NKX2-5 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of NKX2-5 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NKX2-5 at tissue level.

III. Associated gene sets

GO_0006366Biological processtranscription by RNA polymerase II
GO_0060929Biological processatrioventricular node cell fate commitment
GO_0001947Biological processheart looping
GO_0003285Biological processseptum secundum development
GO_0030878Biological processthyroid gland development
GO_0060048Biological processcardiac muscle contraction
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0055008Biological processcardiac muscle tissue morphogenesis
GO_0060261Biological processpositive regulation of transcription initiation by RNA polymerase II
GO_0043066Biological processnegative regulation of apoptotic process
GO_0035050Biological processembryonic heart tube development
GO_1903779Biological processregulation of cardiac conduction
GO_0055014Biological processatrial cardiac muscle cell development
GO_0060037Biological processpharyngeal system development
GO_0055015Biological processventricular cardiac muscle cell development
GO_0050673Biological processepithelial cell proliferation
GO_0003161Biological processcardiac conduction system development
GO_0060928Biological processatrioventricular node cell development
GO_0030855Biological processepithelial cell differentiation
GO_0060347Biological processheart trabecula formation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0010628Biological processpositive regulation of gene expression
GO_0055005Biological processventricular cardiac myofibril assembly
GO_0051891Biological processpositive regulation of cardioblast differentiation
GO_0050679Biological processpositive regulation of epithelial cell proliferation
GO_0010765Biological processpositive regulation of sodium ion transport
GO_0007512Biological processadult heart development
GO_0006355Biological processregulation of DNA-templated transcription
GO_0060412Biological processventricular septum morphogenesis
GO_0003342Biological processproepicardium development
GO_0010667Biological processnegative regulation of cardiac muscle cell apoptotic process
GO_0003166Biological processbundle of His development
GO_0003007Biological processheart morphogenesis
GO_0003211Biological processcardiac ventricle formation
GO_0003148Biological processoutflow tract septum morphogenesis
GO_0030097Biological processhemopoiesis
GO_0055013Biological processcardiac muscle cell development
GO_0060411Biological processcardiac septum morphogenesis
GO_0003168Biological processPurkinje myocyte differentiation
GO_0001570Biological processvasculogenesis
GO_0003180Biological processaortic valve morphogenesis
GO_0060971Biological processembryonic heart tube left/right pattern formation
GO_0060038Biological processcardiac muscle cell proliferation
GO_0010832Biological processnegative regulation of myotube differentiation
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0003221Biological processright ventricular cardiac muscle tissue morphogenesis
GO_1904036Biological processnegative regulation of epithelial cell apoptotic process
GO_1904019Biological processepithelial cell apoptotic process
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0007507Biological processheart development
GO_0060413Biological processatrial septum morphogenesis
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0048536Biological processspleen development
GO_0060043Biological processregulation of cardiac muscle cell proliferation
GO_0003228Biological processatrial cardiac muscle tissue development
GO_0030154Biological processcell differentiation
GO_0045823Biological processpositive regulation of heart contraction
GO_0003350Biological processpulmonary myocardium development
GO_0003278Biological processapoptotic process involved in heart morphogenesis
GO_0045666Biological processpositive regulation of neuron differentiation
GO_0003162Biological processatrioventricular node development
GO_0003222Biological processventricular trabecula myocardium morphogenesis
GO_0055117Biological processregulation of cardiac muscle contraction
GO_0032993Cellular componentprotein-DNA complex
GO_1990664Cellular componentNkx-2.5 complex
GO_0005634Cellular componentnucleus
GO_0005654Cellular componentnucleoplasm
GO_0032991Cellular componentprotein-containing complex
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0043565Molecular functionsequence-specific DNA binding
GO_0003682Molecular functionchromatin binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0001216Molecular functionDNA-binding transcription activator activity
GO_0005515Molecular functionprotein binding
GO_0003677Molecular functionDNA binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837Molecular functionsequence-specific double-stranded DNA binding

IV. Literature review

[source]
Gene nameNKX2-5
Protein nameNK2 homeobox 5
NK2 transcription factor related locus 5 isoform 2
Homeobox protein Nkx-2.5 (Cardiac-specific homeobox) (Homeobox protein CSX) (Homeobox protein NK-2 homolog E)
Homeobox protein Nkx-2.5 (Homeobox protein NK-2 homolog E)
SynonymsNKX2E
CSX
NKX2.5
DescriptionFUNCTION: Transcription factor required for the development of the heart and the spleen . During heart development, acts as a transcriptional activator of NPPA/ANF in cooperation with GATA4 (By similarity). May cooperate with TBX2 to negatively modulate expression of NPPA/ANF in the atrioventricular canal (By similarity). Binds to the core DNA motif of NPPA promoter . Together with PBX1, required for spleen development through a mechanism that involves CDKN2B repression . Positively regulates transcription of genes such as COL3A1 and MMP2, resulting in increased pulmonary endothelial fibrosis in response to hypoxia . .

AccessionsA0A0S2Z383
ENST00000329198.5 [P52952-1]
A1ECD1
A1ECB1
ENST00000521848.1 [P52952-2]
P52952
A1ECB7
A0A0S2Z3K2
E5RH49
A1ECB6
A1ECB8
ENST00000424406.2 [P52952-3]
ENST00000517440.1
A1ECB2