I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| oligodendrocyte | 4 studies | 29% ± 13% | |
| fibroblast | 3 studies | 38% ± 20% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| oligodendrocyte | 4 studies | 29% ± 13% | |
| fibroblast | 3 studies | 38% ± 20% |
Insufficient scRNA-seq data for expression of GREM1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| intestine | 98% | 9363.30 | 947 / 966 | 83% | 33.43 | 436 / 527 |
| esophagus | 92% | 10084.32 | 1329 / 1445 | 84% | 38.33 | 153 / 183 |
| stomach | 89% | 7653.15 | 321 / 359 | 84% | 49.27 | 239 / 286 |
| breast | 46% | 1272.09 | 210 / 459 | 74% | 13.27 | 831 / 1118 |
| prostate | 51% | 2236.85 | 126 / 245 | 50% | 5.99 | 252 / 502 |
| pancreas | 13% | 171.28 | 41 / 328 | 85% | 45.89 | 152 / 178 |
| uterus | 55% | 2793.55 | 93 / 170 | 39% | 9.58 | 179 / 459 |
| bladder | 24% | 606.29 | 5 / 21 | 64% | 16.48 | 323 / 504 |
| lung | 12% | 352.16 | 69 / 578 | 74% | 23.20 | 851 / 1155 |
| skin | 64% | 26897.41 | 1159 / 1809 | 9% | 0.86 | 43 / 472 |
| brain | 46% | 898.68 | 1226 / 2642 | 8% | 0.74 | 59 / 705 |
| tonsil | 0% | 0 | 0 / 0 | 51% | 8.39 | 23 / 45 |
| adipose | 47% | 3743.88 | 565 / 1204 | 0% | 0 | 0 / 0 |
| thymus | 22% | 432.46 | 141 / 653 | 5% | 0.78 | 33 / 605 |
| ovary | 2% | 29.67 | 4 / 180 | 12% | 1.41 | 53 / 430 |
| kidney | 8% | 180.91 | 7 / 89 | 5% | 0.55 | 47 / 901 |
| lymph node | 0% | 0 | 0 / 0 | 10% | 1.05 | 3 / 29 |
| liver | 2% | 37.08 | 5 / 226 | 8% | 0.90 | 31 / 406 |
| blood vessel | 9% | 188.61 | 123 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 4% | 69.92 | 10 / 241 | 0% | 0 | 0 / 0 |
| heart | 4% | 65.09 | 35 / 861 | 0% | 0 | 0 / 0 |
| adrenal gland | 1% | 7.38 | 2 / 258 | 3% | 0.81 | 7 / 230 |
| muscle | 0% | 11.14 | 4 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 1.47 | 1 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_1901224 | Biological process | positive regulation of non-canonical NF-kappaB signal transduction |
| GO_0009954 | Biological process | proximal/distal pattern formation |
| GO_0060392 | Biological process | negative regulation of SMAD protein signal transduction |
| GO_0033689 | Biological process | negative regulation of osteoblast proliferation |
| GO_0045766 | Biological process | positive regulation of angiogenesis |
| GO_0055007 | Biological process | cardiac muscle cell differentiation |
| GO_2000273 | Biological process | positive regulation of signaling receptor activity |
| GO_0009887 | Biological process | animal organ morphogenesis |
| GO_0007165 | Biological process | signal transduction |
| GO_0002042 | Biological process | cell migration involved in sprouting angiogenesis |
| GO_0060173 | Biological process | limb development |
| GO_0030514 | Biological process | negative regulation of BMP signaling pathway |
| GO_0090090 | Biological process | negative regulation of canonical Wnt signaling pathway |
| GO_0032872 | Biological process | regulation of stress-activated MAPK cascade |
| GO_0002092 | Biological process | positive regulation of receptor internalization |
| GO_0007267 | Biological process | cell-cell signaling |
| GO_0060676 | Biological process | ureteric bud formation |
| GO_0032331 | Biological process | negative regulation of chondrocyte differentiation |
| GO_0072331 | Biological process | signal transduction by p53 class mediator |
| GO_0090291 | Biological process | negative regulation of osteoclast proliferation |
| GO_0043066 | Biological process | negative regulation of apoptotic process |
| GO_0030326 | Biological process | embryonic limb morphogenesis |
| GO_0030502 | Biological process | negative regulation of bone mineralization |
| GO_0051973 | Biological process | positive regulation of telomerase activity |
| GO_0045668 | Biological process | negative regulation of osteoblast differentiation |
| GO_0060379 | Biological process | cardiac muscle cell myoblast differentiation |
| GO_0051893 | Biological process | regulation of focal adhesion assembly |
| GO_1900158 | Biological process | negative regulation of bone mineralization involved in bone maturation |
| GO_0090190 | Biological process | positive regulation of branching involved in ureteric bud morphogenesis |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0046851 | Biological process | negative regulation of bone remodeling |
| GO_1900155 | Biological process | negative regulation of bone trabecula formation |
| GO_0030199 | Biological process | collagen fibril organization |
| GO_0000902 | Biological process | cell morphogenesis |
| GO_1900086 | Biological process | positive regulation of peptidyl-tyrosine autophosphorylation |
| GO_0010717 | Biological process | regulation of epithelial to mesenchymal transition |
| GO_0090027 | Biological process | negative regulation of monocyte chemotaxis |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0048263 | Biological process | determination of dorsal identity |
| GO_0003337 | Biological process | mesenchymal to epithelial transition involved in metanephros morphogenesis |
| GO_0038098 | Biological process | sequestering of BMP from receptor via BMP binding |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0030308 | Biological process | negative regulation of cell growth |
| GO_0005615 | Cellular component | extracellular space |
| GO_0062023 | Cellular component | collagen-containing extracellular matrix |
| GO_0009986 | Cellular component | cell surface |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0048018 | Molecular function | receptor ligand activity |
| GO_0043184 | Molecular function | vascular endothelial growth factor receptor 2 binding |
| GO_0016015 | Molecular function | morphogen activity |
| GO_0036122 | Molecular function | BMP binding |
| GO_0030297 | Molecular function | transmembrane receptor protein tyrosine kinase activator activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0005125 | Molecular function | cytokine activity |
| Gene name | GREM1 |
| Protein name | Gremlin-1 Gremlin Gremlin 1, DAN family BMP antagonist (Gremlin-1) Gremlin-1 (Cell proliferation-inducing gene 2 protein) (Cysteine knot superfamily 1, BMP antagonist 1) (DAN domain family member 2) (Down-regulated in Mos-transformed cells protein) (Increased in high glucose protein 2) (IHG-2) |
| Synonyms | DRM PIG2 CKTSF1B1 DAND2 hCG_1811964 |
| Description | FUNCTION: Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity). Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro) . Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed (By similarity). . |
| Accessions | ENST00000632478.1 [O60565-2] ENST00000560677.5 H0YLY2 O60565 ENST00000651154.1 [O60565-1] ENST00000652365.1 [O60565-1] B3KTR9 ENST00000651081.1 [O60565-1] A6XAA7 ENST00000651986.1 [O60565-1] ENST00000300177.8 [O60565-1] ENST00000560830.1 [O60565-2] ENST00000322805.5 [O60565-2] ENST00000633992.1 |
