SHH report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SHH at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SHH at tissue level.

III. Associated gene sets

GO_0021794Biological processthalamus development
GO_0002052Biological processpositive regulation of neuroblast proliferation
GO_0010468Biological processregulation of gene expression
GO_0001658Biological processbranching involved in ureteric bud morphogenesis
GO_2000358Biological processpositive regulation of kidney smooth muscle cell differentiation
GO_0030324Biological processlung development
GO_0014858Biological processpositive regulation of skeletal muscle cell proliferation
GO_0060459Biological processleft lung development
GO_0042098Biological processT cell proliferation
GO_0014856Biological processskeletal muscle cell proliferation
GO_0001947Biological processheart looping
GO_0001656Biological processmetanephros development
GO_0060685Biological processregulation of prostatic bud formation
GO_0042733Biological processembryonic digit morphogenesis
GO_0030850Biological processprostate gland development
GO_0030878Biological processthyroid gland development
GO_0097152Biological processmesenchymal cell apoptotic process
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0033085Biological processnegative regulation of T cell differentiation in thymus
GO_0035115Biological processembryonic forelimb morphogenesis
GO_0007267Biological processcell-cell signaling
GO_0060783Biological processmesenchymal smoothened signaling pathway involved in prostate gland development
GO_0033092Biological processpositive regulation of immature T cell proliferation in thymus
GO_0045109Biological processintermediate filament organization
GO_0060021Biological processroof of mouth development
GO_0060447Biological processbud outgrowth involved in lung branching
GO_0060769Biological processpositive regulation of epithelial cell proliferation involved in prostate gland development
GO_0043066Biological processnegative regulation of apoptotic process
GO_0097264Biological processself proteolysis
GO_0060251Biological processregulation of glial cell proliferation
GO_0098528Biological processskeletal muscle fiber differentiation
GO_0007417Biological processcentral nervous system development
GO_1900180Biological processregulation of protein localization to nucleus
GO_0021513Biological processspinal cord dorsal/ventral patterning
GO_0060662Biological processsalivary gland cavitation
GO_0007398Biological processectoderm development
GO_2000357Biological processnegative regulation of kidney smooth muscle cell differentiation
GO_0071285Biological processcellular response to lithium ion
GO_0072089Biological processstem cell proliferation
GO_0042475Biological processodontogenesis of dentin-containing tooth
GO_0097190Biological processapoptotic signaling pathway
GO_0051781Biological processpositive regulation of cell division
GO_0046639Biological processnegative regulation of alpha-beta T cell differentiation
GO_0007224Biological processsmoothened signaling pathway
GO_0032435Biological processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0006897Biological processendocytosis
GO_0001755Biological processneural crest cell migration
GO_0010629Biological processnegative regulation of gene expression
GO_0030900Biological processforebrain development
GO_0016540Biological processprotein autoprocessing
GO_0010628Biological processpositive regulation of gene expression
GO_0048711Biological processpositive regulation of astrocyte differentiation
GO_0042307Biological processpositive regulation of protein import into nucleus
GO_0060439Biological processtrachea morphogenesis
GO_0060463Biological processlung lobe morphogenesis
GO_0033077Biological processT cell differentiation in thymus
GO_1905327Biological processtracheoesophageal septum formation
GO_0048706Biological processembryonic skeletal system development
GO_0042130Biological processnegative regulation of T cell proliferation
GO_0030326Biological processembryonic limb morphogenesis
GO_0072136Biological processmetanephric mesenchymal cell proliferation involved in metanephros development
GO_0006606Biological processprotein import into nucleus
GO_0060767Biological processepithelial cell proliferation involved in prostate gland development
GO_2000063Biological processpositive regulation of ureter smooth muscle cell differentiation
GO_0051155Biological processpositive regulation of striated muscle cell differentiation
GO_0060782Biological processregulation of mesenchymal cell proliferation involved in prostate gland development
GO_0030336Biological processnegative regulation of cell migration
GO_0043010Biological processcamera-type eye development
GO_0007442Biological processhindgut morphogenesis
GO_0045059Biological processpositive thymic T cell selection
GO_0045060Biological processnegative thymic T cell selection
GO_0003140Biological processdetermination of left/right asymmetry in lateral mesoderm
GO_0046632Biological processalpha-beta T cell differentiation
GO_0046638Biological processpositive regulation of alpha-beta T cell differentiation
GO_0060484Biological processlung-associated mesenchyme development
GO_0030177Biological processpositive regulation of Wnt signaling pathway
GO_0048617Biological processembryonic foregut morphogenesis
GO_0007418Biological processventral midline development
GO_0048745Biological processsmooth muscle tissue development
GO_0007405Biological processneuroblast proliferation
GO_0014003Biological processoligodendrocyte development
GO_0001708Biological processcell fate specification
GO_0008209Biological processandrogen metabolic process
GO_0060664Biological processepithelial cell proliferation involved in salivary gland morphogenesis
GO_0031016Biological processpancreas development
GO_0090162Biological processestablishment of epithelial cell polarity
GO_0060445Biological processbranching involved in salivary gland morphogenesis
GO_0060523Biological processprostate epithelial cord elongation
GO_0061053Biological processsomite development
GO_0009949Biological processpolarity specification of anterior/posterior axis
GO_0031069Biological processhair follicle morphogenesis
GO_0021978Biological processtelencephalon regionalization
GO_0048645Biological processanimal organ formation
GO_0001570Biological processvasculogenesis
GO_0007596Biological processblood coagulation
GO_0060174Biological processlimb bud formation
GO_0048643Biological processpositive regulation of skeletal muscle tissue development
GO_1904339Biological processnegative regulation of dopaminergic neuron differentiation
GO_0001569Biological processbranching involved in blood vessel morphogenesis
GO_0060516Biological processprimary prostatic bud elongation
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0021930Biological processcerebellar granule cell precursor proliferation
GO_0048538Biological processthymus development
GO_0048714Biological processpositive regulation of oligodendrocyte differentiation
GO_0045445Biological processmyoblast differentiation
GO_0060916Biological processmesenchymal cell proliferation involved in lung development
GO_0060840Biological processartery development
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0033089Biological processpositive regulation of T cell differentiation in thymus
GO_2000729Biological processpositive regulation of mesenchymal cell proliferation involved in ureter development
GO_2001054Biological processnegative regulation of mesenchymal cell apoptotic process
GO_0002320Biological processlymphoid progenitor cell differentiation
GO_0060458Biological processright lung development
GO_0048859Biological processformation of anatomical boundary
GO_0042127Biological processregulation of cell population proliferation
GO_0030901Biological processmidbrain development
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0042481Biological processregulation of odontogenesis
GO_0014706Biological processstriated muscle tissue development
GO_0060020Biological processBergmann glial cell differentiation
GO_0090370Biological processnegative regulation of cholesterol efflux
GO_0048754Biological processbranching morphogenesis of an epithelial tube
GO_0007507Biological processheart development
GO_0072205Biological processmetanephric collecting duct development
GO_0048663Biological processneuron fate commitment
GO_2000062Biological processnegative regulation of ureter smooth muscle cell differentiation
GO_0048839Biological processinner ear development
GO_0048864Biological processstem cell development
GO_0034244Biological processnegative regulation of transcription elongation by RNA polymerase II
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0061189Biological processpositive regulation of sclerotome development
GO_0021904Biological processdorsal/ventral neural tube patterning
GO_0071542Biological processdopaminergic neuron differentiation
GO_0035116Biological processembryonic hindlimb morphogenesis
GO_0060070Biological processcanonical Wnt signaling pathway
GO_0009953Biological processdorsal/ventral pattern formation
GO_0045880Biological processpositive regulation of smoothened signaling pathway
GO_0072091Biological processregulation of stem cell proliferation
GO_0009880Biological processembryonic pattern specification
GO_0030539Biological processmale genitalia development
GO_0048557Biological processembryonic digestive tract morphogenesis
GO_0048468Biological processcell development
GO_0036484Biological processtrunk neural crest cell migration
GO_0016539Biological processintein-mediated protein splicing
GO_0021940Biological processpositive regulation of cerebellar granule cell precursor proliferation
GO_0048709Biological processoligodendrocyte differentiation
GO_0060684Biological processepithelial-mesenchymal cell signaling
GO_0060428Biological processlung epithelium development
GO_0045596Biological processnegative regulation of cell differentiation
GO_0030902Biological processhindbrain development
GO_0030162Biological processregulation of proteolysis
GO_0002076Biological processosteoblast development
GO_0021522Biological processspinal cord motor neuron differentiation
GO_0043369Biological processCD4-positive or CD8-positive, alpha-beta T cell lineage commitment
GO_0007411Biological processaxon guidance
GO_0007389Biological processpattern specification process
GO_0045121Cellular componentmembrane raft
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0009986Cellular componentcell surface
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0005576Cellular componentextracellular region
GO_0005615Cellular componentextracellular space
GO_0005886Cellular componentplasma membrane
GO_0005794Cellular componentGolgi apparatus
GO_0000139Cellular componentGolgi membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0005829Cellular componentcytosol
GO_0008270Molecular functionzinc ion binding
GO_0005509Molecular functioncalcium ion binding
GO_0004175Molecular functionendopeptidase activity
GO_0005113Molecular functionpatched binding
GO_0140853Molecular functioncholesterol-protein transferase activity
GO_0008233Molecular functionpeptidase activity
GO_0016015Molecular functionmorphogen activity
GO_0005539Molecular functionglycosaminoglycan binding
GO_0005515Molecular functionprotein binding
GO_0043237Molecular functionlaminin-1 binding

IV. Literature review

[source]
Gene nameSHH
Protein nameSonic hedgehog protein (SHH) (EC 3.1.-.-) (HHG-1) (Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains) (ShhNC) [Cleaved into: Sonic hedgehog protein N-product (ShhN) (Shh N-terminal processed signaling domains) (ShhNp)]
Hedgehog protein
Sonic hedgehog signaling molecule
SynonymshCG_18375
DescriptionFUNCTION: [Protein hedgehog N-product]: The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development. .; FUNCTION: [Protein hedgehog]: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product. .

FUNCTION: [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). .; FUNCTION: [Sonic hedgehog protein N-product]: The dually lipidated sonic hedgehog protein N-product (ShhNp) is a morphogen which is essential for a variety of patterning events during development. Induces ventral cell fate in the neural tube and somites . Involved in the patterning of the anterior-posterior axis of the developing limb bud (By similarity). Essential for axon guidance (By similarity). Binds to the patched (PTCH1) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes . In the absence of SHH, PTCH1 represses the constitutive signaling activity of SMO . .

AccessionsF8WEH4
ENST00000297261.7
F8WB84
Q15465
ENST00000430104.5
D9ZGF9
C9JC48
ENST00000441114.5
ENST00000435425.1