WWTR1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060271Biological processcilium assembly
GO_0031146Biological processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO_0016567Biological processprotein ubiquitination
GO_0006469Biological processnegative regulation of protein kinase activity
GO_0035329Biological processhippo signaling
GO_0048762Biological processmesenchymal cell differentiation
GO_0001649Biological processosteoblast differentiation
GO_0017145Biological processstem cell division
GO_0045599Biological processnegative regulation of fat cell differentiation
GO_0035264Biological processmulticellular organism growth
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0045669Biological processpositive regulation of osteoblast differentiation
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0001933Biological processnegative regulation of protein phosphorylation
GO_0060395Biological processSMAD protein signal transduction
GO_0072307Biological processregulation of metanephric nephron tubule epithelial cell differentiation
GO_0003015Biological processheart process
GO_0006355Biological processregulation of DNA-templated transcription
GO_1900182Biological processpositive regulation of protein localization to nucleus
GO_0010718Biological processpositive regulation of epithelial to mesenchymal transition
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0032835Biological processglomerulus development
GO_0060993Biological processkidney morphogenesis
GO_0001894Biological processtissue homeostasis
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005886Cellular componentplasma membrane
GO_0005654Cellular componentnucleoplasm
GO_0016604Cellular componentnuclear body
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0003714Molecular functiontranscription corepressor activity
GO_0003712Molecular functiontranscription coregulator activity
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameWWTR1
Protein nameWW domain containing transcription regulator 1
WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif)
SynonymsTAZ
DescriptionFUNCTION: Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis . The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ . WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation . In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation . Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex . Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition . .

AccessionsC9J337
C9JR84
ENST00000485352.1
Q9GZV5
ENST00000479238.1
ENST00000472417.1
H7C4Z7
ENST00000467467.5
ENST00000475579.1
ENST00000494754.1
C9J038
ENST00000460517.1
H7C4Q0
ENST00000465804.5
ENST00000360632.8
ENST00000471586.5
C9JQS8
C9J588