Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| oligodendrocyte precursor cell | 12 studies | 45% ± 20% | |
| epithelial cell | 5 studies | 27% ± 8% | |
| intestinal crypt stem cell | 3 studies | 34% ± 6% | |
| basal cell | 3 studies | 30% ± 10% | |
| transit amplifying cell | 3 studies | 35% ± 15% |
Insufficient scRNA-seq data for expression of FERMT1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| stomach | 70% | 494.25 | 252 / 359 | 97% | 151.79 | 278 / 286 |
| intestine | 50% | 1072.58 | 487 / 966 | 98% | 161.35 | 515 / 527 |
| bladder | 57% | 945.43 | 12 / 21 | 90% | 90.75 | 456 / 504 |
| esophagus | 41% | 1225.74 | 586 / 1445 | 97% | 86.19 | 178 / 183 |
| pancreas | 43% | 143.87 | 141 / 328 | 90% | 46.40 | 161 / 178 |
| brain | 60% | 251.81 | 1596 / 2642 | 71% | 52.15 | 498 / 705 |
| prostate | 90% | 745.36 | 220 / 245 | 38% | 6.87 | 189 / 502 |
| uterus | 54% | 251.52 | 92 / 170 | 71% | 33.68 | 324 / 459 |
| adrenal gland | 100% | 4014.89 | 258 / 258 | 11% | 2.75 | 25 / 230 |
| ureter | 0% | 0 | 0 / 0 | 100% | 12.33 | 1 / 1 |
| skin | 95% | 2169.09 | 1727 / 1809 | 4% | 1.35 | 18 / 472 |
| ovary | 87% | 454.89 | 157 / 180 | 11% | 2.01 | 46 / 430 |
| tonsil | 0% | 0 | 0 / 0 | 96% | 54.42 | 43 / 45 |
| lung | 13% | 42.77 | 73 / 578 | 81% | 46.11 | 932 / 1155 |
| thymus | 77% | 337.17 | 502 / 653 | 11% | 3.46 | 67 / 605 |
| kidney | 38% | 179.49 | 34 / 89 | 6% | 1.29 | 57 / 901 |
| breast | 31% | 141.30 | 144 / 459 | 10% | 2.84 | 117 / 1118 |
| liver | 1% | 3.55 | 3 / 226 | 12% | 2.51 | 48 / 406 |
| heart | 12% | 39.50 | 101 / 861 | 0% | 0 | 0 / 0 |
| adipose | 5% | 17.30 | 60 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 4% | 13.72 | 51 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 2% | 4.24 | 4 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0.94 | 2 / 929 | 0% | 0 | 0 / 0 |
| muscle | 0% | 0.33 | 1 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0030511 | Biological process | positive regulation of transforming growth factor beta receptor signaling pathway |
| GO_0071636 | Biological process | positive regulation of transforming growth factor beta production |
| GO_0033630 | Biological process | positive regulation of cell adhesion mediated by integrin |
| GO_0090162 | Biological process | establishment of epithelial cell polarity |
| GO_0010629 | Biological process | negative regulation of gene expression |
| GO_0007160 | Biological process | cell-matrix adhesion |
| GO_0001954 | Biological process | positive regulation of cell-matrix adhesion |
| GO_0042308 | Biological process | negative regulation of protein import into nucleus |
| GO_0051546 | Biological process | keratinocyte migration |
| GO_0007155 | Biological process | cell adhesion |
| GO_0090090 | Biological process | negative regulation of canonical Wnt signaling pathway |
| GO_1903691 | Biological process | positive regulation of wound healing, spreading of epidermal cells |
| GO_2000647 | Biological process | negative regulation of stem cell proliferation |
| GO_0071711 | Biological process | basement membrane organization |
| GO_0007229 | Biological process | integrin-mediated signaling pathway |
| GO_0033625 | Biological process | positive regulation of integrin activation |
| GO_0043616 | Biological process | keratinocyte proliferation |
| GO_0051886 | Biological process | negative regulation of timing of anagen |
| GO_0032587 | Cellular component | ruffle membrane |
| GO_0005856 | Cellular component | cytoskeleton |
| GO_0005925 | Cellular component | focal adhesion |
| GO_0005829 | Cellular component | cytosol |
| GO_0071944 | Cellular component | cell periphery |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0030054 | Cellular component | cell junction |
| GO_0051015 | Molecular function | actin filament binding |
| GO_0005178 | Molecular function | integrin binding |
| Gene name | FERMT1 |
| Protein name | FERMT1 protein FERM domain containing kindlin 1 Fermitin family homolog 1 (Kindlerin) (Kindlin syndrome protein) (Kindlin-1) (Unc-112-related protein 1) |
| Synonyms | KIND1 C20orf42 URP1 |
| Description | FUNCTION: Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites. May mediate TGF-beta 1 signaling in tumor progression. . |
| Accessions | Q9BQL6 ENST00000217289.9 [Q9BQL6-1] G3V1L6 ENST00000536936.1 ENST00000699098.1 Q49AC8 A0A8V8TN73 ENST00000699095.1 [Q9BQL6-1] |
