EGR1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0044849Biological processestrous cycle
GO_0032722Biological processpositive regulation of chemokine production
GO_0071506Biological processcellular response to mycophenolic acid
GO_1901875Biological processpositive regulation of post-translational protein modification
GO_0072303Biological processpositive regulation of glomerular metanephric mesangial cell proliferation
GO_0002931Biological processresponse to ischemia
GO_0046886Biological processpositive regulation of hormone biosynthetic process
GO_0033233Biological processregulation of protein sumoylation
GO_0009749Biological processresponse to glucose
GO_0045475Biological processlocomotor rhythm
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_2000182Biological processregulation of progesterone biosynthetic process
GO_0071504Biological processcellular response to heparin
GO_0010628Biological processpositive regulation of gene expression
GO_0032868Biological processresponse to insulin
GO_0070498Biological processinterleukin-1-mediated signaling pathway
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0072110Biological processglomerular mesangial cell proliferation
GO_0032922Biological processcircadian regulation of gene expression
GO_0043523Biological processregulation of neuron apoptotic process
GO_0071480Biological processcellular response to gamma radiation
GO_0030509Biological processBMP signaling pathway
GO_0032731Biological processpositive regulation of interleukin-1 beta production
GO_0030217Biological processT cell differentiation
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0001666Biological processresponse to hypoxia
GO_1902895Biological processpositive regulation of miRNA transcription
GO_0060086Biological processcircadian temperature homeostasis
GO_0035914Biological processskeletal muscle cell differentiation
GO_0098759Biological processcellular response to interleukin-8
GO_0044029Biological processpositive regulation of gene expression via chromosomal CpG island demethylation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_1990841Molecular functionpromoter-specific chromatin binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_0044729Molecular functionhemi-methylated DNA-binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0010385Molecular functiondouble-stranded methylated DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0035035Molecular functionhistone acetyltransferase binding
GO_0008270Molecular functionzinc ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEGR1
Protein nameEarly growth response protein
Early growth response protein 1 (EGR-1) (AT225) (Nerve growth factor-induced protein A) (NGFI-A) (Transcription factor ETR103) (Transcription factor Zif268) (Zinc finger protein 225) (Zinc finger protein Krox-24)
SynonymshCG_18777
ZNF225
KROX24
DescriptionFUNCTION: Transcriptional regulator . Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status . Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity). Regulates the amplitude of the expression rhythms of clock genes: BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription. Regulates the rhythmic expression of core-clock gene BMAL1 in the suprachiasmatic nucleus (SCN) (By similarity). .

FUNCTION: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. .

AccessionsQ546S1
ENST00000239938.5
P18146