CDH2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
astrocyte	21 studies	49% ± 18%	Explore
endothelial cell	15 studies	35% ± 21%	Explore
oligodendrocyte precursor cell	15 studies	44% ± 17%	Explore
glutamatergic neuron	13 studies	59% ± 22%	Explore
GABAergic neuron	11 studies	53% ± 20%	Explore
oligodendrocyte	11 studies	30% ± 12%	Explore
neuron	9 studies	45% ± 17%	Explore
interneuron	7 studies	59% ± 15%	Explore
retinal cone cell	7 studies	62% ± 24%	Explore
retinal rod cell	6 studies	52% ± 25%	Explore
cardiac muscle cell	6 studies	78% ± 15%	Explore
Mueller cell	6 studies	63% ± 20%	Explore
hepatocyte	5 studies	49% ± 20%	Explore
epithelial cell of proximal tubule	4 studies	22% ± 5%	Explore
granule cell	4 studies	52% ± 7%	Explore
amacrine cell	4 studies	31% ± 20%	Explore
connective tissue cell	3 studies	43% ± 23%	Explore
progenitor cell	3 studies	48% ± 18%	Explore
GABAergic interneuron	3 studies	56% ± 13%	Explore
glial cell	3 studies	39% ± 16%	Explore
OFF-bipolar cell	3 studies	48% ± 22%	Explore
abnormal cell	3 studies	43% ± 8%	Explore
fibroblast	3 studies	40% ± 18%	Explore
neural progenitor cell	3 studies	61% ± 25%	Explore
ependymal cell	3 studies	57% ± 12%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	18 studies	44% ± 20%	Explore
eye	9 studies	38% ± 22%	Explore
heart	6 studies	30% ± 13%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	2746.00	2636 / 2642	100%	60.08	702 / 705
liver	100%	2300.30	226 / 226	94%	28.25	382 / 406
adrenal gland	100%	9843.30	258 / 258	81%	31.69	186 / 230
kidney	84%	1044.54	75 / 89	86%	33.92	779 / 901
ovary	63%	649.31	114 / 180	72%	25.73	308 / 430
heart	99%	11815.48	854 / 861	0%	0	0 / 0
spleen	93%	1038.37	224 / 241	0%	0	0 / 0
stomach	79%	773.40	282 / 359	6%	0.91	16 / 286
thymus	11%	105.58	69 / 653	73%	24.02	444 / 605
skin	27%	815.37	491 / 1809	47%	12.99	221 / 472
blood vessel	71%	2248.72	954 / 1335	0%	0	0 / 0
esophagus	56%	873.06	809 / 1445	8%	0.90	15 / 183
intestine	52%	533.63	504 / 966	6%	0.93	31 / 527
uterus	25%	238.61	42 / 170	27%	8.28	123 / 459
prostate	29%	259.51	70 / 245	11%	1.24	55 / 502
pancreas	0%	1.61	1 / 328	31%	4.30	55 / 178
bladder	14%	85.24	3 / 21	8%	1.90	38 / 504
breast	0%	5.10	2 / 459	13%	4.07	147 / 1118
lung	2%	21.31	10 / 578	11%	2.33	124 / 1155
lymph node	0%	0	0 / 0	7%	1.58	2 / 29
eye	0%	0	0 / 0	5%	0.69	4 / 80
tonsil	0%	0	0 / 0	2%	0.12	1 / 45
adipose	1%	4.59	8 / 1204	0%	0	0 / 0
muscle	0%	2.76	3 / 803	0%	0	0 / 0
peripheral blood	0%	2.35	1 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0007043	Biological process	cell-cell junction assembly
GO_0034332	Biological process	adherens junction organization
GO_0072659	Biological process	protein localization to plasma membrane
GO_0097150	Biological process	neuronal stem cell population maintenance
GO_1902897	Biological process	regulation of postsynaptic density protein 95 clustering
GO_0060019	Biological process	radial glial cell differentiation
GO_0010001	Biological process	glial cell differentiation
GO_0007275	Biological process	multicellular organism development
GO_2000809	Biological process	positive regulation of synaptic vesicle clustering
GO_0007155	Biological process	cell adhesion
GO_0051146	Biological process	striated muscle cell differentiation
GO_0043410	Biological process	positive regulation of MAPK cascade
GO_0048872	Biological process	homeostasis of number of cells
GO_0090090	Biological process	negative regulation of canonical Wnt signaling pathway
GO_0044331	Biological process	cell-cell adhesion mediated by cadherin
GO_0014032	Biological process	neural crest cell development
GO_0097118	Biological process	neuroligin clustering involved in postsynaptic membrane assembly
GO_0007156	Biological process	homophilic cell adhesion via plasma membrane adhesion molecules
GO_0060563	Biological process	neuroepithelial cell differentiation
GO_0035995	Biological process	detection of muscle stretch
GO_0003323	Biological process	type B pancreatic cell development
GO_0016339	Biological process	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
GO_0090497	Biological process	mesenchymal cell migration
GO_0048854	Biological process	brain morphogenesis
GO_0070445	Biological process	regulation of oligodendrocyte progenitor proliferation
GO_0097091	Biological process	synaptic vesicle clustering
GO_0021987	Biological process	cerebral cortex development
GO_0000902	Biological process	cell morphogenesis
GO_0048514	Biological process	blood vessel morphogenesis
GO_0007416	Biological process	synapse assembly
GO_0098609	Biological process	cell-cell adhesion
GO_0007157	Biological process	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO_0016477	Biological process	cell migration
GO_0016324	Cellular component	apical plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0005916	Cellular component	fascia adherens
GO_0048787	Cellular component	presynaptic active zone membrane
GO_0042383	Cellular component	sarcolemma
GO_0030864	Cellular component	cortical actin cytoskeleton
GO_0062023	Cellular component	collagen-containing extracellular matrix
GO_0043005	Cellular component	neuron projection
GO_0016342	Cellular component	catenin complex
GO_0005925	Cellular component	focal adhesion
GO_0005911	Cellular component	cell-cell junction
GO_0009986	Cellular component	cell surface
GO_0044853	Cellular component	plasma membrane raft
GO_0005788	Cellular component	endoplasmic reticulum lumen
GO_0005912	Cellular component	adherens junction
GO_0099634	Cellular component	postsynaptic specialization membrane
GO_0014069	Cellular component	postsynaptic density
GO_0005737	Cellular component	cytoplasm
GO_0030054	Cellular component	cell junction
GO_0030057	Cellular component	desmosome
GO_0016327	Cellular component	apicolateral plasma membrane
GO_0030027	Cellular component	lamellipodium
GO_0045177	Cellular component	apical part of cell
GO_0014704	Cellular component	intercalated disc
GO_0016323	Cellular component	basolateral plasma membrane
GO_0045294	Molecular function	alpha-catenin binding
GO_0019903	Molecular function	protein phosphatase binding
GO_0045296	Molecular function	cadherin binding
GO_0019901	Molecular function	protein kinase binding
GO_0008013	Molecular function	beta-catenin binding
GO_0042802	Molecular function	identical protein binding
GO_0045295	Molecular function	gamma-catenin binding
GO_0003723	Molecular function	RNA binding
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CDH2
Protein name	Cadherin-2 (CDw325) (Neural cadherin) (N-cadherin) (CD antigen CD325) Cadherin-2 (Neural cadherin) Cadherin 2
Synonyms	NCAD CDHN
Description	FUNCTION: Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. Plays a role in cell-to-cell junction formation between pancreatic beta cells and neural crest stem (NCS) cells, promoting the formation of processes by NCS cells (By similarity). Required for proper neurite branching. Required for pre- and postsynaptic organization (By similarity). CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. . FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. .
Accessions	C9J8J8 A0A6Q8PF58 ENST00000675688.1 A0A6Q8PHJ8 ENST00000675173.1 ENST00000430882.6 ENST00000676445.1 ENST00000413878.2 C9J126 ENST00000269141.8 [P19022-1] C9JMH2 A0A6Q8PG20 ENST00000418492.5 ENST00000675708.1 P19022 ENST00000399380.7 [P19022-2]

CDH2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review