DDIT3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045454Biological processcell redox homeostasis
GO_0007605Biological processsensory perception of sound
GO_0070059Biological processintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO_0006986Biological processresponse to unfolded protein
GO_0009948Biological processanterior/posterior axis specification
GO_0001955Biological processblood vessel maturation
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0045662Biological processnegative regulation of myoblast differentiation
GO_0006974Biological processDNA damage response
GO_0036500Biological processATF6-mediated unfolded protein response
GO_0045599Biological processnegative regulation of fat cell differentiation
GO_2001244Biological processpositive regulation of intrinsic apoptotic signaling pathway
GO_0006983Biological processER overload response
GO_0051209Biological processrelease of sequestered calcium ion into cytosol
GO_0036499Biological processPERK-mediated unfolded protein response
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0140467Biological processintegrated stress response signaling
GO_0043433Biological processnegative regulation of DNA-binding transcription factor activity
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_1990442Biological processintrinsic apoptotic signaling pathway in response to nitrosative stress
GO_0043525Biological processpositive regulation of neuron apoptotic process
GO_0042594Biological processresponse to starvation
GO_0051898Biological processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0120163Biological processnegative regulation of cold-induced thermogenesis
GO_0030968Biological processendoplasmic reticulum unfolded protein response
GO_1990874Biological processvascular associated smooth muscle cell proliferation
GO_0010506Biological processregulation of autophagy
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_1904738Biological processvascular associated smooth muscle cell migration
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0072655Biological processestablishment of protein localization to mitochondrion
GO_0032757Biological processpositive regulation of interleukin-8 production
GO_0006355Biological processregulation of DNA-templated transcription
GO_0032713Biological processnegative regulation of interleukin-4 production
GO_2000016Biological processnegative regulation of determination of dorsal identity
GO_0036119Biological processresponse to platelet-derived growth factor
GO_0032689Biological processnegative regulation of type II interferon production
GO_0060840Biological processartery development
GO_0010467Biological processgene expression
GO_0016055Biological processWnt signaling pathway
GO_0032700Biological processnegative regulation of interleukin-17 production
GO_0009611Biological processresponse to wounding
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0051726Biological processregulation of cell cycle
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0032993Cellular componentprotein-DNA complex
GO_1990617Cellular componentCHOP-ATF4 complex
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0005829Cellular componentcytosol
GO_1990622Cellular componentCHOP-ATF3 complex
GO_0005770Cellular componentlate endosome
GO_0005737Cellular componentcytoplasm
GO_0036488Cellular componentCHOP-C/EBP complex
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0008134Molecular functiontranscription factor binding
GO_0003677Molecular functionDNA binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0043522Molecular functionleucine zipper domain binding
GO_0140416Molecular functiontranscription regulator inhibitor activity
GO_0003714Molecular functiontranscription corepressor activity
GO_0042802Molecular functionidentical protein binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0140537Molecular functiontranscription regulator activator activity
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005515Molecular functionprotein binding
GO_0008140Molecular functioncAMP response element binding protein binding

IV. Literature review

[source]
Gene nameDDIT3
Protein nameDNA damage inducible transcript 3
DNA damage-inducible transcript 3 protein (DDIT-3) (C/EBP zeta) (C/EBP-homologous protein) (C/EBP-homologous protein 10) (CCAAT/enhancer-binding protein homologous protein) (Growth arrest and DNA-damage-inducible protein GADD153)
DNA damage-inducible transcript 3 protein (DDIT-3) (C/EBP zeta) (C/EBP-homologous protein) (CHOP) (C/EBP-homologous protein 10) (CHOP-10) (CCAAT/enhancer-binding protein homologous protein) (Growth arrest and DNA damage-inducible protein GADD153)
DDIT3 upstream open reading frame protein (Alternative DDIT3 protein) (AltDDIT3)
SynonymsGADD153
CHOP
hCG_39661
CHOP10
DescriptionFUNCTION: Multifunctional transcription factor in endoplasmic reticulum (ER) stress response . Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress . Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes (By similarity). Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes (By similarity). Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L . Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG) . Together with ATF4, mediates ER-mediated cell death by promoting expression of genes involved in cellular amino acid metabolic processes, mRNA translation and the unfolded protein response (UPR) in response to ER stress (By similarity). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity . Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response (By similarity). Acts as a major regulator of postnatal neovascularization through regulation of endothelial nitric oxide synthase (NOS3)-related signaling (By similarity). .

FUNCTION: Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response. .

FUNCTION: [Isoform AltDDIT3]: Product of the upstream open reading frame (uORF) of DDIT3/CHOP that is specifically produced in absence of stress, thereby preventing translation of downstream stress effector DDIT3/CHOP. .

AccessionsENST00000552740.5 [P35638-2]
ENST00000346473.8 [P35638-1]
F8W133
Q53YD1
ENST00000547303.5 [P35638-1]
ENST00000551116.5 [P35638-2]
ENST00000623876.2 [P35638-1]
P35638
P0DPQ6
ENST00000547526.1