Name | Number of supported studies | Average coverage | |
---|---|---|---|
fibroblast | 40 studies | 36% ± 17% | |
endothelial cell | 33 studies | 33% ± 14% | |
macrophage | 30 studies | 35% ± 18% | |
smooth muscle cell | 24 studies | 29% ± 11% | |
pericyte | 22 studies | 30% ± 10% | |
astrocyte | 19 studies | 42% ± 18% | |
classical monocyte | 15 studies | 25% ± 9% | |
ciliated cell | 14 studies | 33% ± 13% | |
microglial cell | 14 studies | 46% ± 13% | |
oligodendrocyte | 14 studies | 35% ± 14% | |
oligodendrocyte precursor cell | 13 studies | 36% ± 16% | |
glutamatergic neuron | 12 studies | 42% ± 25% | |
monocyte | 10 studies | 34% ± 12% | |
type I pneumocyte | 10 studies | 32% ± 11% | |
GABAergic neuron | 10 studies | 43% ± 20% | |
myofibroblast cell | 10 studies | 28% ± 13% | |
myeloid cell | 10 studies | 40% ± 13% | |
epithelial cell | 10 studies | 41% ± 17% | |
mast cell | 10 studies | 32% ± 10% | |
basal cell | 10 studies | 30% ± 11% | |
adipocyte | 10 studies | 50% ± 20% | |
endothelial cell of lymphatic vessel | 9 studies | 33% ± 11% | |
connective tissue cell | 9 studies | 23% ± 5% | |
capillary endothelial cell | 9 studies | 24% ± 6% | |
neuron | 9 studies | 36% ± 18% | |
endothelial cell of vascular tree | 9 studies | 27% ± 11% | |
non-classical monocyte | 8 studies | 27% ± 7% | |
plasma cell | 8 studies | 31% ± 14% | |
mesothelial cell | 8 studies | 33% ± 11% | |
retinal cone cell | 7 studies | 39% ± 12% | |
endothelial cell of artery | 7 studies | 21% ± 5% | |
erythrocyte | 6 studies | 42% ± 19% | |
interneuron | 6 studies | 46% ± 24% | |
club cell | 6 studies | 36% ± 10% | |
retina horizontal cell | 6 studies | 25% ± 8% | |
retinal rod cell | 6 studies | 42% ± 17% | |
Mueller cell | 6 studies | 43% ± 12% | |
type II pneumocyte | 6 studies | 34% ± 8% | |
mononuclear phagocyte | 5 studies | 32% ± 13% | |
conventional dendritic cell | 5 studies | 18% ± 2% | |
abnormal cell | 5 studies | 28% ± 14% | |
amacrine cell | 5 studies | 28% ± 5% | |
cardiac muscle cell | 5 studies | 50% ± 13% | |
dendritic cell | 5 studies | 30% ± 4% | |
vein endothelial cell | 5 studies | 30% ± 16% | |
lymphocyte | 5 studies | 27% ± 12% | |
T cell | 5 studies | 25% ± 7% | |
secretory cell | 5 studies | 22% ± 6% | |
goblet cell | 5 studies | 35% ± 19% | |
squamous epithelial cell | 4 studies | 38% ± 20% | |
cholangiocyte | 4 studies | 55% ± 23% | |
hepatocyte | 4 studies | 61% ± 31% | |
granule cell | 4 studies | 32% ± 12% | |
CD16-negative, CD56-bright natural killer cell, human | 4 studies | 23% ± 6% | |
retinal bipolar neuron | 4 studies | 26% ± 5% | |
retinal pigment epithelial cell | 4 studies | 40% ± 9% | |
luminal cell of prostate epithelium | 4 studies | 30% ± 16% | |
muscle cell | 4 studies | 53% ± 14% | |
neutrophil | 4 studies | 27% ± 7% | |
leukocyte | 4 studies | 28% ± 9% | |
alveolar macrophage | 4 studies | 38% ± 14% | |
myoepithelial cell | 4 studies | 34% ± 10% | |
hepatic stellate cell | 3 studies | 53% ± 11% | |
podocyte | 3 studies | 24% ± 1% | |
GABAergic interneuron | 3 studies | 29% ± 7% | |
glial cell | 3 studies | 30% ± 5% | |
retinal ganglion cell | 3 studies | 31% ± 6% | |
kidney loop of Henle epithelial cell | 3 studies | 32% ± 9% | |
B cell | 3 studies | 18% ± 3% | |
GABAergic amacrine cell | 3 studies | 25% ± 7% | |
OFF-bipolar cell | 3 studies | 30% ± 9% | |
ON-bipolar cell | 3 studies | 28% ± 9% | |
glycinergic amacrine cell | 3 studies | 25% ± 6% | |
rod bipolar cell | 3 studies | 43% ± 13% | |
luminal hormone-sensing cell of mammary gland | 3 studies | 18% ± 2% | |
ependymal cell | 3 studies | 38% ± 19% | |
enteroendocrine cell | 3 studies | 21% ± 3% | |
adventitial cell | 3 studies | 42% ± 6% | |
chondrocyte | 3 studies | 39% ± 23% | |
respiratory goblet cell | 3 studies | 36% ± 15% | |
Schwann cell | 3 studies | 40% ± 8% | |
brush cell | 3 studies | 32% ± 12% | |
mucus secreting cell | 3 studies | 38% ± 9% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 18 studies | 39% ± 19% | |
lung | 12 studies | 27% ± 8% | |
eye | 9 studies | 33% ± 14% | |
liver | 5 studies | 33% ± 16% | |
heart | 5 studies | 40% ± 13% | |
intestine | 4 studies | 21% ± 7% | |
adipose | 4 studies | 33% ± 11% | |
peripheral blood | 3 studies | 24% ± 3% | |
breast | 3 studies | 28% ± 9% | |
kidney | 3 studies | 29% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 6354.82 | 1445 / 1445 | 100% | 45.49 | 183 / 183 |
prostate | 100% | 5857.30 | 244 / 245 | 100% | 49.75 | 502 / 502 |
breast | 100% | 10143.25 | 459 / 459 | 100% | 47.72 | 1113 / 1118 |
ovary | 100% | 9094.79 | 180 / 180 | 99% | 33.15 | 426 / 430 |
thymus | 100% | 5872.09 | 651 / 653 | 99% | 29.81 | 598 / 605 |
lung | 100% | 9183.03 | 577 / 578 | 98% | 28.11 | 1137 / 1155 |
stomach | 99% | 5193.13 | 357 / 359 | 99% | 36.53 | 282 / 286 |
uterus | 100% | 7560.44 | 170 / 170 | 98% | 26.80 | 450 / 459 |
intestine | 100% | 5900.57 | 965 / 966 | 98% | 32.22 | 515 / 527 |
pancreas | 99% | 4777.84 | 325 / 328 | 98% | 32.18 | 175 / 178 |
bladder | 100% | 7122.05 | 21 / 21 | 97% | 21.73 | 487 / 504 |
kidney | 97% | 2997.38 | 86 / 89 | 98% | 31.55 | 884 / 901 |
skin | 100% | 8756.77 | 1808 / 1809 | 95% | 20.82 | 447 / 472 |
brain | 95% | 4200.51 | 2506 / 2642 | 99% | 40.70 | 699 / 705 |
adrenal gland | 84% | 1924.73 | 217 / 258 | 90% | 20.34 | 208 / 230 |
liver | 83% | 2169.22 | 188 / 226 | 83% | 13.65 | 338 / 406 |
adipose | 100% | 10182.54 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 10551.02 | 1335 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 4640.12 | 241 / 241 | 0% | 0 | 0 / 0 |
muscle | 100% | 14020.52 | 802 / 803 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 98% | 30.21 | 44 / 45 |
heart | 92% | 3398.01 | 793 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 91% | 19.18 | 73 / 80 |
peripheral blood | 78% | 3109.57 | 722 / 929 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 59% | 5.87 | 17 / 29 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_2000177 | Biological process | regulation of neural precursor cell proliferation |
GO_0042149 | Biological process | cellular response to glucose starvation |
GO_0071333 | Biological process | cellular response to glucose stimulus |
GO_0097150 | Biological process | neuronal stem cell population maintenance |
GO_0001544 | Biological process | initiation of primordial ovarian follicle growth |
GO_0001542 | Biological process | ovulation from ovarian follicle |
GO_0070542 | Biological process | response to fatty acid |
GO_0001547 | Biological process | antral ovarian follicle growth |
GO_1901300 | Biological process | positive regulation of hydrogen peroxide-mediated programmed cell death |
GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
GO_0014737 | Biological process | positive regulation of muscle atrophy |
GO_1903428 | Biological process | positive regulation of reactive oxygen species biosynthetic process |
GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
GO_0090090 | Biological process | negative regulation of canonical Wnt signaling pathway |
GO_0006390 | Biological process | mitochondrial transcription |
GO_1990785 | Biological process | response to water-immersion restraint stress |
GO_0043525 | Biological process | positive regulation of neuron apoptotic process |
GO_0060070 | Biological process | canonical Wnt signaling pathway |
GO_0042594 | Biological process | response to starvation |
GO_0006417 | Biological process | regulation of translation |
GO_0001556 | Biological process | oocyte maturation |
GO_0071548 | Biological process | response to dexamethasone |
GO_0030330 | Biological process | DNA damage response, signal transduction by p53 class mediator |
GO_0034599 | Biological process | cellular response to oxidative stress |
GO_0045665 | Biological process | negative regulation of neuron differentiation |
GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
GO_0010508 | Biological process | positive regulation of autophagy |
GO_1990090 | Biological process | cellular response to nerve growth factor stimulus |
GO_0097192 | Biological process | extrinsic apoptotic signaling pathway in absence of ligand |
GO_1902895 | Biological process | positive regulation of miRNA transcription |
GO_0045648 | Biological process | positive regulation of erythrocyte differentiation |
GO_0071386 | Biological process | cellular response to corticosterone stimulus |
GO_0048854 | Biological process | brain morphogenesis |
GO_0030336 | Biological process | negative regulation of cell migration |
GO_0009410 | Biological process | response to xenobiotic stimulus |
GO_0043065 | Biological process | positive regulation of apoptotic process |
GO_0045591 | Biological process | positive regulation of regulatory T cell differentiation |
GO_1904646 | Biological process | cellular response to amyloid-beta |
GO_2000353 | Biological process | positive regulation of endothelial cell apoptotic process |
GO_0033209 | Biological process | tumor necrosis factor-mediated signaling pathway |
GO_0071456 | Biological process | cellular response to hypoxia |
GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
GO_0005739 | Cellular component | mitochondrion |
GO_0032991 | Cellular component | protein-containing complex |
GO_0005654 | Cellular component | nucleoplasm |
GO_0090571 | Cellular component | RNA polymerase II transcription repressor complex |
GO_0005829 | Cellular component | cytosol |
GO_0005759 | Cellular component | mitochondrial matrix |
GO_0005737 | Cellular component | cytoplasm |
GO_0005741 | Cellular component | mitochondrial outer membrane |
GO_0000785 | Cellular component | chromatin |
GO_0005634 | Cellular component | nucleus |
GO_0003677 | Molecular function | DNA binding |
GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
GO_0001228 | Molecular function | DNA-binding transcription activator activity, RNA polymerase II-specific |
GO_0001227 | Molecular function | DNA-binding transcription repressor activity, RNA polymerase II-specific |
GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
GO_0043565 | Molecular function | sequence-specific DNA binding |
GO_0000976 | Molecular function | transcription cis-regulatory region binding |
GO_0001221 | Molecular function | transcription coregulator binding |
GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
GO_0019901 | Molecular function | protein kinase binding |
GO_0008013 | Molecular function | beta-catenin binding |
GO_0034246 | Molecular function | mitochondrial transcription factor activity |
GO_0003700 | Molecular function | DNA-binding transcription factor activity |
GO_0031490 | Molecular function | chromatin DNA binding |
GO_0005515 | Molecular function | protein binding |
Gene name | FOXO3 |
Protein name | Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1) |
Synonyms | FKHRL1 FOXO3A |
Description | FUNCTION: Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy . Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress . Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation . In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription . In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Also acts as a key regulator of regulatory T-cells (Treg) differentiation by activating expression of FOXP3 . . |
Accessions | ENST00000540898.1 [O43524-2] ENST00000406360.2 [O43524-1] O43524 ENST00000343882.10 [O43524-1] |