LATS1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0046620Biological processregulation of organ growth
GO_0017015Biological processregulation of transforming growth factor beta receptor signaling pathway
GO_0030216Biological processkeratinocyte differentiation
GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0035329Biological processhippo signaling
GO_0030833Biological processregulation of actin filament polymerization
GO_2000058Biological processregulation of ubiquitin-dependent protein catabolic process
GO_0001827Biological processinner cell mass cell fate commitment
GO_0033146Biological processregulation of intracellular estrogen receptor signaling pathway
GO_0033138Biological processpositive regulation of peptidyl-serine phosphorylation
GO_0051301Biological processcell division
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0051220Biological processcytoplasmic sequestering of protein
GO_0060644Biological processmammary gland epithelial cell differentiation
GO_0009755Biological processhormone-mediated signaling pathway
GO_0043254Biological processregulation of protein-containing complex assembly
GO_0000086Biological processG2/M transition of mitotic cell cycle
GO_0000819Biological processsister chromatid segregation
GO_1900181Biological processnegative regulation of protein localization to nucleus
GO_0006468Biological processprotein phosphorylation
GO_0045736Biological processnegative regulation of cyclin-dependent protein serine/threonine kinase activity
GO_0001828Biological processinner cell mass cellular morphogenesis
GO_0043065Biological processpositive regulation of apoptotic process
GO_0000082Biological processG1/S transition of mitotic cell cycle
GO_0030496Cellular componentmidbody
GO_0000922Cellular componentspindle pole
GO_0005813Cellular componentcentrosome
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0106310Molecular functionprotein serine kinase activity
GO_0019901Molecular functionprotein kinase binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0000287Molecular functionmagnesium ion binding
GO_0030331Molecular functionnuclear estrogen receptor binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLATS1
Protein nameSerine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts)
LATS1 protein (Large tumor suppressor kinase 1)
Large tumor suppressor kinase 1
SynonymsWARTS
DescriptionFUNCTION: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function. Plays a role in mammary gland epithelial cell differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 . .

AccessionsENST00000458696.2
ENST00000543571.6 [O95835-1]
O95835
ENST00000392273.7 [O95835-2]
ENST00000253339.9 [O95835-1]
Q6PJG3
ENST00000441107.5
H0YG09
ENST00000542720.1