Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 19 studies | 30% ± 11% | |
oligodendrocyte | 15 studies | 38% ± 15% | |
astrocyte | 15 studies | 37% ± 19% | |
microglial cell | 12 studies | 32% ± 11% | |
oligodendrocyte precursor cell | 11 studies | 37% ± 15% | |
fibroblast | 11 studies | 31% ± 10% | |
glutamatergic neuron | 10 studies | 46% ± 26% | |
GABAergic neuron | 9 studies | 44% ± 26% | |
macrophage | 9 studies | 30% ± 12% | |
adipocyte | 9 studies | 34% ± 8% | |
pericyte | 8 studies | 26% ± 10% | |
neuron | 6 studies | 39% ± 20% | |
interneuron | 6 studies | 45% ± 26% | |
endothelial cell of lymphatic vessel | 6 studies | 31% ± 8% | |
smooth muscle cell | 6 studies | 30% ± 7% | |
type I pneumocyte | 5 studies | 27% ± 6% | |
type II pneumocyte | 5 studies | 24% ± 7% | |
granule cell | 4 studies | 28% ± 8% | |
cardiac muscle cell | 4 studies | 33% ± 5% | |
retina horizontal cell | 4 studies | 23% ± 6% | |
retinal cone cell | 4 studies | 24% ± 8% | |
retinal rod cell | 4 studies | 25% ± 4% | |
myeloid cell | 4 studies | 25% ± 7% | |
club cell | 4 studies | 23% ± 7% | |
GABAergic interneuron | 3 studies | 27% ± 5% | |
mast cell | 3 studies | 21% ± 5% | |
mesothelial cell | 3 studies | 29% ± 10% | |
Mueller cell | 3 studies | 28% ± 4% | |
amacrine cell | 3 studies | 21% ± 5% | |
glycinergic amacrine cell | 3 studies | 18% ± 2% | |
endothelial cell of vascular tree | 3 studies | 26% ± 11% | |
hepatocyte | 3 studies | 43% ± 16% | |
connective tissue cell | 3 studies | 23% ± 6% | |
ependymal cell | 3 studies | 37% ± 14% | |
T cell | 3 studies | 21% ± 1% | |
alveolar macrophage | 3 studies | 30% ± 6% | |
ciliated cell | 3 studies | 22% ± 7% | |
monocyte | 3 studies | 23% ± 5% | |
lymphocyte | 3 studies | 24% ± 5% | |
basal cell | 3 studies | 33% ± 16% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 816.47 | 1445 / 1445 | 100% | 9.89 | 183 / 183 |
prostate | 100% | 1181.95 | 245 / 245 | 100% | 8.18 | 502 / 502 |
stomach | 100% | 638.84 | 359 / 359 | 100% | 7.48 | 285 / 286 |
breast | 100% | 954.67 | 459 / 459 | 99% | 7.06 | 1110 / 1118 |
lung | 100% | 971.80 | 577 / 578 | 99% | 6.84 | 1145 / 1155 |
intestine | 100% | 910.78 | 966 / 966 | 99% | 6.72 | 521 / 527 |
bladder | 100% | 968.62 | 21 / 21 | 98% | 6.28 | 494 / 504 |
uterus | 100% | 1332.08 | 170 / 170 | 97% | 6.29 | 447 / 459 |
thymus | 100% | 1158.47 | 653 / 653 | 97% | 6.08 | 589 / 605 |
pancreas | 99% | 471.77 | 324 / 328 | 98% | 5.73 | 175 / 178 |
kidney | 100% | 931.16 | 89 / 89 | 96% | 7.61 | 869 / 901 |
brain | 98% | 501.86 | 2585 / 2642 | 99% | 6.67 | 695 / 705 |
skin | 100% | 823.28 | 1804 / 1809 | 96% | 6.98 | 455 / 472 |
adrenal gland | 100% | 1044.26 | 258 / 258 | 95% | 6.40 | 218 / 230 |
ovary | 100% | 1542.98 | 180 / 180 | 95% | 5.12 | 407 / 430 |
liver | 100% | 775.16 | 226 / 226 | 92% | 4.28 | 372 / 406 |
adipose | 100% | 1110.94 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 970.76 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 8.31 | 29 / 29 |
spleen | 100% | 875.30 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 4.40 | 1 / 1 |
muscle | 99% | 387.23 | 791 / 803 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 98% | 5.94 | 44 / 45 |
heart | 97% | 521.79 | 838 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 89% | 584.68 | 823 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 88% | 4.21 | 70 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_1904108 | Biological process | protein localization to ciliary inversin compartment |
GO_0016055 | Biological process | Wnt signaling pathway |
GO_0090090 | Biological process | negative regulation of canonical Wnt signaling pathway |
GO_0097543 | Cellular component | ciliary inversin compartment |
GO_0005874 | Cellular component | microtubule |
GO_0005819 | Cellular component | spindle |
GO_0016020 | Cellular component | membrane |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0005516 | Molecular function | calmodulin binding |
GO_0005515 | Molecular function | protein binding |
Gene name | INVS |
Protein name | Inversin (Inversion of embryo turning homolog) (Nephrocystin-2) INVS protein |
Synonyms | INV NPHP2 |
Description | FUNCTION: Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). . |
Accessions | Q9Y283 ENST00000262457.7 [Q9Y283-1] Q2M1I4 ENST00000262456.6 [Q9Y283-2] ENST00000374921.3 [Q9Y283-3] |