TLE4 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	29 studies	27% ± 9%	Explore
endothelial cell	27 studies	27% ± 11%	Explore
macrophage	20 studies	32% ± 14%	Explore
smooth muscle cell	18 studies	19% ± 3%	Explore
classical monocyte	18 studies	27% ± 12%	Explore
non-classical monocyte	16 studies	35% ± 17%	Explore
fibroblast	16 studies	25% ± 7%	Explore
T cell	15 studies	23% ± 7%	Explore
monocyte	15 studies	29% ± 12%	Explore
oligodendrocyte	15 studies	50% ± 15%	Explore
astrocyte	15 studies	29% ± 13%	Explore
B cell	14 studies	25% ± 8%	Explore
oligodendrocyte precursor cell	14 studies	42% ± 17%	Explore
pericyte	14 studies	25% ± 7%	Explore
microglial cell	14 studies	32% ± 9%	Explore
glutamatergic neuron	13 studies	36% ± 18%	Explore
CD4-positive, alpha-beta T cell	13 studies	24% ± 7%	Explore
ciliated cell	13 studies	30% ± 16%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	24% ± 7%	Explore
CD8-positive, alpha-beta T cell	12 studies	24% ± 7%	Explore
gamma-delta T cell	11 studies	23% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	30% ± 12%	Explore
mature NK T cell	10 studies	26% ± 7%	Explore
epithelial cell	10 studies	32% ± 12%	Explore
endothelial cell of lymphatic vessel	9 studies	27% ± 9%	Explore
amacrine cell	8 studies	30% ± 11%	Explore
retinal rod cell	8 studies	35% ± 6%	Explore
myeloid cell	8 studies	30% ± 8%	Explore
mast cell	7 studies	26% ± 8%	Explore
leukocyte	7 studies	25% ± 7%	Explore
capillary endothelial cell	7 studies	20% ± 7%	Explore
myofibroblast cell	7 studies	27% ± 9%	Explore
connective tissue cell	7 studies	25% ± 4%	Explore
retinal ganglion cell	7 studies	37% ± 19%	Explore
basal cell	7 studies	31% ± 11%	Explore
mucosal invariant T cell	7 studies	23% ± 6%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	24% ± 4%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	6 studies	28% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	32% ± 11%	Explore
retina horizontal cell	6 studies	67% ± 8%	Explore
dendritic cell	6 studies	28% ± 14%	Explore
regulatory T cell	6 studies	20% ± 4%	Explore
type II pneumocyte	6 studies	18% ± 2%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	27% ± 16%	Explore
conventional dendritic cell	5 studies	29% ± 15%	Explore
neuron	5 studies	42% ± 15%	Explore
precursor B cell	5 studies	31% ± 6%	Explore
pro-B cell	5 studies	40% ± 15%	Explore
plasma cell	5 studies	26% ± 11%	Explore
club cell	5 studies	22% ± 5%	Explore
retinal cone cell	5 studies	29% ± 6%	Explore
lymphocyte	5 studies	33% ± 11%	Explore
Mueller cell	5 studies	25% ± 11%	Explore
goblet cell	5 studies	23% ± 9%	Explore
naive B cell	4 studies	19% ± 3%	Explore
podocyte	4 studies	32% ± 5%	Explore
abnormal cell	4 studies	24% ± 7%	Explore
retinal pigment epithelial cell	4 studies	39% ± 15%	Explore
mononuclear phagocyte	4 studies	32% ± 13%	Explore
ON-bipolar cell	4 studies	23% ± 3%	Explore
innate lymphoid cell	4 studies	23% ± 6%	Explore
GABAergic neuron	4 studies	38% ± 11%	Explore
brush cell	4 studies	53% ± 17%	Explore
myoepithelial cell	4 studies	34% ± 9%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	29% ± 11%	Explore
progenitor cell	3 studies	22% ± 4%	Explore
adipocyte	3 studies	24% ± 7%	Explore
GABAergic amacrine cell	3 studies	26% ± 4%	Explore
OFF-bipolar cell	3 studies	22% ± 4%	Explore
glycinergic amacrine cell	3 studies	28% ± 1%	Explore
CD4-positive helper T cell	3 studies	27% ± 4%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	33% ± 13%	Explore
muscle cell	3 studies	25% ± 5%	Explore
ependymal cell	3 studies	41% ± 16%	Explore
neutrophil	3 studies	25% ± 11%	Explore
alveolar macrophage	3 studies	31% ± 10%	Explore
T follicular helper cell	3 studies	26% ± 5%	Explore
T-helper 17 cell	3 studies	21% ± 6%	Explore
granule cell	3 studies	29% ± 4%	Explore
secretory cell	3 studies	21% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	18 studies	33% ± 15%	Explore
lung	12 studies	22% ± 5%	Explore
eye	10 studies	31% ± 6%	Explore
peripheral blood	8 studies	31% ± 15%	Explore
liver	4 studies	21% ± 2%	Explore
adipose	4 studies	19% ± 2%	Explore
heart	3 studies	16% ± 0%	Explore
intestine	3 studies	29% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	2819.51	2637 / 2642	100%	17.21	702 / 705
adrenal gland	100%	2160.32	258 / 258	97%	18.15	223 / 230
lung	100%	2230.17	578 / 578	95%	9.75	1098 / 1155
esophagus	100%	1816.32	1444 / 1445	95%	14.72	174 / 183
bladder	100%	2626.86	21 / 21	92%	7.50	463 / 504
stomach	100%	1581.30	358 / 359	91%	7.04	261 / 286
intestine	100%	1758.35	966 / 966	91%	6.35	477 / 527
uterus	100%	1982.75	170 / 170	90%	12.21	413 / 459
kidney	98%	959.22	87 / 89	91%	5.94	819 / 901
prostate	96%	1080.66	236 / 245	91%	6.21	457 / 502
breast	100%	1613.80	458 / 459	87%	6.08	972 / 1118
thymus	100%	1748.26	651 / 653	81%	7.70	492 / 605
pancreas	84%	571.98	274 / 328	97%	9.13	173 / 178
ovary	100%	3640.94	180 / 180	73%	6.21	312 / 430
skin	100%	2232.82	1805 / 1809	73%	9.13	343 / 472
lymph node	0%	0	0 / 0	100%	16.23	29 / 29
muscle	100%	2059.95	803 / 803	0%	0	0 / 0
spleen	100%	2845.95	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	18.14	45 / 45
blood vessel	100%	1808.26	1333 / 1335	0%	0	0 / 0
adipose	100%	1471.37	1200 / 1204	0%	0	0 / 0
peripheral blood	99%	2811.75	919 / 929	0%	0	0 / 0
heart	90%	716.49	774 / 861	0%	0	0 / 0
liver	27%	147.91	61 / 226	45%	2.00	184 / 406
eye	0%	0	0 / 0	49%	1.83	39 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_1990830	Biological process	cellular response to leukemia inhibitory factor
GO_0016055	Biological process	Wnt signaling pathway
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0008150	Biological process	biological_process
GO_0090090	Biological process	negative regulation of canonical Wnt signaling pathway
GO_1990907	Cellular component	beta-catenin-TCF complex
GO_0005654	Cellular component	nucleoplasm
GO_0005667	Cellular component	transcription regulator complex
GO_0005634	Cellular component	nucleus
GO_0140297	Molecular function	DNA-binding transcription factor binding
GO_0003714	Molecular function	transcription corepressor activity
GO_0005515	Molecular function	protein binding
GO_0003682	Molecular function	chromatin binding

IV. Literature review

[source]

Gene name	TLE4
Protein name	TLE family member 4, transcriptional corepressor TLE family member 4, transcriptional corepressor (Transducin-like enhancer of split 4 (E(Sp1) homolog, Drosophila), isoform CRA_d) Transducin-like enhancer protein 4 (Grg-4) (Groucho-related protein 4)
Synonyms	KIAA1261 hCG_1984553 GRG4
Description	FUNCTION: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity). Involved in transcriptional repression of GNRHR and enhances MSX1-mediated transcriptional repression of CGA/alpha-GSU (By similarity). .
Accessions	H7C4E4 ENST00000435650.5 ENST00000470872.5 E7EQH3 ENST00000376537.8 [Q04727-3] ENST00000376544.7 [Q04727-2] Q5JSZ1 ENST00000461758.6 ENST00000462803.5 Q04727 A0A994J7T6 ENST00000490347.5 Q5JSY8 H7C4W5 Q5JSY7 ENST00000706431.1 ENST00000428713.5 ENST00000414465.5 ENST00000265284.10 [Q04727-4] H7C4P7 ENST00000417836.1 ENST00000467142.5 F8WAY5 ENST00000425506.5 ENST00000496114.5 ENST00000376552.8 [Q04727-1] Q5JSZ2 H0Y5S0 A0A0A0MT79

TLE4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review