ACO1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006101Biological processcitrate metabolic process
GO_0009791Biological processpost-embryonic development
GO_0010040Biological processresponse to iron(II) ion
GO_0006417Biological processregulation of translation
GO_0006879Biological processintracellular iron ion homeostasis
GO_0050892Biological processintestinal absorption
GO_0006099Biological processtricarboxylic acid cycle
GO_0005739Cellular componentmitochondrion
GO_0070062Cellular componentextracellular exosome
GO_0005794Cellular componentGolgi apparatus
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0003994Molecular functionaconitate hydratase activity
GO_0046872Molecular functionmetal ion binding
GO_0003723Molecular functionRNA binding
GO_0030350Molecular functioniron-responsive element binding
GO_0051538Molecular function3 iron, 4 sulfur cluster binding
GO_0005515Molecular functionprotein binding
GO_0051539Molecular function4 iron, 4 sulfur cluster binding

IV. Literature review

[source]
Gene nameACO1
Protein nameCytoplasmic aconitate hydratase (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) (Ferritin repressor protein) (Iron regulatory protein 1) (IRP1) (Iron-responsive element-binding protein 1) (IRE-BP 1)
SynonymsIREB1
DescriptionFUNCTION: Bifunctional iron sensor that switches between 2 activities depending on iron availability . Iron deprivation, promotes its mRNA binding activity through which it regulates the expression of genes involved in iron uptake, sequestration and utilization . Binds to iron-responsive elements (IRES) in the untranslated region of target mRNAs preventing for instance the translation of ferritin and aminolevulinic acid synthase and stabilizing the transferrin receptor mRNA . .; FUNCTION: Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate. .

AccessionsP21399
ENST00000541043.5
ENST00000309951.8
ENST00000379923.5