Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| oligodendrocyte precursor cell | 12 studies | 33% ± 13% | |
| GABAergic neuron | 11 studies | 37% ± 22% | |
| astrocyte | 11 studies | 34% ± 15% | |
| glutamatergic neuron | 6 studies | 38% ± 14% | |
| interneuron | 6 studies | 42% ± 22% | |
| endothelial cell | 5 studies | 29% ± 17% | |
| adipocyte | 4 studies | 25% ± 6% | |
| ciliated cell | 4 studies | 35% ± 9% | |
| pericyte | 4 studies | 23% ± 4% | |
| GABAergic interneuron | 3 studies | 35% ± 15% | |
| glycinergic amacrine cell | 3 studies | 39% ± 7% | |
| neuron | 3 studies | 40% ± 11% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 10 studies | 30% ± 16% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 91% | 710.93 | 223 / 245 | 96% | 7.17 | 483 / 502 |
| brain | 99% | 2102.46 | 2621 / 2642 | 84% | 14.93 | 590 / 705 |
| breast | 73% | 267.50 | 337 / 459 | 44% | 1.20 | 491 / 1118 |
| stomach | 59% | 202.80 | 212 / 359 | 27% | 1.42 | 77 / 286 |
| uterus | 68% | 933.94 | 116 / 170 | 12% | 0.29 | 55 / 459 |
| bladder | 67% | 234.24 | 14 / 21 | 9% | 0.29 | 45 / 504 |
| adipose | 76% | 262.70 | 910 / 1204 | 0% | 0 | 0 / 0 |
| esophagus | 51% | 193.57 | 732 / 1445 | 22% | 0.67 | 40 / 183 |
| thymus | 14% | 40.04 | 92 / 653 | 50% | 4.78 | 303 / 605 |
| intestine | 29% | 96.35 | 277 / 966 | 21% | 1.15 | 110 / 527 |
| pancreas | 2% | 6.02 | 8 / 328 | 46% | 0.90 | 81 / 178 |
| kidney | 28% | 97.62 | 25 / 89 | 19% | 0.56 | 173 / 901 |
| adrenal gland | 40% | 139.79 | 104 / 258 | 6% | 0.59 | 14 / 230 |
| skin | 24% | 78.00 | 442 / 1809 | 1% | 0.05 | 3 / 472 |
| ovary | 18% | 76.09 | 32 / 180 | 2% | 0.07 | 7 / 430 |
| muscle | 18% | 43.99 | 148 / 803 | 0% | 0 | 0 / 0 |
| lung | 1% | 2.01 | 5 / 578 | 13% | 0.42 | 154 / 1155 |
| heart | 9% | 17.47 | 74 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 6% | 22.56 | 86 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.02 | 1 / 80 |
| spleen | 1% | 2.02 | 2 / 241 | 0% | 0 | 0 / 0 |
| liver | 0% | 0 | 0 / 226 | 1% | 0.01 | 3 / 406 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0016055 | Biological process | Wnt signaling pathway |
| GO_0007283 | Biological process | spermatogenesis |
| GO_1904717 | Biological process | regulation of AMPA glutamate receptor clustering |
| GO_0098976 | Biological process | excitatory chemical synaptic transmission |
| GO_0048172 | Biological process | regulation of short-term neuronal synaptic plasticity |
| GO_0090090 | Biological process | negative regulation of canonical Wnt signaling pathway |
| GO_2000311 | Biological process | regulation of AMPA receptor activity |
| GO_0098970 | Biological process | postsynaptic neurotransmitter receptor diffusion trapping |
| GO_0098839 | Cellular component | postsynaptic density membrane |
| GO_0098985 | Cellular component | asymmetric, glutamatergic, excitatory synapse |
| GO_0032281 | Cellular component | AMPA glutamate receptor complex |
| GO_0014069 | Cellular component | postsynaptic density |
| GO_0032591 | Cellular component | dendritic spine membrane |
| GO_0045211 | Cellular component | postsynaptic membrane |
| GO_0035255 | Molecular function | ionotropic glutamate receptor binding |
| GO_0030165 | Molecular function | PDZ domain binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | SHISA6 |
| Protein name | Shisa family member 6 Protein shisa-6 |
| Synonyms | |
| Description | FUNCTION: Involved in maintenance of high-frequency synaptic transmission at hippocampal CA3-CA1 synapses. Regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression. May play a role in self-renewal and differentiation of spermatogonial stem cells by inhibiting canonical Wnt signaling pathway. . |
| Accessions | ENST00000343478.7 ENST00000432116.7 [Q6ZSJ9-2] ENST00000441885.8 [Q6ZSJ9-3] V9GZ25 ENST00000409168.7 [Q6ZSJ9-1] Q6ZSJ9 |