NKD2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NKD2 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	5345.87	578 / 578	86%	16.04	992 / 1155
pancreas	87%	285.15	285 / 328	90%	15.69	161 / 178
intestine	91%	422.60	876 / 966	86%	26.23	455 / 527
esophagus	90%	560.97	1301 / 1445	79%	16.07	145 / 183
bladder	86%	492.71	18 / 21	73%	17.77	369 / 504
breast	73%	500.08	336 / 459	80%	9.85	890 / 1118
kidney	99%	627.81	88 / 89	49%	6.87	443 / 901
prostate	98%	817.79	240 / 245	41%	2.28	206 / 502
stomach	66%	212.00	238 / 359	67%	22.06	193 / 286
skin	74%	738.09	1332 / 1809	38%	3.69	178 / 472
brain	53%	172.40	1394 / 2642	58%	4.01	411 / 705
thymus	80%	305.57	520 / 653	29%	8.07	177 / 605
adrenal gland	99%	596.84	255 / 258	9%	0.57	21 / 230
uterus	35%	127.79	59 / 170	68%	17.34	311 / 459
ovary	27%	153.04	48 / 180	75%	12.83	323 / 430
spleen	100%	1878.06	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	23.79	1 / 1
tonsil	0%	0	0 / 0	93%	13.88	42 / 45
eye	0%	0	0 / 0	89%	7.58	71 / 80
liver	55%	181.15	124 / 226	31%	3.06	125 / 406
heart	78%	386.38	674 / 861	0%	0	0 / 0
adipose	50%	299.01	605 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	28%	1.10	8 / 29
blood vessel	16%	64.62	220 / 1335	0%	0	0 / 0
peripheral blood	8%	32.05	78 / 929	0%	0	0 / 0
muscle	2%	3.72	14 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0072659	Biological process	protein localization to plasma membrane
GO_0048210	Biological process	Golgi vesicle fusion to target membrane
GO_0032436	Biological process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0090090	Biological process	negative regulation of canonical Wnt signaling pathway
GO_0030178	Biological process	negative regulation of Wnt signaling pathway
GO_1903078	Biological process	positive regulation of protein localization to plasma membrane
GO_0006887	Biological process	exocytosis
GO_0010954	Biological process	positive regulation of protein processing
GO_0016055	Biological process	Wnt signaling pathway
GO_0070382	Cellular component	exocytic vesicle
GO_0005886	Cellular component	plasma membrane
GO_0031410	Cellular component	cytoplasmic vesicle
GO_0071944	Cellular component	cell periphery
GO_0016328	Cellular component	lateral plasma membrane
GO_0005737	Cellular component	cytoplasm
GO_0016323	Cellular component	basolateral plasma membrane
GO_0060090	Molecular function	molecular adaptor activity
GO_0032036	Molecular function	myosin heavy chain binding
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0019838	Molecular function	growth factor binding
GO_0051117	Molecular function	ATPase binding
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding

IV. Literature review

Gene name	NKD2
Protein name	Protein naked cuticle homolog 2 (Naked-2) (hNkd2)
Synonyms
Description	FUNCTION: Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells. .
Accessions	ENST00000274150.4 [Q969F2-2] ENST00000616539.4 [Q969F2-1] ENST00000610777.2 [Q969F2-2] Q969F2 ENST00000296849.10 [Q969F2-1]