LIMD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035278Biological processmiRNA-mediated gene silencing by inhibition of translation
GO_0033962Biological processP-body assembly
GO_0007010Biological processcytoskeleton organization
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0035331Biological processnegative regulation of hippo signaling
GO_0035195Biological processmiRNA-mediated post-transcriptional gene silencing
GO_0001666Biological processresponse to hypoxia
GO_0045668Biological processnegative regulation of osteoblast differentiation
GO_0006355Biological processregulation of DNA-templated transcription
GO_0008360Biological processregulation of cell shape
GO_0016310Biological processphosphorylation
GO_0002076Biological processosteoblast development
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0016477Biological processcell migration
GO_0005886Cellular componentplasma membrane
GO_0005654Cellular componentnucleoplasm
GO_0005925Cellular componentfocal adhesion
GO_0000932Cellular componentP-body
GO_0005829Cellular componentcytosol
GO_0005912Cellular componentadherens junction
GO_0005737Cellular componentcytoplasm
GO_0016442Cellular componentRISC complex
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0003714Molecular functiontranscription corepressor activity
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLIMD1
Protein nameLIM domain-containing protein 1
Synonyms
DescriptionFUNCTION: Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. .

AccessionsENST00000440097.5
ENST00000273317.5
Q9UGP4
C9JRJ5