I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 6 studies | 20% ± 4% | |
| epithelial cell | 4 studies | 26% ± 6% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 6 studies | 20% ± 4% | |
| epithelial cell | 4 studies | 26% ± 6% |
Insufficient scRNA-seq data for expression of FRMD8 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| uterus | 100% | 2675.51 | 170 / 170 | 100% | 75.99 | 459 / 459 |
| esophagus | 100% | 3212.11 | 1444 / 1445 | 100% | 72.59 | 183 / 183 |
| ovary | 100% | 2039.49 | 180 / 180 | 100% | 43.72 | 429 / 430 |
| skin | 100% | 4694.60 | 1809 / 1809 | 100% | 87.62 | 470 / 472 |
| lung | 100% | 3911.13 | 577 / 578 | 100% | 53.43 | 1151 / 1155 |
| breast | 100% | 3556.79 | 459 / 459 | 99% | 49.42 | 1110 / 1118 |
| intestine | 100% | 2605.97 | 966 / 966 | 99% | 39.54 | 522 / 527 |
| thymus | 100% | 3273.74 | 652 / 653 | 99% | 37.34 | 600 / 605 |
| bladder | 100% | 2496.52 | 21 / 21 | 99% | 54.68 | 499 / 504 |
| stomach | 100% | 1807.28 | 359 / 359 | 99% | 40.54 | 283 / 286 |
| pancreas | 99% | 2271.17 | 324 / 328 | 100% | 56.04 | 178 / 178 |
| prostate | 100% | 2920.73 | 245 / 245 | 98% | 27.14 | 492 / 502 |
| kidney | 100% | 2482.11 | 89 / 89 | 97% | 34.81 | 877 / 901 |
| brain | 95% | 1386.62 | 2521 / 2642 | 100% | 35.77 | 705 / 705 |
| adrenal gland | 100% | 2887.98 | 258 / 258 | 92% | 27.89 | 212 / 230 |
| liver | 93% | 1218.22 | 211 / 226 | 91% | 23.48 | 371 / 406 |
| adipose | 100% | 3376.05 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 59.06 | 29 / 29 |
| spleen | 100% | 7220.70 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 87.36 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 38.33 | 1 / 1 |
| blood vessel | 100% | 1850.39 | 1330 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 99% | 44.97 | 79 / 80 |
| heart | 98% | 1632.59 | 841 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 93% | 2422.92 | 863 / 929 | 0% | 0 | 0 / 0 |
| muscle | 83% | 1356.03 | 664 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0072659 | Biological process | protein localization to plasma membrane |
| GO_0032760 | Biological process | positive regulation of tumor necrosis factor production |
| GO_0090090 | Biological process | negative regulation of canonical Wnt signaling pathway |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0034451 | Cellular component | centriolar satellite |
| GO_0005515 | Molecular function | protein binding |
| Gene name | FRMD8 |
| Protein name | FERM domain containing 8 FERM domain-containing protein 8 (Band4.1 inhibitor LRP interactor) (Bili) (iRhom tail-associated protein) (iTAP) FERM domain containing 8 (FRMD8 protein) |
| Synonyms | FKSG44 |
| Description | FUNCTION: Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface . Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 . . |
| Accessions | ENST00000525156.1 E9PS62 Q8N4M4 Q9BZ67 ENST00000355991.9 [Q9BZ67-2] ENST00000533782.5 ENST00000531296.1 E9PRA3 ENST00000416776.6 [Q9BZ67-3] ENST00000317568.10 [Q9BZ67-1] ENST00000526201.1 E9PRP1 |
