TLE3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0016055Biological processWnt signaling pathway
GO_0120163Biological processnegative regulation of cold-induced thermogenesis
GO_0009887Biological processanimal organ morphogenesis
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_1990907Cellular componentbeta-catenin-TCF complex
GO_0005654Cellular componentnucleoplasm
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0003714Molecular functiontranscription corepressor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTLE3
Protein nameTransducin-like enhancer of split 3 splice variant 1
TLE family member 3, transcriptional corepressor
TLE family member 3, transcriptional corepressor (Transducin-like enhancer of split 3 short isoform)
Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3)
Transducin-like enhancer of split 3 splice variant 2
SynonymsKIAA1547
DescriptionFUNCTION: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). .

AccessionsQ6PRX2
ENST00000560525.6
H0YKN8
ENST00000559048.5 [Q04726-4]
H0YKH0
Q6PRX3
ENST00000557919.5
H0YNT2
ENST00000537387.2
H0YLI3
ENST00000559191.5
ENST00000558201.5
ENST00000559929.5
ENST00000557907.5 [Q04726-3]
H0YLW9
ENST00000557997.5 [Q04726-3]
H0YNI7
Q04726
H0YL70
ENST00000558379.5 [Q04726-6]
ENST00000451782.7 [Q04726-5]
H0YKH5
ENST00000558939.5 [Q04726-1]
ENST00000560939.5
ENST00000557984.6
Q672R2
ENST00000440567.7 [Q04726-7]
ENST00000317509.12 [Q04726-2]
ENST00000560589.5
H0YKT5
ENST00000561453.5