23%	Explore
astrocyte	9 studies	29% ± 9%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	29% ± 11%	Explore
mesothelial cell	8 studies	38% ± 17%	Explore
myeloid cell	8 studies	29% ± 9%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	31% ± 13%	Explore
epithelial cell of proximal tubule	7 studies	59% ± 15%	Explore
enterocyte	7 studies	24% ± 6%	Explore
transit amplifying cell	7 studies	23% ± 4%	Explore
retinal rod cell	7 studies	32% ± 15%	Explore
dendritic cell	7 studies	38% ± 18%	Explore
adipocyte	7 studies	31% ± 18%	Explore
mast cell	7 studies	22% ± 5%	Explore
alveolar macrophage	6 studies	37% ± 11%	Explore
hematopoietic precursor cell	6 studies	36% ± 19%	Explore
club cell	6 studies	31% ± 11%	Explore
secretory cell	6 studies	41% ± 25%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	39% ± 19%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	28% ± 6%	Explore
kidney loop of Henle epithelial cell	6 studies	40% ± 12%	Explore
renal alpha-intercalated cell	6 studies	50% ± 12%	Explore
monocyte	6 studies	22% ± 4%	Explore
retinal ganglion cell	6 studies	75% ± 26%	Explore
retinal cone cell	6 studies	43% ± 19%	Explore
endothelial cell of lymphatic vessel	6 studies	27% ± 8%	Explore
cardiac muscle cell	6 studies	52% ± 11%	Explore
T follicular helper cell	6 studies	22% ± 2%	Explore
GABAergic neuron	6 studies	50% ± 16%	Explore
oligodendrocyte	6 studies	23% ± 6%	Explore
oligodendrocyte precursor cell	6 studies	32% ± 8%	Explore
ionocyte	5 studies	39% ± 9%	Explore
goblet cell	5 studies	29% ± 11%	Explore
pro-B cell	5 studies	37% ± 5%	Explore
amacrine cell	5 studies	51% ± 14%	Explore
microglial cell	5 studies	22% ± 8%	Explore
respiratory goblet cell	4 studies	31% ± 18%	Explore
leukocyte	4 studies	28% ± 10%	Explore
exhausted T cell	4 studies	36% ± 7%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	56% ± 9%	Explore
enteroendocrine cell	4 studies	34% ± 14%	Explore
intestinal crypt stem cell	4 studies	29% ± 11%	Explore
OFF-bipolar cell	4 studies	48% ± 30%	Explore
ON-bipolar cell	4 studies	53% ± 27%	Explore
erythroblast	4 studies	37% ± 15%	Explore
innate lymphoid cell	4 studies	21% ± 3%	Explore
precursor B cell	4 studies	36% ± 11%	Explore
type I pneumocyte	4 studies	31% ± 7%	Explore
retina horizontal cell	4 studies	53% ± 13%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	44% ± 7%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	37% ± 12%	Explore
hematopoietic stem cell	4 studies	26% ± 7%	Explore
interneuron	4 studies	48% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	23% ± 8%	Explore
deuterosomal cell	3 studies	22% ± 3%	Explore
duct epithelial cell	3 studies	23% ± 8%	Explore
precursor cell	3 studies	41% ± 9%	Explore
pancreatic A cell	3 studies	41% ± 13%	Explore
mononuclear phagocyte	3 studies	31% ± 13%	Explore
neural crest cell	3 studies	38% ± 7%	Explore
retinal bipolar neuron	3 studies	54% ± 20%	Explore
GABAergic amacrine cell	3 studies	36% ± 8%	Explore
glycinergic amacrine cell	3 studies	35% ± 8%	Explore
common myeloid progenitor	3 studies	30% ± 17%	Explore
brush cell	3 studies	32% ± 12%	Explore
immature B cell	3 studies	27% ± 5%	Explore
type II pneumocyte	3 studies	30% ± 9%	Explore
retinal pigment epithelial cell	3 studies	37% ± 20%	Explore
serous secreting cell	3 studies	26% ± 6%	Explore
intraepithelial lymphocyte	3 studies	33% ± 11%	Explore
Mueller cell	3 studies	33% ± 9%	Explore
rod bipolar cell	3 studies	56% ± 12%	Explore
muscle cell	3 studies	34% ± 13%	Explore
germinal center B cell	3 studies	33% ± 11%	Explore
intermediate monocyte	3 studies	30% ± 14%	Explore
granulocyte monocyte progenitor cell	3 studies	36% ± 23%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	39% ± 28%	Explore
group 3 innate lymphoid cell	3 studies	32% ± 15%	Explore
T-helper 17 cell	3 studies	39% ± 25%	Explore
T-helper 1 cell	3 studies	37% ± 16%	Explore
double negative thymocyte	3 studies	45% ± 22%	Explore
hepatocyte	3 studies	34% ± 17%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	14 studies	32% ± 16%	Explore
peripheral blood	14 studies	25% ± 7%	Explore
brain	12 studies	32% ± 19%	Explore
eye	10 studies	32% ± 16%	Explore
kidney	9 studies	34% ± 10%	Explore
intestine	8 studies	28% ± 11%	Explore
liver	6 studies	26% ± 16%	Explore
bone marrow	5 studies	19% ± 2%	Explore
heart	5 studies	27% ± 4%	Explore
lymph node	5 studies	27% ± 8%	Explore
uterus	4 studies	30% ± 14%	Explore
adrenal gland	3 studies	26% ± 1%	Explore
thymus	3 studies	50% ± 23%	Explore
breast	3 studies	18% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
stomach	100%	8818.72	358 / 359	100%	68.81	286 / 286
intestine	100%	8204.13	964 / 966	100%	79.47	526 / 527
kidney	100%	10976.06	89 / 89	100%	94.47	897 / 901
bladder	100%	6071.76	21 / 21	99%	89.19	501 / 504
esophagus	99%	7587.00	1434 / 1445	100%	62.05	183 / 183
breast	100%	8328.34	457 / 459	100%	94.78	1114 / 1118
adrenal gland	100%	12438.72	258 / 258	99%	130.08	228 / 230
skin	99%	6335.73	1784 / 1809	100%	135.88	472 / 472
brain	98%	17300.45	2587 / 2642	100%	109.99	705 / 705
thymus	98%	4936.66	638 / 653	100%	99.83	603 / 605
prostate	97%	4672.42	237 / 245	99%	81.41	499 / 502
uterus	96%	4465.14	163 / 170	100%	114.44	458 / 459
ovary	96%	3773.22	172 / 180	100%	69.25	430 / 430
liver	94%	5530.15	212 / 226	100%	96.39	404 / 406
lung	86%	3975.19	496 / 578	100%	93.36	1155 / 1155
pancreas	55%	1727.48	180 / 328	100%	66.57	178 / 178
lymph node	0%	0	0 / 0	100%	152.49	29 / 29
tonsil	0%	0	0 / 0	100%	111.15	45 / 45
ureter	0%	0	0 / 0	100%	32.80	1 / 1
muscle	100%	16692.35	800 / 803	0%	0	0 / 0
adipose	99%	9386.13	1197 / 1204	0%	0	0 / 0
spleen	99%	4583.66	238 / 241	0%	0	0 / 0
eye	0%	0	0 / 0	99%	96.86	79 / 80
blood vessel	99%	5731.84	1315 / 1335	0%	0	0 / 0
heart	97%	42053.30	836 / 861	0%	0	0 / 0
peripheral blood	32%	3757.62	298 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006739	Biological process	NADP metabolic process
GO_0006108	Biological process	malate metabolic process
GO_0006734	Biological process	NADH metabolic process
GO_0006094	Biological process	gluconeogenesis
GO_0006099	Biological process	tricarboxylic acid cycle
GO_0006107	Biological process	oxaloacetate metabolic process
GO_0005813	Cellular component	centrosome
GO_0005615	Cellular component	extracellular space
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0004470	Molecular function	malic enzyme activity
GO_0030060	Molecular function	L-malate dehydrogenase (NAD+) activity
GO_0047860	Molecular function	diiodophenylpyruvate reductase activity
GO_0005515	Molecular function	protein binding
GO_0047995	Molecular function	hydroxyphenylpyruvate reductase activity

IV. Literature review

[source]

Gene name	MDH1
Protein name	Malate dehydrogenase 1 Malate dehydrogenase (EC 1.1.1.37) Malate dehydrogenase, cytoplasmic (EC 1.1.1.37) (Aromatic alpha-keto acid reductase) (KAR) (EC 1.1.1.96) (Cytosolic malate dehydrogenase) Malate dehydrogenase, cytoplasmic (EC 1.1.1.96) (Aromatic alpha-keto acid reductase) (Cytosolic malate dehydrogenase)
Synonyms	MDHA
Description	FUNCTION: Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH . Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation . Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS) . .
Accessions	ENST00000421012.2 ENST00000544381.4 [P40925-1] A0A5K1VW95 ENST00000442225.5 C9JLV6 ENST00000409476.5 P40925 B9A041 B8ZZ51 ENST00000233114.13 [P40925-1] ENST00000409908.5 F8WFC2 ENST00000432309 ENST00000454035.5 ENST00000432309.6 [P40925-3] C9JF79 ENST00000436321.5 ENST00000539945.7 C9JRL4 C9IZI0

MDH1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review