I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell of artery | 7 studies | 54% ± 13% | |
| GABAergic neuron | 3 studies | 30% ± 12% | |
| glutamatergic neuron | 3 studies | 26% ± 12% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell of artery | 7 studies | 54% ± 13% | |
| GABAergic neuron | 3 studies | 30% ± 12% | |
| glutamatergic neuron | 3 studies | 26% ± 12% |
Insufficient scRNA-seq data for expression of DKK2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 96% | 401.94 | 442 / 459 | 83% | 3.76 | 923 / 1118 |
| lung | 98% | 638.78 | 569 / 578 | 73% | 3.21 | 842 / 1155 |
| ovary | 71% | 130.52 | 127 / 180 | 70% | 2.61 | 299 / 430 |
| skin | 90% | 387.78 | 1633 / 1809 | 37% | 1.57 | 173 / 472 |
| thymus | 64% | 89.87 | 416 / 653 | 60% | 2.92 | 363 / 605 |
| intestine | 63% | 179.96 | 608 / 966 | 58% | 2.60 | 307 / 527 |
| prostate | 58% | 102.42 | 141 / 245 | 59% | 1.91 | 298 / 502 |
| esophagus | 31% | 34.44 | 442 / 1445 | 54% | 1.72 | 99 / 183 |
| pancreas | 3% | 2.01 | 9 / 328 | 81% | 3.57 | 144 / 178 |
| bladder | 24% | 32.62 | 5 / 21 | 52% | 2.05 | 261 / 504 |
| blood vessel | 74% | 166.53 | 987 / 1335 | 0% | 0 | 0 / 0 |
| stomach | 8% | 7.01 | 29 / 359 | 64% | 2.64 | 183 / 286 |
| adipose | 69% | 160.05 | 836 / 1204 | 0% | 0 | 0 / 0 |
| uterus | 28% | 60.75 | 47 / 170 | 33% | 2.20 | 150 / 459 |
| brain | 35% | 45.88 | 924 / 2642 | 22% | 0.93 | 158 / 705 |
| heart | 55% | 96.62 | 477 / 861 | 0% | 0 | 0 / 0 |
| muscle | 43% | 71.85 | 343 / 803 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 40% | 0.84 | 18 / 45 |
| adrenal gland | 21% | 25.63 | 54 / 258 | 10% | 0.35 | 23 / 230 |
| kidney | 9% | 7.94 | 8 / 89 | 17% | 0.45 | 152 / 901 |
| liver | 0% | 0.26 | 1 / 226 | 24% | 0.64 | 96 / 406 |
| spleen | 22% | 17.31 | 54 / 241 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 21% | 0.31 | 6 / 29 |
| eye | 0% | 0 | 0 / 0 | 3% | 0.04 | 2 / 80 |
| peripheral blood | 0% | 0.95 | 3 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0016055 | Biological process | Wnt signaling pathway |
| GO_0090263 | Biological process | positive regulation of canonical Wnt signaling pathway |
| GO_0090090 | Biological process | negative regulation of canonical Wnt signaling pathway |
| GO_0005615 | Cellular component | extracellular space |
| GO_0048019 | Molecular function | receptor antagonist activity |
| GO_0039706 | Molecular function | co-receptor binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | DKK2 |
| Protein name | Dickkopf homolog 2 (Xenopus laevis), isoform CRA_a (Dickkopf-2 variant) Dickkopf WNT signaling pathway inhibitor 2 Dickkopf-related protein 2 (Dickkopf-2) (Dkk-2) (hDkk-2) |
| Synonyms | hCG_19901 UNQ682/PRO1316 |
| Description | FUNCTION: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). . |
| Accessions | D6RGF1 ENST00000510463.1 ENST00000513208.5 Q9UBU2 D6RCC2 ENST00000285311.8 Q9H3R7 |
