I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| astrocyte | 5 studies | 36% ± 17% | |
| Mueller cell | 3 studies | 29% ± 9% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| astrocyte | 5 studies | 36% ± 17% | |
| Mueller cell | 3 studies | 29% ± 9% |
Insufficient scRNA-seq data for expression of NDP at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 100% | 1287.97 | 2635 / 2642 | 99% | 57.92 | 698 / 705 |
| ovary | 98% | 1323.13 | 176 / 180 | 57% | 10.47 | 244 / 430 |
| uterus | 89% | 611.68 | 152 / 170 | 15% | 2.20 | 70 / 459 |
| prostate | 56% | 204.47 | 136 / 245 | 42% | 3.05 | 211 / 502 |
| breast | 35% | 114.41 | 161 / 459 | 36% | 14.35 | 402 / 1118 |
| lymph node | 0% | 0 | 0 / 0 | 21% | 1.89 | 6 / 29 |
| pancreas | 0% | 0 | 0 / 328 | 19% | 0.99 | 34 / 178 |
| adrenal gland | 0% | 0.81 | 1 / 258 | 15% | 2.01 | 35 / 230 |
| bladder | 5% | 10.10 | 1 / 21 | 8% | 0.60 | 40 / 504 |
| skin | 1% | 1.01 | 11 / 1809 | 11% | 1.79 | 50 / 472 |
| intestine | 0% | 0.14 | 1 / 966 | 9% | 0.85 | 50 / 527 |
| lung | 0% | 0 | 0 / 578 | 8% | 1.23 | 91 / 1155 |
| esophagus | 0% | 0.21 | 2 / 1445 | 8% | 0.62 | 14 / 183 |
| stomach | 2% | 3.60 | 7 / 359 | 6% | 0.48 | 16 / 286 |
| thymus | 2% | 5.21 | 12 / 653 | 5% | 0.43 | 29 / 605 |
| tonsil | 0% | 0 | 0 / 0 | 4% | 0.24 | 2 / 45 |
| eye | 0% | 0 | 0 / 0 | 4% | 0.45 | 3 / 80 |
| blood vessel | 2% | 4.64 | 30 / 1335 | 0% | 0 | 0 / 0 |
| kidney | 0% | 0 | 0 / 89 | 2% | 0.29 | 20 / 901 |
| liver | 0% | 0 | 0 / 226 | 1% | 0.15 | 4 / 406 |
| adipose | 1% | 0.93 | 7 / 1204 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| heart | 0% | 0 | 0 / 861 | 0% | 0 | 0 / 0 |
| muscle | 0% | 0 | 0 / 803 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0006366 | Biological process | transcription by RNA polymerase II |
| GO_0007601 | Biological process | visual perception |
| GO_0016567 | Biological process | protein ubiquitination |
| GO_0001525 | Biological process | angiogenesis |
| GO_0060856 | Biological process | establishment of blood-brain barrier |
| GO_0007224 | Biological process | smoothened signaling pathway |
| GO_0035640 | Biological process | exploration behavior |
| GO_0001974 | Biological process | blood vessel remodeling |
| GO_0006954 | Biological process | inflammatory response |
| GO_0000278 | Biological process | mitotic cell cycle |
| GO_0061518 | Biological process | microglial cell proliferation |
| GO_1990963 | Biological process | establishment of blood-retinal barrier |
| GO_0006622 | Biological process | protein targeting to lysosome |
| GO_0045446 | Biological process | endothelial cell differentiation |
| GO_0070086 | Biological process | ubiquitin-dependent endocytosis |
| GO_0046697 | Biological process | decidualization |
| GO_0006544 | Biological process | glycine metabolic process |
| GO_0003406 | Biological process | retinal pigment epithelium development |
| GO_0060221 | Biological process | retinal rod cell differentiation |
| GO_0061304 | Biological process | retinal blood vessel morphogenesis |
| GO_0048678 | Biological process | response to axon injury |
| GO_0097601 | Biological process | retina blood vessel maintenance |
| GO_0110135 | Biological process | Norrin signaling pathway |
| GO_0060070 | Biological process | canonical Wnt signaling pathway |
| GO_0007033 | Biological process | vacuole organization |
| GO_0021554 | Biological process | optic nerve development |
| GO_0051402 | Biological process | neuron apoptotic process |
| GO_0060996 | Biological process | dendritic spine development |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0014004 | Biological process | microglia differentiation |
| GO_1904390 | Biological process | cone retinal bipolar cell differentiation |
| GO_0006099 | Biological process | tricarboxylic acid cycle |
| GO_0002088 | Biological process | lens development in camera-type eye |
| GO_0051897 | Biological process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO_0035426 | Biological process | extracellular matrix-cell signaling |
| GO_0031290 | Biological process | retinal ganglion cell axon guidance |
| GO_0001508 | Biological process | action potential |
| GO_0007179 | Biological process | transforming growth factor beta receptor signaling pathway |
| GO_0007399 | Biological process | nervous system development |
| GO_0006749 | Biological process | glutathione metabolic process |
| GO_0000320 | Biological process | re-entry into mitotic cell cycle |
| GO_0010842 | Biological process | retina layer formation |
| GO_0071456 | Biological process | cellular response to hypoxia |
| GO_0005615 | Cellular component | extracellular space |
| GO_0062023 | Cellular component | collagen-containing extracellular matrix |
| GO_0009986 | Cellular component | cell surface |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0005109 | Molecular function | frizzled binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0005125 | Molecular function | cytokine activity |
| Gene name | NDP |
| Protein name | Norrin (Norrie disease protein) (X-linked exudative vitreoretinopathy 2 protein) |
| Synonyms | EVR2 |
| Description | FUNCTION: Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction. |
| Accessions | ENST00000642620.1 ENST00000647044.1 Q00604 |
