PFDN5 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	50 studies	82% ± 20%	Explore
macrophage	48 studies	72% ± 27%	Explore
natural killer cell	44 studies	76% ± 20%	Explore
endothelial cell	42 studies	65% ± 24%	Explore
T cell	41 studies	69% ± 26%	Explore
fibroblast	39 studies	76% ± 23%	Explore
CD8-positive, alpha-beta T cell	39 studies	77% ± 21%	Explore
CD4-positive, alpha-beta T cell	35 studies	82% ± 19%	Explore
pericyte	33 studies	74% ± 25%	Explore
conventional dendritic cell	30 studies	91% ± 12%	Explore
dendritic cell	29 studies	77% ± 25%	Explore
classical monocyte	29 studies	88% ± 16%	Explore
monocyte	27 studies	77% ± 24%	Explore
plasmacytoid dendritic cell	27 studies	87% ± 9%	Explore
regulatory T cell	27 studies	87% ± 12%	Explore
smooth muscle cell	26 studies	79% ± 20%	Explore
non-classical monocyte	26 studies	91% ± 14%	Explore
plasma cell	25 studies	71% ± 19%	Explore
mast cell	24 studies	73% ± 22%	Explore
epithelial cell	24 studies	78% ± 20%	Explore
endothelial cell of lymphatic vessel	23 studies	77% ± 21%	Explore
gamma-delta T cell	21 studies	79% ± 22%	Explore
mature NK T cell	21 studies	78% ± 17%	Explore
memory B cell	21 studies	89% ± 17%	Explore
basal cell	21 studies	81% ± 19%	Explore
naive B cell	19 studies	90% ± 8%	Explore
ciliated cell	18 studies	82% ± 17%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	18 studies	87% ± 14%	Explore
connective tissue cell	18 studies	83% ± 13%	Explore
mucosal invariant T cell	16 studies	84% ± 15%	Explore
myeloid cell	16 studies	70% ± 31%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	75% ± 23%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	15 studies	89% ± 17%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	79% ± 13%	Explore
capillary endothelial cell	15 studies	53% ± 21%	Explore
myofibroblast cell	15 studies	78% ± 22%	Explore
endothelial cell of artery	14 studies	64% ± 21%	Explore
CD4-positive, alpha-beta memory T cell	13 studies	79% ± 20%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	80% ± 21%	Explore
neutrophil	13 studies	55% ± 26%	Explore
vein endothelial cell	13 studies	69% ± 23%	Explore
endothelial cell of vascular tree	13 studies	73% ± 26%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	78% ± 21%	Explore
innate lymphoid cell	12 studies	83% ± 10%	Explore
plasmablast	12 studies	76% ± 15%	Explore
secretory cell	12 studies	83% ± 16%	Explore
leukocyte	11 studies	76% ± 22%	Explore
goblet cell	11 studies	64% ± 23%	Explore
type I pneumocyte	10 studies	56% ± 23%	Explore
erythrocyte	10 studies	63% ± 24%	Explore
T follicular helper cell	10 studies	90% ± 7%	Explore
progenitor cell	10 studies	82% ± 17%	Explore
abnormal cell	10 studies	75% ± 26%	Explore
mesothelial cell	10 studies	83% ± 20%	Explore
type II pneumocyte	9 studies	72% ± 26%	Explore
club cell	9 studies	78% ± 18%	Explore
astrocyte	9 studies	34% ± 16%	Explore
microglial cell	9 studies	57% ± 30%	Explore
alveolar macrophage	8 studies	68% ± 32%	Explore
platelet	8 studies	47% ± 26%	Explore
neuron	8 studies	60% ± 26%	Explore
IgG plasma cell	8 studies	64% ± 16%	Explore
ionocyte	7 studies	70% ± 15%	Explore
respiratory goblet cell	7 studies	69% ± 17%	Explore
effector CD4-positive, alpha-beta T cell	7 studies	80% ± 26%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	88% ± 6%	Explore
mononuclear phagocyte	7 studies	80% ± 23%	Explore
epithelial cell of proximal tubule	7 studies	75% ± 17%	Explore
enterocyte	7 studies	63% ± 21%	Explore
IgA plasma cell	7 studies	64% ± 22%	Explore
retinal rod cell	7 studies	53% ± 25%	Explore
hematopoietic stem cell	7 studies	96% ± 4%	Explore
brush cell	7 studies	60% ± 24%	Explore
hematopoietic precursor cell	6 studies	74% ± 29%	Explore
kidney loop of Henle epithelial cell	6 studies	72% ± 11%	Explore
renal alpha-intercalated cell	6 studies	92% ± 3%	Explore
enteroendocrine cell	6 studies	78% ± 24%	Explore
erythroblast	6 studies	65% ± 22%	Explore
intestinal crypt stem cell	6 studies	65% ± 32%	Explore
transit amplifying cell	6 studies	64% ± 25%	Explore
retinal cone cell	6 studies	62% ± 30%	Explore
precursor B cell	6 studies	83% ± 9%	Explore
immature B cell	6 studies	87% ± 13%	Explore
intermediate monocyte	6 studies	89% ± 13%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	91% ± 7%	Explore
CD4-positive helper T cell	5 studies	83% ± 11%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	87% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	83% ± 6%	Explore
exhausted T cell	5 studies	90% ± 4%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	88% ± 8%	Explore
glutamatergic neuron	5 studies	29% ± 14%	Explore
amacrine cell	5 studies	51% ± 21%	Explore
retinal ganglion cell	5 studies	65% ± 27%	Explore
lymphocyte	5 studies	76% ± 29%	Explore
T-helper 17 cell	5 studies	90% ± 6%	Explore
group 3 innate lymphoid cell	5 studies	89% ± 5%	Explore
mucus secreting cell	5 studies	67% ± 32%	Explore
double negative thymocyte	5 studies	92% ± 4%	Explore
granulocyte	5 studies	86% ± 13%	Explore
melanocyte	5 studies	62% ± 28%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	74% ± 24%	Explore
deuterosomal cell	4 studies	72% ± 17%	Explore
duct epithelial cell	4 studies	86% ± 4%	Explore
squamous epithelial cell	4 studies	40% ± 24%	Explore
pancreatic A cell	4 studies	85% ± 10%	Explore
type B pancreatic cell	4 studies	87% ± 9%	Explore
glomerular endothelial cell	4 studies	59% ± 18%	Explore
podocyte	4 studies	81% ± 9%	Explore
oligodendrocyte	4 studies	28% ± 8%	Explore
OFF-bipolar cell	4 studies	54% ± 27%	Explore
ON-bipolar cell	4 studies	53% ± 27%	Explore
pro-B cell	4 studies	81% ± 4%	Explore
retina horizontal cell	4 studies	50% ± 22%	Explore
retinal pigment epithelial cell	4 studies	53% ± 29%	Explore
adventitial cell	4 studies	72% ± 11%	Explore
Mueller cell	4 studies	51% ± 19%	Explore
inflammatory macrophage	4 studies	75% ± 13%	Explore
acinar cell	4 studies	72% ± 10%	Explore
muscle cell	4 studies	51% ± 20%	Explore
germinal center B cell	4 studies	73% ± 21%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	91% ± 8%	Explore
luminal cell of prostate epithelium	4 studies	72% ± 30%	Explore
oligodendrocyte precursor cell	4 studies	44% ± 27%	Explore
glial cell	4 studies	55% ± 27%	Explore
hepatocyte	4 studies	56% ± 27%	Explore
keratinocyte	4 studies	70% ± 31%	Explore
interneuron	4 studies	43% ± 27%	Explore
T-helper 1 cell	4 studies	93% ± 4%	Explore
hillock cell	3 studies	52% ± 26%	Explore
precursor cell	3 studies	87% ± 6%	Explore
pancreatic D cell	3 studies	82% ± 14%	Explore
monocyte-derived dendritic cell	3 studies	96% ± 3%	Explore
kidney connecting tubule epithelial cell	3 studies	85% ± 9%	Explore
renal beta-intercalated cell	3 studies	91% ± 6%	Explore
neural crest cell	3 studies	91% ± 4%	Explore
paneth cell	3 studies	74% ± 17%	Explore
retinal bipolar neuron	3 studies	65% ± 24%	Explore
GABAergic amacrine cell	3 studies	30% ± 11%	Explore
glycinergic amacrine cell	3 studies	29% ± 11%	Explore
renal principal cell	3 studies	81% ± 2%	Explore
thymocyte	3 studies	89% ± 5%	Explore
extravillous trophoblast	3 studies	98% ± 1%	Explore
placental villous trophoblast	3 studies	96% ± 3%	Explore
megakaryocyte	3 studies	59% ± 18%	Explore
neuroendocrine cell	3 studies	80% ± 18%	Explore
serous secreting cell	3 studies	82% ± 12%	Explore
tissue-resident macrophage	3 studies	68% ± 28%	Explore
follicular B cell	3 studies	87% ± 7%	Explore
intraepithelial lymphocyte	3 studies	83% ± 5%	Explore
rod bipolar cell	3 studies	53% ± 19%	Explore
endothelial cell of sinusoid	3 studies	49% ± 24%	Explore
myoepithelial cell	3 studies	92% ± 1%	Explore
IgM plasma cell	3 studies	71% ± 13%	Explore
pancreatic ductal cell	3 studies	75% ± 12%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	95% ± 4%	Explore
GABAergic neuron	3 studies	28% ± 9%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	95% ± 3%	Explore
double-positive, alpha-beta thymocyte	3 studies	91% ± 5%	Explore
progenitor cell of mammary luminal epithelium	3 studies	97% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	21 studies	85% ± 16%	Explore
lung	19 studies	75% ± 18%	Explore
intestine	13 studies	70% ± 23%	Explore
brain	12 studies	35% ± 22%	Explore
eye	10 studies	52% ± 23%	Explore
kidney	9 studies	75% ± 18%	Explore
liver	7 studies	61% ± 26%	Explore
bone marrow	6 studies	69% ± 25%	Explore
lymph node	6 studies	90% ± 5%	Explore
pancreas	5 studies	77% ± 17%	Explore
placenta	5 studies	72% ± 32%	Explore
uterus	5 studies	84% ± 17%	Explore
adipose	4 studies	40% ± 28%	Explore
prostate	4 studies	78% ± 21%	Explore
breast	4 studies	88% ± 6%	Explore
heart	3 studies	41% ± 15%	Explore
adrenal gland	3 studies	73% ± 16%	Explore
esophagus	3 studies	73% ± 19%	Explore
skin	3 studies	76% ± 19%	Explore
thymus	3 studies	83% ± 15%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	11511.81	2640 / 2642	86%	2.19	607 / 705
pancreas	100%	8623.42	328 / 328	86%	1.89	153 / 178
uterus	100%	16023.94	170 / 170	85%	2.01	389 / 459
bladder	100%	13729.71	21 / 21	78%	1.88	392 / 504
thymus	100%	15405.85	653 / 653	76%	1.55	460 / 605
lung	100%	12234.88	578 / 578	75%	1.91	870 / 1155
intestine	100%	12538.02	966 / 966	73%	1.59	386 / 527
breast	100%	16125.53	459 / 459	72%	1.49	804 / 1118
ovary	100%	20300.60	180 / 180	68%	1.21	291 / 430
skin	100%	13255.40	1809 / 1809	67%	1.47	315 / 472
esophagus	100%	11881.11	1445 / 1445	67%	1.09	122 / 183
prostate	100%	15233.83	245 / 245	60%	1.02	301 / 502
adrenal gland	100%	13615.92	258 / 258	59%	1.05	135 / 230
kidney	100%	13057.18	89 / 89	58%	1.49	520 / 901
stomach	100%	10140.43	359 / 359	55%	1.12	158 / 286
liver	100%	5029.87	226 / 226	28%	0.50	112 / 406
adipose	100%	14915.70	1204 / 1204	0%	0	0 / 0
blood vessel	100%	14260.31	1335 / 1335	0%	0	0 / 0
spleen	100%	15669.37	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	1.85	1 / 1
muscle	99%	8875.47	798 / 803	0%	0	0 / 0
heart	99%	8229.80	853 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	86%	2.45	25 / 29
peripheral blood	85%	6098.17	790 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	67%	1.37	30 / 45
eye	0%	0	0 / 0	39%	0.82	31 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_1990114	Biological process	RNA polymerase II core complex assembly
GO_0061077	Biological process	chaperone-mediated protein folding
GO_0060041	Biological process	retina development in camera-type eye
GO_1990115	Biological process	RNA polymerase III assembly
GO_0090090	Biological process	negative regulation of canonical Wnt signaling pathway
GO_0006457	Biological process	protein folding
GO_1990113	Biological process	RNA polymerase I assembly
GO_1905907	Biological process	negative regulation of amyloid fibril formation
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0016272	Cellular component	prefoldin complex
GO_0045111	Cellular component	intermediate filament cytoskeleton
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0001540	Molecular function	amyloid-beta binding
GO_0003714	Molecular function	transcription corepressor activity
GO_0051082	Molecular function	unfolded protein binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PFDN5
Protein name	Prefoldin subunit 5 (Myc modulator 1) (c-Myc-binding protein Mm-1) Prefoldin subunit 5
Synonyms	PFD5 MM1 hCG_23361
Description	FUNCTION: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC. .
Accessions	ENST00000334478.9 [Q99471-1] ENST00000552742.6 ENST00000708930.1 [Q99471-3] ENST00000708936.1 [Q99471-2] F8VNW6 ENST00000551018.5 [Q99471-1] Q99471 ENST00000550846.5 H3BPF6 A0A7I2V5H9 ENST00000708937.1 [Q99471-1] ENST00000676468.1 ENST00000628881.2 H3BMQ1 ENST00000549759.2 ENST00000243040.10 [Q99471-2] ENST00000550880.5 F8VQZ2 ENST00000708922.1 [Q99471-1] ENST00000547130.6 A0A0D9SFR8 ENST00000351500.7 [Q99471-3]

PFDN5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review