FOXO3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000177Biological processregulation of neural precursor cell proliferation
GO_0042149Biological processcellular response to glucose starvation
GO_0071333Biological processcellular response to glucose stimulus
GO_0097150Biological processneuronal stem cell population maintenance
GO_0001544Biological processinitiation of primordial ovarian follicle growth
GO_0001542Biological processovulation from ovarian follicle
GO_0070542Biological processresponse to fatty acid
GO_0001547Biological processantral ovarian follicle growth
GO_1901300Biological processpositive regulation of hydrogen peroxide-mediated programmed cell death
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0014737Biological processpositive regulation of muscle atrophy
GO_1903428Biological processpositive regulation of reactive oxygen species biosynthetic process
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0006390Biological processmitochondrial transcription
GO_1990785Biological processresponse to water-immersion restraint stress
GO_0043525Biological processpositive regulation of neuron apoptotic process
GO_0060070Biological processcanonical Wnt signaling pathway
GO_0042594Biological processresponse to starvation
GO_0006417Biological processregulation of translation
GO_0001556Biological processoocyte maturation
GO_0071548Biological processresponse to dexamethasone
GO_0030330Biological processDNA damage response, signal transduction by p53 class mediator
GO_0034599Biological processcellular response to oxidative stress
GO_0045665Biological processnegative regulation of neuron differentiation
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0010508Biological processpositive regulation of autophagy
GO_1990090Biological processcellular response to nerve growth factor stimulus
GO_0097192Biological processextrinsic apoptotic signaling pathway in absence of ligand
GO_1902895Biological processpositive regulation of miRNA transcription
GO_0045648Biological processpositive regulation of erythrocyte differentiation
GO_0071386Biological processcellular response to corticosterone stimulus
GO_0048854Biological processbrain morphogenesis
GO_0030336Biological processnegative regulation of cell migration
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0043065Biological processpositive regulation of apoptotic process
GO_0045591Biological processpositive regulation of regulatory T cell differentiation
GO_1904646Biological processcellular response to amyloid-beta
GO_2000353Biological processpositive regulation of endothelial cell apoptotic process
GO_0033209Biological processtumor necrosis factor-mediated signaling pathway
GO_0071456Biological processcellular response to hypoxia
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005739Cellular componentmitochondrion
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0090571Cellular componentRNA polymerase II transcription repressor complex
GO_0005829Cellular componentcytosol
GO_0005759Cellular componentmitochondrial matrix
GO_0005737Cellular componentcytoplasm
GO_0005741Cellular componentmitochondrial outer membrane
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0001221Molecular functiontranscription coregulator binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0019901Molecular functionprotein kinase binding
GO_0008013Molecular functionbeta-catenin binding
GO_0034246Molecular functionmitochondrial transcription factor activity
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0031490Molecular functionchromatin DNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFOXO3
Protein nameForkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1)
SynonymsFKHRL1
FOXO3A
DescriptionFUNCTION: Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy . Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress . Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation . In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription . In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Also acts as a key regulator of regulatory T-cells (Treg) differentiation by activating expression of FOXP3 . .

AccessionsENST00000540898.1 [O43524-2]
ENST00000406360.2 [O43524-1]
O43524
ENST00000343882.10 [O43524-1]