IGFBP4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0014070Biological processresponse to organic cyclic compound
GO_0010906Biological processregulation of glucose metabolic process
GO_0044342Biological processtype B pancreatic cell proliferation
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0001558Biological processregulation of cell growth
GO_0000165Biological processMAPK cascade
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0043567Biological processregulation of insulin-like growth factor receptor signaling pathway
GO_0043568Biological processpositive regulation of insulin-like growth factor receptor signaling pathway
GO_0005615Cellular componentextracellular space
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0005576Cellular componentextracellular region
GO_0031995Molecular functioninsulin-like growth factor II binding
GO_0005102Molecular functionsignaling receptor binding
GO_0005515Molecular functionprotein binding
GO_0031994Molecular functioninsulin-like growth factor I binding

IV. Literature review

[source]
Gene nameIGFBP4
Protein nameInsulin-like growth factor-binding protein 4 (IBP-4) (IGF-binding protein 4) (IGFBP-4)
SynonymsIBP4
DescriptionFUNCTION: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

AccessionsENST00000269593.5 [P22692-1]
P22692