PTPRO | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
glutamatergic neuron	12 studies	54% ± 20%	Explore
oligodendrocyte precursor cell	12 studies	33% ± 10%	Explore
GABAergic neuron	9 studies	59% ± 19%	Explore
interneuron	6 studies	65% ± 16%	Explore
microglial cell	6 studies	24% ± 13%	Explore
retina horizontal cell	6 studies	53% ± 24%	Explore
podocyte	5 studies	90% ± 10%	Explore
macrophage	5 studies	23% ± 10%	Explore
neuron	4 studies	40% ± 17%	Explore
GABAergic interneuron	3 studies	54% ± 10%	Explore
astrocyte	3 studies	32% ± 20%	Explore
granule cell	3 studies	53% ± 17%	Explore
amacrine cell	3 studies	37% ± 29%	Explore
GABAergic amacrine cell	3 studies	54% ± 21%	Explore
OFF-bipolar cell	3 studies	54% ± 24%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	12 studies	44% ± 19%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	89%	1109.65	2363 / 2642	95%	5.18	671 / 705
kidney	93%	4790.20	83 / 89	63%	1.96	564 / 901
intestine	72%	485.59	696 / 966	67%	8.39	355 / 527
lung	97%	596.93	563 / 578	41%	1.10	478 / 1155
uterus	92%	695.96	156 / 170	14%	0.49	64 / 459
spleen	100%	508.39	241 / 241	0%	0	0 / 0
adrenal gland	63%	123.55	163 / 258	37%	1.59	84 / 230
bladder	67%	165.10	14 / 21	32%	3.44	163 / 504
blood vessel	96%	709.83	1278 / 1335	0%	0	0 / 0
adipose	85%	261.28	1026 / 1204	0%	0	0 / 0
stomach	25%	41.19	91 / 359	55%	8.25	158 / 286
breast	40%	87.03	182 / 459	32%	0.54	357 / 1118
peripheral blood	49%	168.28	456 / 929	0%	0	0 / 0
skin	25%	38.42	447 / 1809	20%	0.43	93 / 472
ovary	19%	36.16	34 / 180	21%	0.39	91 / 430
prostate	36%	58.16	87 / 245	1%	0.03	7 / 502
lymph node	0%	0	0 / 0	34%	0.66	10 / 29
esophagus	20%	33.62	291 / 1445	11%	0.92	20 / 183
pancreas	10%	16.96	33 / 328	19%	0.31	34 / 178
thymus	15%	26.98	100 / 653	5%	0.07	32 / 605
heart	13%	24.34	114 / 861	0%	0	0 / 0
liver	10%	16.01	23 / 226	3%	0.04	12 / 406
tonsil	0%	0	0 / 0	11%	0.17	5 / 45
muscle	5%	10.09	41 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	3%	0.04	2 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006470	Biological process	protein dephosphorylation
GO_0072112	Biological process	podocyte differentiation
GO_0030032	Biological process	lamellipodium assembly
GO_0090260	Biological process	negative regulation of retinal ganglion cell axon guidance
GO_0035335	Biological process	peptidyl-tyrosine dephosphorylation
GO_0090090	Biological process	negative regulation of canonical Wnt signaling pathway
GO_0003093	Biological process	regulation of glomerular filtration
GO_0050807	Biological process	regulation of synapse organization
GO_0010977	Biological process	negative regulation of neuron projection development
GO_0036060	Biological process	slit diaphragm assembly
GO_0003105	Biological process	negative regulation of glomerular filtration
GO_0032835	Biological process	glomerulus development
GO_0000902	Biological process	cell morphogenesis
GO_0002548	Biological process	monocyte chemotaxis
GO_1990264	Biological process	peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
GO_0010812	Biological process	negative regulation of cell-substrate adhesion
GO_0007411	Biological process	axon guidance
GO_0016324	Cellular component	apical plasma membrane
GO_0098978	Cellular component	glutamatergic synapse
GO_0098839	Cellular component	postsynaptic density membrane
GO_0005886	Cellular component	plasma membrane
GO_0043197	Cellular component	dendritic spine
GO_0016020	Cellular component	membrane
GO_0070062	Cellular component	extracellular exosome
GO_0043005	Cellular component	neuron projection
GO_0098982	Cellular component	GABA-ergic synapse
GO_0030426	Cellular component	growth cone
GO_0016328	Cellular component	lateral plasma membrane
GO_0030424	Cellular component	axon
GO_0030027	Cellular component	lamellipodium
GO_0005001	Molecular function	transmembrane receptor protein tyrosine phosphatase activity
GO_0017147	Molecular function	Wnt-protein binding
GO_0042803	Molecular function	protein homodimerization activity
GO_0045296	Molecular function	cadherin binding
GO_0016791	Molecular function	phosphatase activity
GO_0005515	Molecular function	protein binding
GO_0004725	Molecular function	protein tyrosine phosphatase activity

IV. Literature review

[source]

Gene name	PTPRO
Protein name	Receptor-type tyrosine-protein phosphatase O (R-PTP-O) (EC 3.1.3.48) (Glomerular epithelial protein 1) (Protein tyrosine phosphatase U2) (PTP-U2) (PTPase U2) protein-tyrosine-phosphatase (EC 3.1.3.48) Protein tyrosine phosphatase receptor type O
Synonyms	GLEPP1 PTPU2
Description	FUNCTION: Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function (By similarity). .
Accessions	ENST00000674188.1 ENST00000542557.5 [Q16827-4] H0YH11 A0A6I8PRG8 ENST00000674385.1 A0A6I8PU14 ENST00000674388.1 [Q16827-3] ENST00000535322.1 ENST00000544706.2 ENST00000674352.1 A0A6I8PIM6 ENST00000674261.1 [Q16827-1] ENST00000445537.6 [Q16827-3] A0A6I8PRB8 ENST00000544244.5 [Q16827-4] ENST00000281171.9 [Q16827-1] ENST00000674316.1 [Q16827-1] A0A6I8PS48 ENST00000674220.1 ENST00000543886.6 [Q16827-5] ENST00000674391.1 Q16827 ENST00000535311.5 H0YH60 ENST00000442921.7 [Q16827-3] A0A6I8PRZ5 ENST00000348962.7 [Q16827-2] ENST00000674286.1 A0A6I8PL17

PTPRO report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review