NHERF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045198Biological processestablishment of epithelial cell apical/basal polarity
GO_0072659Biological processprotein localization to plasma membrane
GO_1903402Biological processregulation of renal phosphate excretion
GO_0097291Biological processrenal phosphate ion absorption
GO_0060088Biological processauditory receptor cell stereocilium organization
GO_0060158Biological processphospholipase C-activating dopamine receptor signaling pathway
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0030036Biological processactin cytoskeleton organization
GO_0070293Biological processrenal absorption
GO_0090660Biological processcerebrospinal fluid circulation
GO_0003096Biological processrenal sodium ion transport
GO_0007009Biological processplasma membrane organization
GO_0010766Biological processnegative regulation of sodium ion transport
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0045859Biological processregulation of protein kinase activity
GO_0007191Biological processadenylate cyclase-activating dopamine receptor signaling pathway
GO_0010761Biological processfibroblast migration
GO_0051683Biological processestablishment of Golgi localization
GO_2001244Biological processpositive regulation of intrinsic apoptotic signaling pathway
GO_0030033Biological processmicrovillus assembly
GO_0044782Biological processcilium organization
GO_0022612Biological processgland morphogenesis
GO_0045930Biological processnegative regulation of mitotic cell cycle
GO_0032782Biological processbile acid secretion
GO_0010642Biological processnegative regulation of platelet-derived growth factor receptor signaling pathway
GO_0007605Biological processsensory perception of sound
GO_0045199Biological processmaintenance of epithelial cell apical/basal polarity
GO_0002009Biological processmorphogenesis of an epithelium
GO_0070373Biological processnegative regulation of ERK1 and ERK2 cascade
GO_0007097Biological processnuclear migration
GO_0016055Biological processWnt signaling pathway
GO_0051939Biological processgamma-aminobutyric acid import
GO_0034635Biological processglutathione transport
GO_0030643Biological processintracellular phosphate ion homeostasis
GO_0150104Biological processtransport across blood-brain barrier
GO_0098739Biological processimport across plasma membrane
GO_0034767Biological processpositive regulation of monoatomic ion transmembrane transport
GO_0010764Biological processnegative regulation of fibroblast migration
GO_0065003Biological processprotein-containing complex assembly
GO_0051898Biological processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0008360Biological processregulation of cell shape
GO_0008361Biological processregulation of cell size
GO_0012505Cellular componentendomembrane system
GO_0071944Cellular componentcell periphery
GO_0005634Cellular componentnucleus
GO_0001726Cellular componentruffle
GO_0070062Cellular componentextracellular exosome
GO_0030175Cellular componentfilopodium
GO_0015629Cellular componentactin cytoskeleton
GO_0032426Cellular componentstereocilium tip
GO_0097225Cellular componentsperm midpiece
GO_0005902Cellular componentmicrovillus
GO_0016020Cellular componentmembrane
GO_0031528Cellular componentmicrovillus membrane
GO_0098797Cellular componentplasma membrane protein complex
GO_0005737Cellular componentcytoplasm
GO_0031526Cellular componentbrush border membrane
GO_0016324Cellular componentapical plasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0031982Cellular componentvesicle
GO_0042802Molecular functionidentical protein binding
GO_0043495Molecular functionprotein-membrane adaptor activity
GO_0005102Molecular functionsignaling receptor binding
GO_0017081Molecular functionchloride channel regulator activity
GO_0070851Molecular functiongrowth factor receptor binding
GO_0019902Molecular functionphosphatase binding
GO_0099103Molecular functionchannel activator activity
GO_0031800Molecular functiontype 3 metabotropic glutamate receptor binding
GO_0015185Molecular functiongamma-aminobutyric acid transmembrane transporter activity
GO_0050780Molecular functiondopamine receptor binding
GO_0045159Molecular functionmyosin II binding
GO_0030165Molecular functionPDZ domain binding
GO_0031698Molecular functionbeta-2 adrenergic receptor binding
GO_0044325Molecular functiontransmembrane transporter binding
GO_0031799Molecular functiontype 2 metabotropic glutamate receptor binding
GO_0005515Molecular functionprotein binding
GO_0044877Molecular functionprotein-containing complex binding
GO_0008013Molecular functionbeta-catenin binding

IV. Literature review

[source]
Gene nameNHERF1
Protein nameNHERF family PDZ scaffold protein 1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (Ezrin-radixin-moesin-binding phosphoprotein 50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1)
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1)
SynonymsSLC9A3R1
NHERF
DescriptionFUNCTION: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa. .

AccessionsJ3QRA3
ENST00000581356.1
ENST00000413388.2 [O14745-2]
ENST00000583369.5
ENST00000262613.10 [O14745-1]
O14745
J3QRP6