Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 52 studies | 47% ± 16% | |
fibroblast | 31 studies | 29% ± 12% | |
endothelial cell of lymphatic vessel | 25 studies | 45% ± 17% | |
smooth muscle cell | 22 studies | 27% ± 9% | |
astrocyte | 15 studies | 31% ± 16% | |
capillary endothelial cell | 15 studies | 37% ± 16% | |
pericyte | 15 studies | 28% ± 16% | |
endothelial cell of vascular tree | 15 studies | 47% ± 19% | |
vein endothelial cell | 14 studies | 49% ± 19% | |
basal cell | 14 studies | 29% ± 13% | |
endothelial cell of artery | 13 studies | 45% ± 11% | |
myofibroblast cell | 11 studies | 26% ± 11% | |
type I pneumocyte | 10 studies | 33% ± 9% | |
epithelial cell | 9 studies | 32% ± 13% | |
adipocyte | 9 studies | 31% ± 10% | |
type II pneumocyte | 8 studies | 34% ± 11% | |
connective tissue cell | 8 studies | 31% ± 16% | |
ciliated cell | 8 studies | 35% ± 16% | |
club cell | 6 studies | 44% ± 17% | |
cardiac muscle cell | 5 studies | 23% ± 3% | |
secretory cell | 5 studies | 26% ± 20% | |
GABAergic neuron | 4 studies | 33% ± 10% | |
retinal pigment epithelial cell | 4 studies | 55% ± 10% | |
glutamatergic neuron | 4 studies | 34% ± 15% | |
oligodendrocyte | 4 studies | 25% ± 10% | |
respiratory goblet cell | 4 studies | 36% ± 17% | |
renal principal cell | 4 studies | 36% ± 13% | |
ionocyte | 3 studies | 23% ± 4% | |
cholangiocyte | 3 studies | 48% ± 25% | |
endothelial cell of sinusoid | 3 studies | 47% ± 31% | |
glomerular endothelial cell | 3 studies | 21% ± 6% | |
endocardial cell | 3 studies | 61% ± 7% | |
lymphocyte | 3 studies | 31% ± 16% | |
abnormal cell | 3 studies | 49% ± 25% | |
oligodendrocyte precursor cell | 3 studies | 20% ± 2% | |
ependymal cell | 3 studies | 57% ± 9% | |
chondrocyte | 3 studies | 30% ± 5% | |
myoepithelial cell | 3 studies | 32% ± 16% | |
kidney distal convoluted tubule epithelial cell | 3 studies | 26% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
ovary | 100% | 8410.14 | 180 / 180 | 100% | 36.13 | 428 / 430 |
kidney | 100% | 5579.85 | 89 / 89 | 99% | 78.91 | 888 / 901 |
prostate | 100% | 7507.31 | 244 / 245 | 98% | 28.82 | 490 / 502 |
lung | 100% | 8306.24 | 576 / 578 | 97% | 39.38 | 1124 / 1155 |
breast | 100% | 7732.82 | 459 / 459 | 97% | 36.75 | 1079 / 1118 |
esophagus | 100% | 12217.87 | 1444 / 1445 | 96% | 49.42 | 175 / 183 |
uterus | 100% | 8898.26 | 170 / 170 | 94% | 33.54 | 430 / 459 |
skin | 100% | 4756.48 | 1801 / 1809 | 93% | 72.15 | 441 / 472 |
thymus | 100% | 6318.85 | 652 / 653 | 91% | 26.14 | 553 / 605 |
bladder | 100% | 12136.57 | 21 / 21 | 74% | 17.97 | 371 / 504 |
pancreas | 72% | 1634.69 | 235 / 328 | 94% | 38.64 | 168 / 178 |
stomach | 89% | 5637.95 | 319 / 359 | 71% | 22.56 | 203 / 286 |
adrenal gland | 95% | 2417.27 | 246 / 258 | 59% | 10.72 | 136 / 230 |
brain | 59% | 1657.06 | 1546 / 2642 | 90% | 42.55 | 638 / 705 |
intestine | 92% | 10296.24 | 891 / 966 | 54% | 13.73 | 285 / 527 |
adipose | 100% | 8185.42 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 12485.78 | 1335 / 1335 | 0% | 0 | 0 / 0 |
heart | 95% | 3924.10 | 819 / 861 | 0% | 0 | 0 / 0 |
spleen | 92% | 2644.55 | 221 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 89% | 25.79 | 40 / 45 |
liver | 25% | 456.58 | 57 / 226 | 57% | 17.91 | 230 / 406 |
muscle | 47% | 982.54 | 374 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 34% | 6.79 | 27 / 80 |
peripheral blood | 0% | 2.81 | 1 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0060271 | Biological process | cilium assembly |
GO_0031146 | Biological process | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
GO_0016567 | Biological process | protein ubiquitination |
GO_0006469 | Biological process | negative regulation of protein kinase activity |
GO_0035329 | Biological process | hippo signaling |
GO_0048762 | Biological process | mesenchymal cell differentiation |
GO_0001649 | Biological process | osteoblast differentiation |
GO_0017145 | Biological process | stem cell division |
GO_0045599 | Biological process | negative regulation of fat cell differentiation |
GO_0035264 | Biological process | multicellular organism growth |
GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
GO_0045669 | Biological process | positive regulation of osteoblast differentiation |
GO_0090090 | Biological process | negative regulation of canonical Wnt signaling pathway |
GO_0001933 | Biological process | negative regulation of protein phosphorylation |
GO_0060395 | Biological process | SMAD protein signal transduction |
GO_0072307 | Biological process | regulation of metanephric nephron tubule epithelial cell differentiation |
GO_0003015 | Biological process | heart process |
GO_0006355 | Biological process | regulation of DNA-templated transcription |
GO_1900182 | Biological process | positive regulation of protein localization to nucleus |
GO_0010718 | Biological process | positive regulation of epithelial to mesenchymal transition |
GO_0008284 | Biological process | positive regulation of cell population proliferation |
GO_0032835 | Biological process | glomerulus development |
GO_0060993 | Biological process | kidney morphogenesis |
GO_0001894 | Biological process | tissue homeostasis |
GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
GO_0005886 | Cellular component | plasma membrane |
GO_0005654 | Cellular component | nucleoplasm |
GO_0016604 | Cellular component | nuclear body |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0005667 | Cellular component | transcription regulator complex |
GO_0005634 | Cellular component | nucleus |
GO_0042803 | Molecular function | protein homodimerization activity |
GO_0003714 | Molecular function | transcription corepressor activity |
GO_0003712 | Molecular function | transcription coregulator activity |
GO_0003713 | Molecular function | transcription coactivator activity |
GO_0005515 | Molecular function | protein binding |
Gene name | WWTR1 |
Protein name | WW domain containing transcription regulator 1 WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif) |
Synonyms | TAZ |
Description | FUNCTION: Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis . The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ . WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation . In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation . Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex . Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition . . |
Accessions | C9J337 C9JR84 ENST00000485352.1 Q9GZV5 ENST00000479238.1 ENST00000472417.1 H7C4Z7 ENST00000467467.5 ENST00000475579.1 ENST00000494754.1 C9J038 ENST00000460517.1 H7C4Q0 ENST00000465804.5 ENST00000360632.8 ENST00000471586.5 C9JQS8 C9J588 |