Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 21 studies | 60% ± 23% | |
endothelial cell | 16 studies | 27% ± 14% | |
oligodendrocyte precursor cell | 15 studies | 44% ± 17% | |
oligodendrocyte | 14 studies | 38% ± 12% | |
glutamatergic neuron | 12 studies | 52% ± 24% | |
GABAergic neuron | 11 studies | 56% ± 26% | |
microglial cell | 11 studies | 27% ± 11% | |
macrophage | 9 studies | 32% ± 12% | |
amacrine cell | 8 studies | 41% ± 11% | |
type I pneumocyte | 7 studies | 24% ± 9% | |
neuron | 7 studies | 43% ± 16% | |
interneuron | 7 studies | 64% ± 19% | |
pericyte | 7 studies | 26% ± 15% | |
retinal ganglion cell | 7 studies | 66% ± 15% | |
retinal cone cell | 7 studies | 24% ± 7% | |
fibroblast | 7 studies | 20% ± 3% | |
epithelial cell | 6 studies | 34% ± 7% | |
retina horizontal cell | 6 studies | 38% ± 14% | |
adipocyte | 6 studies | 22% ± 4% | |
endothelial cell of lymphatic vessel | 5 studies | 24% ± 4% | |
non-classical monocyte | 5 studies | 19% ± 6% | |
retinal bipolar neuron | 5 studies | 55% ± 14% | |
myeloid cell | 5 studies | 23% ± 8% | |
monocyte | 5 studies | 23% ± 7% | |
smooth muscle cell | 4 studies | 22% ± 4% | |
granule cell | 4 studies | 35% ± 11% | |
retinal pigment epithelial cell | 4 studies | 38% ± 4% | |
cardiac muscle cell | 4 studies | 21% ± 1% | |
dendritic cell | 4 studies | 22% ± 4% | |
lymphocyte | 4 studies | 19% ± 3% | |
OFF-bipolar cell | 4 studies | 44% ± 5% | |
ON-bipolar cell | 4 studies | 59% ± 8% | |
retinal rod cell | 4 studies | 17% ± 1% | |
GABAergic interneuron | 3 studies | 63% ± 4% | |
progenitor cell | 3 studies | 34% ± 7% | |
GABAergic amacrine cell | 3 studies | 55% ± 7% | |
glycinergic amacrine cell | 3 studies | 41% ± 8% | |
rod bipolar cell | 3 studies | 83% ± 5% | |
basal cell | 3 studies | 26% ± 13% | |
neural progenitor cell | 3 studies | 52% ± 26% | |
ependymal cell | 3 studies | 65% ± 17% | |
enteroendocrine cell | 3 studies | 18% ± 2% | |
alveolar macrophage | 3 studies | 27% ± 8% | |
mast cell | 3 studies | 19% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 9646.57 | 2641 / 2642 | 100% | 51.17 | 704 / 705 |
esophagus | 100% | 2481.01 | 1439 / 1445 | 99% | 13.36 | 182 / 183 |
breast | 100% | 1995.94 | 457 / 459 | 96% | 12.84 | 1072 / 1118 |
adrenal gland | 99% | 1900.03 | 255 / 258 | 95% | 11.51 | 218 / 230 |
lung | 97% | 1973.85 | 558 / 578 | 95% | 8.01 | 1097 / 1155 |
prostate | 98% | 1659.29 | 241 / 245 | 92% | 9.03 | 461 / 502 |
thymus | 99% | 1627.03 | 648 / 653 | 90% | 7.23 | 547 / 605 |
uterus | 99% | 1961.94 | 169 / 170 | 90% | 7.69 | 414 / 459 |
skin | 99% | 2480.42 | 1797 / 1809 | 89% | 10.21 | 418 / 472 |
intestine | 100% | 2660.87 | 965 / 966 | 87% | 6.81 | 458 / 527 |
kidney | 97% | 1260.03 | 86 / 89 | 90% | 9.76 | 807 / 901 |
bladder | 100% | 1907.67 | 21 / 21 | 82% | 5.84 | 411 / 504 |
pancreas | 86% | 992.97 | 281 / 328 | 94% | 8.18 | 168 / 178 |
stomach | 87% | 1328.78 | 311 / 359 | 91% | 8.20 | 259 / 286 |
ovary | 96% | 1336.05 | 172 / 180 | 71% | 3.93 | 304 / 430 |
liver | 89% | 1002.20 | 201 / 226 | 65% | 3.95 | 263 / 406 |
spleen | 100% | 2264.63 | 241 / 241 | 0% | 0 | 0 / 0 |
adipose | 100% | 2345.74 | 1203 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 99% | 2365.69 | 1328 / 1335 | 0% | 0 | 0 / 0 |
muscle | 99% | 2517.82 | 798 / 803 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 93% | 10.38 | 42 / 45 |
heart | 86% | 1391.09 | 740 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 76% | 5.81 | 22 / 29 |
eye | 0% | 0 | 0 / 0 | 57% | 4.02 | 46 / 80 |
peripheral blood | 56% | 1059.73 | 522 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0008285 | Biological process | negative regulation of cell population proliferation |
GO_0032886 | Biological process | regulation of microtubule-based process |
GO_0001708 | Biological process | cell fate specification |
GO_1902807 | Biological process | negative regulation of cell cycle G1/S phase transition |
GO_0060632 | Biological process | regulation of microtubule-based movement |
GO_0006974 | Biological process | DNA damage response |
GO_0051988 | Biological process | regulation of attachment of spindle microtubules to kinetochore |
GO_0003203 | Biological process | endocardial cushion morphogenesis |
GO_0000281 | Biological process | mitotic cytokinesis |
GO_0007155 | Biological process | cell adhesion |
GO_0090090 | Biological process | negative regulation of canonical Wnt signaling pathway |
GO_0007026 | Biological process | negative regulation of microtubule depolymerization |
GO_0065003 | Biological process | protein-containing complex assembly |
GO_0045732 | Biological process | positive regulation of protein catabolic process |
GO_0008286 | Biological process | insulin receptor signaling pathway |
GO_1904781 | Biological process | positive regulation of protein localization to centrosome |
GO_0003170 | Biological process | heart valve development |
GO_0030335 | Biological process | positive regulation of cell migration |
GO_0070830 | Biological process | bicellular tight junction assembly |
GO_0120162 | Biological process | positive regulation of cold-induced thermogenesis |
GO_2000134 | Biological process | negative regulation of G1/S transition of mitotic cell cycle |
GO_0031274 | Biological process | positive regulation of pseudopodium assembly |
GO_0016055 | Biological process | Wnt signaling pathway |
GO_0007399 | Biological process | nervous system development |
GO_0007094 | Biological process | mitotic spindle assembly checkpoint signaling |
GO_0045736 | Biological process | negative regulation of cyclin-dependent protein serine/threonine kinase activity |
GO_0043065 | Biological process | positive regulation of apoptotic process |
GO_0016477 | Biological process | cell migration |
GO_0043161 | Biological process | proteasome-mediated ubiquitin-dependent protein catabolic process |
GO_0007389 | Biological process | pattern specification process |
GO_0032587 | Cellular component | ruffle membrane |
GO_0005886 | Cellular component | plasma membrane |
GO_0005874 | Cellular component | microtubule |
GO_0048471 | Cellular component | perinuclear region of cytoplasm |
GO_0005813 | Cellular component | centrosome |
GO_0000776 | Cellular component | kinetochore |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0016342 | Cellular component | catenin complex |
GO_0030877 | Cellular component | beta-catenin destruction complex |
GO_0005829 | Cellular component | cytosol |
GO_0005912 | Cellular component | adherens junction |
GO_0005881 | Cellular component | cytoplasmic microtubule |
GO_0016328 | Cellular component | lateral plasma membrane |
GO_0005737 | Cellular component | cytoplasm |
GO_0005923 | Cellular component | bicellular tight junction |
GO_1990909 | Cellular component | Wnt signalosome |
GO_0030027 | Cellular component | lamellipodium |
GO_0005634 | Cellular component | nucleus |
GO_0051010 | Molecular function | microtubule plus-end binding |
GO_0019887 | Molecular function | protein kinase regulator activity |
GO_0045296 | Molecular function | cadherin binding |
GO_0019901 | Molecular function | protein kinase binding |
GO_0031625 | Molecular function | ubiquitin protein ligase binding |
GO_0008013 | Molecular function | beta-catenin binding |
GO_0008017 | Molecular function | microtubule binding |
GO_0045295 | Molecular function | gamma-catenin binding |
GO_0070840 | Molecular function | dynein complex binding |
GO_0005515 | Molecular function | protein binding |
Gene name | APC |
Protein name | Adenomatous polyposis coli protein Adenomatous polyposis coli Truncated adenomatous polyposis coli Adenomatous polyposisi coli APC variant protein Adenomatosis polyposis coli Adenomatous Polyposis Coli APC regulator of WNT signaling pathway APC protein Truncated adenomatosis polyposis coli tumor suppressor Adenomatous polyposis coli protein isoform t (HCG2031476, isoform CRA_d) Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) Adenomatous polyposis coli protein isoform b Adenomatosis polyposis coli tumor suppressor WNT signaling pathway regulator |
Synonyms | DP2.5 hCG_2031476 protein variant |
Description | FUNCTION: Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton . Plays a role in mediating the organization of F-actin into ordered bundles . Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. . |
Accessions | A1YR11 A5JUM8 A0A1Y6IPP8 A0A087WYF3 Q16098 A1YIX6 ENST00000509732.6 [P25054-1] Q9HAW6 A5HB97 A0A1Y6IM94 D6RFL6 A0A1Y6IM53 E9PFT7 ENST00000508624.5 Q16097 A5JUM9 A1YIQ7 A5JUM6 Q5EBR9 ENST00000508376.6 [P25054-1] A5JUM7 ENST00000507379.5 Q4LE70 Q7Z2Q8 A0A1Y6IRU6 A0A087X2F3 P25054 Q5EBR8 Q9P119 A0A1Y6IM71 ENST00000505350.2 A0A1Y6IQK5 A0A386AVV0 E7EMH9 A0A1Y6IQI2 ENST00000512211.7 [P25054-1] A0A2Q2SV78 A0A224AV41 R4GMU6 A0A224ANK2 ENST00000509732.5 Q5EEK4 ENST00000502371.3 ENST00000512211.6 ENST00000257430.9 [P25054-1] A5HB94 A0A1Y6IM95 ENST00000507379.6 [P25054-3] ENST00000504915.3 A5HB95 A5HB96 Q9UM98 |