NOG | OmnibusX

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NOG at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	93%	205.95	2447 / 2642	98%	25.87	690 / 705
lung	86%	69.83	497 / 578	41%	1.75	470 / 1155
thymus	69%	38.32	453 / 653	53%	2.07	321 / 605
prostate	80%	77.35	197 / 245	29%	0.49	147 / 502
kidney	61%	32.22	54 / 89	38%	3.19	344 / 901
muscle	96%	173.77	767 / 803	0%	0	0 / 0
bladder	76%	70.67	16 / 21	17%	1.87	87 / 504
blood vessel	85%	96.35	1138 / 1335	0%	0	0 / 0
stomach	61%	66.14	220 / 359	21%	0.74	60 / 286
pancreas	2%	0.90	7 / 328	75%	3.66	133 / 178
esophagus	59%	50.22	858 / 1445	17%	0.43	31 / 183
ovary	8%	3.44	15 / 180	60%	3.44	259 / 430
skin	54%	69.61	973 / 1809	14%	1.73	66 / 472
breast	49%	26.10	226 / 459	17%	0.67	191 / 1118
uterus	29%	49.00	49 / 170	31%	2.75	144 / 459
intestine	40%	23.37	388 / 966	12%	0.38	64 / 527
adipose	48%	38.61	582 / 1204	0%	0	0 / 0
adrenal gland	7%	2.79	19 / 258	30%	5.27	68 / 230
peripheral blood	27%	17.10	252 / 929	0%	0	0 / 0
spleen	24%	12.11	59 / 241	0%	0	0 / 0
heart	24%	14.15	209 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	21%	0.56	6 / 29
tonsil	0%	0	0 / 0	18%	7.09	8 / 45
liver	4%	2.35	10 / 226	3%	0.15	11 / 406
eye	0%	0	0 / 0	3%	0.04	2 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0050673	Biological process	epithelial cell proliferation
GO_0001839	Biological process	neural plate morphogenesis
GO_0061384	Biological process	heart trabecula morphogenesis
GO_1904888	Biological process	cranial skeletal system development
GO_0001837	Biological process	epithelial to mesenchymal transition
GO_0007224	Biological process	smoothened signaling pathway
GO_0035640	Biological process	exploration behavior
GO_0003151	Biological process	outflow tract morphogenesis
GO_0055009	Biological process	atrial cardiac muscle tissue morphogenesis
GO_0060392	Biological process	negative regulation of SMAD protein signal transduction
GO_0001701	Biological process	in utero embryonic development
GO_0003272	Biological process	endocardial cushion formation
GO_0021510	Biological process	spinal cord development
GO_0010629	Biological process	negative regulation of gene expression
GO_0090193	Biological process	positive regulation of glomerulus development
GO_0001649	Biological process	osteoblast differentiation
GO_0061053	Biological process	somite development
GO_0060044	Biological process	negative regulation of cardiac muscle cell proliferation
GO_0060173	Biological process	limb development
GO_0010628	Biological process	positive regulation of gene expression
GO_0042733	Biological process	embryonic digit morphogenesis
GO_0060513	Biological process	prostatic bud formation
GO_0003149	Biological process	membranous septum morphogenesis
GO_0060302	Biological process	negative regulation of cytokine activity
GO_1990926	Biological process	short-term synaptic potentiation
GO_0003223	Biological process	ventricular compact myocardium morphogenesis
GO_0048570	Biological process	notochord morphogenesis
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0030514	Biological process	negative regulation of BMP signaling pathway
GO_0048712	Biological process	negative regulation of astrocyte differentiation
GO_0090090	Biological process	negative regulation of canonical Wnt signaling pathway
GO_0060291	Biological process	long-term synaptic potentiation
GO_0060676	Biological process	ureteric bud formation
GO_0008542	Biological process	visual learning
GO_0060272	Biological process	embryonic skeletal joint morphogenesis
GO_0009953	Biological process	dorsal/ventral pattern formation
GO_0042060	Biological process	wound healing
GO_0030509	Biological process	BMP signaling pathway
GO_0050679	Biological process	positive regulation of epithelial cell proliferation
GO_0021533	Biological process	cell differentiation in hindbrain
GO_0048168	Biological process	regulation of neuronal synaptic plasticity
GO_0001707	Biological process	mesoderm formation
GO_0048706	Biological process	embryonic skeletal system development
GO_0060425	Biological process	lung morphogenesis
GO_0099171	Biological process	presynaptic modulation of chemical synaptic transmission
GO_0045668	Biological process	negative regulation of osteoblast differentiation
GO_0001843	Biological process	neural tube closure
GO_0060412	Biological process	ventricular septum morphogenesis
GO_0038092	Biological process	nodal signaling pathway
GO_0090190	Biological process	positive regulation of branching involved in ureteric bud morphogenesis
GO_2001234	Biological process	negative regulation of apoptotic signaling pathway
GO_0001501	Biological process	skeletal system development
GO_0030336	Biological process	negative regulation of cell migration
GO_0001706	Biological process	endoderm formation
GO_0008045	Biological process	motor neuron axon guidance
GO_0040036	Biological process	regulation of fibroblast growth factor receptor signaling pathway
GO_0062044	Biological process	negative regulation of cardiac epithelial to mesenchymal transition
GO_0042474	Biological process	middle ear morphogenesis
GO_0021983	Biological process	pituitary gland development
GO_0048863	Biological process	stem cell differentiation
GO_0048318	Biological process	axial mesoderm development
GO_0061626	Biological process	pharyngeal arch artery morphogenesis
GO_0060325	Biological process	face morphogenesis
GO_0051216	Biological process	cartilage development
GO_0021999	Biological process	neural plate anterior/posterior regionalization
GO_0007399	Biological process	nervous system development
GO_0061037	Biological process	negative regulation of cartilage development
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0008543	Biological process	fibroblast growth factor receptor signaling pathway
GO_0035019	Biological process	somatic stem cell population maintenance
GO_0005615	Cellular component	extracellular space
GO_0098793	Cellular component	presynapse
GO_0005576	Cellular component	extracellular region
GO_0042803	Molecular function	protein homodimerization activity
GO_0019955	Molecular function	cytokine binding
GO_0005515	Molecular function	protein binding

Gene name	NOG
Protein name	Noggin
Synonyms
Description	FUNCTION: Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6 . .
Accessions	ENST00000332822.6 Q13253

NOG report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review