DRAXIN report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DRAXIN at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DRAXIN at tissue level.

III. Associated gene sets

GO_0021516Biological processdorsal spinal cord development
GO_0030517Biological processnegative regulation of axon extension
GO_0016055Biological processWnt signaling pathway
GO_0021960Biological processanterior commissure morphogenesis
GO_0110088Biological processhippocampal neuron apoptotic process
GO_0110091Biological processnegative regulation of hippocampal neuron apoptotic process
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0021528Biological processcommissural neuron differentiation in spinal cord
GO_0007411Biological processaxon guidance
GO_0030900Biological processforebrain development
GO_0005576Cellular componentextracellular region
GO_0005515Molecular functionprotein binding
GO_0060090Molecular functionmolecular adaptor activity

IV. Literature review

[source]
Gene nameDRAXIN
Protein nameDraxin (Dorsal inhibitory axon guidance protein) (Dorsal repulsive axon guidance protein) (Neucrin)
SynonymsPSEC0258
C1orf187
UNQ3119/PRO10268
DescriptionFUNCTION: Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. .

AccessionsENST00000294485.6
Q8NBI3