SIAH2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043154Biological processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0016567Biological processprotein ubiquitination
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0042752Biological processregulation of circadian rhythm
GO_0031396Biological processregulation of protein ubiquitination
GO_0060070Biological processcanonical Wnt signaling pathway
GO_1990000Biological processamyloid fibril formation
GO_0043066Biological processnegative regulation of apoptotic process
GO_0007264Biological processsmall GTPase-mediated signal transduction
GO_2001237Biological processnegative regulation of extrinsic apoptotic signaling pathway
GO_0006915Biological processapoptotic process
GO_0048511Biological processrhythmic process
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0005769Cellular componentearly endosome
GO_0005654Cellular componentnucleoplasm
GO_0043025Cellular componentneuronal cell body
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0003714Molecular functiontranscription corepressor activity
GO_0008270Molecular functionzinc ion binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding
GO_0031624Molecular functionubiquitin conjugating enzyme binding

IV. Literature review

[source]
Gene nameSIAH2
Protein nameE3 ubiquitin-protein ligase SIAH2 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH2) (Seven in absentia homolog 2) (Siah-2) (hSiah2)
Siah E3 ubiquitin protein ligase 2
Synonyms
DescriptionFUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins . E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates . Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes . Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (GPS2, POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP) . Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia . It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes . Has some overlapping function with SIAH1 . Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 does not . Promotes monoubiquitination of SNCA . Regulates cellular clock function via ubiquitination of the circadian transcriptional repressors NR1D1 and NR1D2 leading to their proteasomal degradation . Plays an important role in mediating the rhythmic degradation/clearance of NR1D1 and NR1D2 contributing to their circadian profile of protein abundance . Mediates ubiquitination and degradation of EGLN2 and EGLN3 in response to the unfolded protein response (UPR), leading to their degradation and subsequent stabilization of ATF4 (By similarity). Also part of the Wnt signaling pathway in which it mediates the Wnt-induced ubiquitin-mediated proteasomal degradation of AXIN1. .

AccessionsENST00000482706.1
ENST00000312960.4
O43255
C9J9D7