SHISA6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016055Biological processWnt signaling pathway
GO_0007283Biological processspermatogenesis
GO_1904717Biological processregulation of AMPA glutamate receptor clustering
GO_0098976Biological processexcitatory chemical synaptic transmission
GO_0048172Biological processregulation of short-term neuronal synaptic plasticity
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_2000311Biological processregulation of AMPA receptor activity
GO_0098970Biological processpostsynaptic neurotransmitter receptor diffusion trapping
GO_0098839Cellular componentpostsynaptic density membrane
GO_0098985Cellular componentasymmetric, glutamatergic, excitatory synapse
GO_0032281Cellular componentAMPA glutamate receptor complex
GO_0014069Cellular componentpostsynaptic density
GO_0032591Cellular componentdendritic spine membrane
GO_0045211Cellular componentpostsynaptic membrane
GO_0035255Molecular functionionotropic glutamate receptor binding
GO_0030165Molecular functionPDZ domain binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSHISA6
Protein nameShisa family member 6
Protein shisa-6
Synonyms
DescriptionFUNCTION: Involved in maintenance of high-frequency synaptic transmission at hippocampal CA3-CA1 synapses. Regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression. May play a role in self-renewal and differentiation of spermatogonial stem cells by inhibiting canonical Wnt signaling pathway. .

AccessionsENST00000343478.7
ENST00000432116.7 [Q6ZSJ9-2]
ENST00000441885.8 [Q6ZSJ9-3]
V9GZ25
ENST00000409168.7 [Q6ZSJ9-1]
Q6ZSJ9