I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 4 studies | 22% ± 7% | |
| basal cell | 3 studies | 30% ± 1% | |
| connective tissue cell | 3 studies | 44% ± 31% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 4 studies | 22% ± 7% | |
| basal cell | 3 studies | 30% ± 1% | |
| connective tissue cell | 3 studies | 44% ± 31% |
Insufficient scRNA-seq data for expression of DKK1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| bladder | 100% | 1050.00 | 21 / 21 | 51% | 35.38 | 257 / 504 |
| prostate | 83% | 457.47 | 204 / 245 | 45% | 6.75 | 226 / 502 |
| skin | 87% | 14893.56 | 1581 / 1809 | 33% | 13.99 | 157 / 472 |
| ureter | 0% | 0 | 0 / 0 | 100% | 118.72 | 1 / 1 |
| lung | 40% | 98.92 | 231 / 578 | 55% | 25.84 | 636 / 1155 |
| esophagus | 20% | 120.45 | 291 / 1445 | 72% | 35.90 | 131 / 183 |
| breast | 59% | 321.05 | 272 / 459 | 25% | 8.88 | 277 / 1118 |
| uterus | 25% | 105.38 | 42 / 170 | 57% | 34.37 | 262 / 459 |
| pancreas | 0% | 0.45 | 1 / 328 | 78% | 34.65 | 138 / 178 |
| adipose | 74% | 1219.72 | 885 / 1204 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 44% | 9.47 | 20 / 45 |
| brain | 29% | 53.87 | 757 / 2642 | 15% | 5.60 | 109 / 705 |
| spleen | 44% | 59.15 | 106 / 241 | 0% | 0 | 0 / 0 |
| stomach | 15% | 25.23 | 53 / 359 | 29% | 14.19 | 82 / 286 |
| blood vessel | 39% | 81.11 | 516 / 1335 | 0% | 0 | 0 / 0 |
| intestine | 5% | 9.45 | 52 / 966 | 27% | 13.30 | 140 / 527 |
| liver | 4% | 5.41 | 8 / 226 | 25% | 26.52 | 102 / 406 |
| ovary | 17% | 76.67 | 30 / 180 | 4% | 0.79 | 18 / 430 |
| adrenal gland | 2% | 2.30 | 5 / 258 | 15% | 3.30 | 34 / 230 |
| kidney | 9% | 12.16 | 8 / 89 | 5% | 1.25 | 48 / 901 |
| thymus | 8% | 12.11 | 51 / 653 | 4% | 0.64 | 26 / 605 |
| heart | 11% | 23.89 | 95 / 861 | 0% | 0 | 0 / 0 |
| muscle | 3% | 6.38 | 26 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 3% | 0.13 | 2 / 80 |
| peripheral blood | 1% | 1.86 | 10 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0042662 | Biological process | negative regulation of mesodermal cell fate specification |
| GO_0030279 | Biological process | negative regulation of ossification |
| GO_1904723 | Biological process | negative regulation of Wnt-Frizzled-LRP5/6 complex assembly |
| GO_0060392 | Biological process | negative regulation of SMAD protein signal transduction |
| GO_0007611 | Biological process | learning or memory |
| GO_0030900 | Biological process | forebrain development |
| GO_0046330 | Biological process | positive regulation of JNK cascade |
| GO_0060173 | Biological process | limb development |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_0045813 | Biological process | positive regulation of Wnt signaling pathway, calcium modulating pathway |
| GO_0002090 | Biological process | regulation of receptor internalization |
| GO_0030514 | Biological process | negative regulation of BMP signaling pathway |
| GO_0051966 | Biological process | regulation of synaptic transmission, glutamatergic |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0090090 | Biological process | negative regulation of canonical Wnt signaling pathway |
| GO_0043523 | Biological process | regulation of neuron apoptotic process |
| GO_0060070 | Biological process | canonical Wnt signaling pathway |
| GO_2000726 | Biological process | negative regulation of cardiac muscle cell differentiation |
| GO_0030178 | Biological process | negative regulation of Wnt signaling pathway |
| GO_1905607 | Biological process | negative regulation of presynapse assembly |
| GO_0003129 | Biological process | heart induction |
| GO_0010977 | Biological process | negative regulation of neuron projection development |
| GO_0003170 | Biological process | heart valve development |
| GO_0001707 | Biological process | mesoderm formation |
| GO_0043066 | Biological process | negative regulation of apoptotic process |
| GO_2000096 | Biological process | positive regulation of Wnt signaling pathway, planar cell polarity pathway |
| GO_0030326 | Biological process | embryonic limb morphogenesis |
| GO_0098883 | Biological process | synapse pruning |
| GO_0003197 | Biological process | endocardial cushion development |
| GO_0001942 | Biological process | hair follicle development |
| GO_0042663 | Biological process | regulation of endodermal cell fate specification |
| GO_0032526 | Biological process | response to retinoic acid |
| GO_0001706 | Biological process | endoderm formation |
| GO_0033137 | Biological process | negative regulation of peptidyl-serine phosphorylation |
| GO_0090244 | Biological process | Wnt signaling pathway involved in somitogenesis |
| GO_0000902 | Biological process | cell morphogenesis |
| GO_1904338 | Biological process | regulation of dopaminergic neuron differentiation |
| GO_1904958 | Biological process | positive regulation of midbrain dopaminergic neuron differentiation |
| GO_0032091 | Biological process | negative regulation of protein binding |
| GO_0060325 | Biological process | face morphogenesis |
| GO_0061743 | Biological process | motor learning |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0031901 | Cellular component | early endosome membrane |
| GO_0039706 | Molecular function | co-receptor binding |
| GO_0008083 | Molecular function | growth factor activity |
| GO_0050750 | Molecular function | low-density lipoprotein particle receptor binding |
| GO_0048019 | Molecular function | receptor antagonist activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | DKK1 |
| Protein name | Dickkopf-like protein 1 Dickkopf-related protein 1 (Dickkopf-1) (Dkk-1) (hDkk-1) (SK) |
| Synonyms | UNQ492/PRO1008 |
| Description | FUNCTION: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 . DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease . Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (By similarity). . |
| Accessions | O94907 I1W660 ENST00000373970.4 |
