INVS report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1904108Biological processprotein localization to ciliary inversin compartment
GO_0016055Biological processWnt signaling pathway
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0097543Cellular componentciliary inversin compartment
GO_0005874Cellular componentmicrotubule
GO_0005819Cellular componentspindle
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005516Molecular functioncalmodulin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameINVS
Protein nameInversin (Inversion of embryo turning homolog) (Nephrocystin-2)
INVS protein
SynonymsINV
NPHP2
DescriptionFUNCTION: Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). .

AccessionsQ9Y283
ENST00000262457.7 [Q9Y283-1]
Q2M1I4
ENST00000262456.6 [Q9Y283-2]
ENST00000374921.3 [Q9Y283-3]