APC report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008285Biological processnegative regulation of cell population proliferation
GO_0032886Biological processregulation of microtubule-based process
GO_0001708Biological processcell fate specification
GO_1902807Biological processnegative regulation of cell cycle G1/S phase transition
GO_0060632Biological processregulation of microtubule-based movement
GO_0006974Biological processDNA damage response
GO_0051988Biological processregulation of attachment of spindle microtubules to kinetochore
GO_0003203Biological processendocardial cushion morphogenesis
GO_0000281Biological processmitotic cytokinesis
GO_0007155Biological processcell adhesion
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0007026Biological processnegative regulation of microtubule depolymerization
GO_0065003Biological processprotein-containing complex assembly
GO_0045732Biological processpositive regulation of protein catabolic process
GO_0008286Biological processinsulin receptor signaling pathway
GO_1904781Biological processpositive regulation of protein localization to centrosome
GO_0003170Biological processheart valve development
GO_0030335Biological processpositive regulation of cell migration
GO_0070830Biological processbicellular tight junction assembly
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_2000134Biological processnegative regulation of G1/S transition of mitotic cell cycle
GO_0031274Biological processpositive regulation of pseudopodium assembly
GO_0016055Biological processWnt signaling pathway
GO_0007399Biological processnervous system development
GO_0007094Biological processmitotic spindle assembly checkpoint signaling
GO_0045736Biological processnegative regulation of cyclin-dependent protein serine/threonine kinase activity
GO_0043065Biological processpositive regulation of apoptotic process
GO_0016477Biological processcell migration
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0007389Biological processpattern specification process
GO_0032587Cellular componentruffle membrane
GO_0005886Cellular componentplasma membrane
GO_0005874Cellular componentmicrotubule
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005813Cellular componentcentrosome
GO_0000776Cellular componentkinetochore
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0016342Cellular componentcatenin complex
GO_0030877Cellular componentbeta-catenin destruction complex
GO_0005829Cellular componentcytosol
GO_0005912Cellular componentadherens junction
GO_0005881Cellular componentcytoplasmic microtubule
GO_0016328Cellular componentlateral plasma membrane
GO_0005737Cellular componentcytoplasm
GO_0005923Cellular componentbicellular tight junction
GO_1990909Cellular componentWnt signalosome
GO_0030027Cellular componentlamellipodium
GO_0005634Cellular componentnucleus
GO_0051010Molecular functionmicrotubule plus-end binding
GO_0019887Molecular functionprotein kinase regulator activity
GO_0045296Molecular functioncadherin binding
GO_0019901Molecular functionprotein kinase binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0008013Molecular functionbeta-catenin binding
GO_0008017Molecular functionmicrotubule binding
GO_0045295Molecular functiongamma-catenin binding
GO_0070840Molecular functiondynein complex binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAPC
Protein nameAdenomatous polyposis coli protein
Adenomatous polyposis coli
Truncated adenomatous polyposis coli
Adenomatous polyposisi coli
APC variant protein
Adenomatosis polyposis coli
Adenomatous Polyposis Coli
APC regulator of WNT signaling pathway
APC protein
Truncated adenomatosis polyposis coli tumor suppressor
Adenomatous polyposis coli protein isoform t (HCG2031476, isoform CRA_d)
Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5)
Adenomatous polyposis coli protein isoform b
Adenomatosis polyposis coli tumor suppressor
WNT signaling pathway regulator
SynonymsDP2.5
hCG_2031476
protein
variant
DescriptionFUNCTION: Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton . Plays a role in mediating the organization of F-actin into ordered bundles . Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. .

AccessionsA1YR11
A5JUM8
A0A1Y6IPP8
A0A087WYF3
Q16098
A1YIX6
ENST00000509732.6 [P25054-1]
Q9HAW6
A5HB97
A0A1Y6IM94
D6RFL6
A0A1Y6IM53
E9PFT7
ENST00000508624.5
Q16097
A5JUM9
A1YIQ7
A5JUM6
Q5EBR9
ENST00000508376.6 [P25054-1]
A5JUM7
ENST00000507379.5
Q4LE70
Q7Z2Q8
A0A1Y6IRU6
A0A087X2F3
P25054
Q5EBR8
Q9P119
A0A1Y6IM71
ENST00000505350.2
A0A1Y6IQK5
A0A386AVV0
E7EMH9
A0A1Y6IQI2
ENST00000512211.7 [P25054-1]
A0A2Q2SV78
A0A224AV41
R4GMU6
A0A224ANK2
ENST00000509732.5
Q5EEK4
ENST00000502371.3
ENST00000512211.6
ENST00000257430.9 [P25054-1]
A5HB94
A0A1Y6IM95
ENST00000507379.6 [P25054-3]
ENST00000504915.3
A5HB95
A5HB96
Q9UM98