I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| fibroblast | 5 studies | 20% ± 1% | |
| smooth muscle cell | 5 studies | 34% ± 15% | |
| pericyte | 3 studies | 25% ± 8% | |
| endothelial cell | 3 studies | 28% ± 5% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| fibroblast | 5 studies | 20% ± 1% | |
| smooth muscle cell | 5 studies | 34% ± 15% | |
| pericyte | 3 studies | 25% ± 8% | |
| endothelial cell | 3 studies | 28% ± 5% |
Insufficient scRNA-seq data for expression of TBX18 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 99% | 1724.18 | 456 / 459 | 76% | 2.74 | 845 / 1118 |
| skin | 87% | 2335.32 | 1572 / 1809 | 66% | 3.45 | 312 / 472 |
| bladder | 86% | 1048.86 | 18 / 21 | 36% | 1.54 | 182 / 504 |
| esophagus | 55% | 454.45 | 797 / 1445 | 49% | 3.07 | 90 / 183 |
| blood vessel | 100% | 7077.11 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| ovary | 61% | 654.21 | 109 / 180 | 28% | 1.49 | 120 / 430 |
| adipose | 85% | 1823.60 | 1026 / 1204 | 0% | 0 | 0 / 0 |
| uterus | 32% | 291.07 | 55 / 170 | 42% | 4.50 | 194 / 459 |
| heart | 67% | 843.09 | 580 / 861 | 0% | 0 | 0 / 0 |
| thymus | 41% | 283.42 | 265 / 653 | 8% | 0.13 | 50 / 605 |
| pancreas | 0% | 0 | 0 / 328 | 42% | 1.57 | 75 / 178 |
| lung | 3% | 22.45 | 16 / 578 | 39% | 1.94 | 448 / 1155 |
| intestine | 4% | 28.75 | 42 / 966 | 26% | 1.12 | 139 / 527 |
| adrenal gland | 17% | 108.69 | 45 / 258 | 13% | 0.41 | 29 / 230 |
| tonsil | 0% | 0 | 0 / 0 | 29% | 0.91 | 13 / 45 |
| brain | 7% | 52.66 | 176 / 2642 | 20% | 0.49 | 140 / 705 |
| stomach | 3% | 19.80 | 11 / 359 | 22% | 1.25 | 62 / 286 |
| kidney | 1% | 9.89 | 1 / 89 | 21% | 0.61 | 187 / 901 |
| eye | 0% | 0 | 0 / 0 | 11% | 0.22 | 9 / 80 |
| prostate | 8% | 87.94 | 19 / 245 | 2% | 0.03 | 10 / 502 |
| liver | 0% | 0 | 0 / 226 | 8% | 0.34 | 32 / 406 |
| muscle | 8% | 54.77 | 62 / 803 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.04 | 1 / 29 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0098907 | Biological process | regulation of SA node cell action potential |
| GO_0001708 | Biological process | cell fate specification |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0090103 | Biological process | cochlea morphogenesis |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0060931 | Biological process | sinoatrial node cell development |
| GO_0090090 | Biological process | negative regulation of canonical Wnt signaling pathway |
| GO_0016331 | Biological process | morphogenesis of embryonic epithelium |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0051145 | Biological process | smooth muscle cell differentiation |
| GO_0001756 | Biological process | somitogenesis |
| GO_0072189 | Biological process | ureter development |
| GO_0060930 | Biological process | sinoatrial node cell fate commitment |
| GO_0003163 | Biological process | sinoatrial node development |
| GO_0021999 | Biological process | neural plate anterior/posterior regionalization |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0090571 | Cellular component | RNA polymerase II transcription repressor complex |
| GO_0000785 | Cellular component | chromatin |
| GO_0005634 | Cellular component | nucleus |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0001227 | Molecular function | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | TBX18 |
| Protein name | T-box transcription factor 18 T-box transcription factor TBX18 (T-box protein 18) TBX18 protein |
| Synonyms | |
| Description | FUNCTION: Acts as a transcriptional repressor involved in developmental processes of a variety of tissues and organs, including the heart and coronary vessels, the ureter and the vertebral column. Required for embryonic development of the sino atrial node (SAN) head area. . |
| Accessions | ENST00000369663.10 Q8IW86 ENST00000606784.5 U3KQH2 ENST00000606621.1 O95935 U3KQQ9 U3KQ31 ENST00000606325.5 |
