OTUD5 | OmnibusX

Name	Number of supported studies	Average coverage
endothelial cell	5 studies	19% ± 3%	Explore
epithelial cell	4 studies	32% ± 10%	Explore
B cell	3 studies	20% ± 5%	Explore
CD16-positive, CD56-dim natural killer cell, human	3 studies	18% ± 1%	Explore
innate lymphoid cell	3 studies	20% ± 3%	Explore
abnormal cell	3 studies	16% ± 1%	Explore
goblet cell	3 studies	19% ± 2%	Explore

Name	Number of supported studies	Average coverage
peripheral blood	3 studies	21% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	4699.96	1445 / 1445	100%	61.40	183 / 183
liver	100%	2621.09	226 / 226	100%	46.93	406 / 406
ovary	100%	5826.62	180 / 180	100%	79.81	430 / 430
pancreas	100%	2642.99	328 / 328	100%	71.76	178 / 178
prostate	100%	5854.10	245 / 245	100%	90.94	502 / 502
skin	100%	5065.59	1809 / 1809	100%	78.52	472 / 472
stomach	100%	3753.10	359 / 359	100%	67.75	286 / 286
thymus	100%	5844.49	653 / 653	100%	98.81	605 / 605
uterus	100%	5897.23	170 / 170	100%	78.80	459 / 459
brain	100%	5755.82	2641 / 2642	100%	95.67	705 / 705
lung	100%	5207.75	578 / 578	100%	66.99	1154 / 1155
kidney	100%	4699.67	89 / 89	100%	64.90	900 / 901
intestine	100%	5494.15	966 / 966	100%	69.85	526 / 527
bladder	100%	5073.76	21 / 21	100%	68.46	502 / 504
adrenal gland	100%	5321.65	258 / 258	100%	77.17	229 / 230
breast	100%	4840.64	459 / 459	100%	75.67	1113 / 1118
adipose	100%	4741.41	1204 / 1204	0%	0	0 / 0
blood vessel	100%	5032.92	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	69.67	80 / 80
lymph node	0%	0	0 / 0	100%	127.42	29 / 29
spleen	100%	7792.46	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	73.77	45 / 45
ureter	0%	0	0 / 0	100%	38.53	1 / 1
peripheral blood	100%	6062.07	928 / 929	0%	0	0 / 0
muscle	100%	2880.32	801 / 803	0%	0	0 / 0
heart	99%	2404.35	851 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0014033	Biological process	neural crest cell differentiation
GO_0032480	Biological process	negative regulation of type I interferon production
GO_0071108	Biological process	protein K48-linked deubiquitination
GO_0070536	Biological process	protein K63-linked deubiquitination
GO_1904263	Biological process	positive regulation of TORC1 signaling
GO_0006508	Biological process	proteolysis
GO_0090090	Biological process	negative regulation of canonical Wnt signaling pathway
GO_0032496	Biological process	response to lipopolysaccharide
GO_1904515	Biological process	positive regulation of TORC2 signaling
GO_0016579	Biological process	protein deubiquitination
GO_0005829	Cellular component	cytosol
GO_0005634	Cellular component	nucleus
GO_1990380	Molecular function	K48-linked deubiquitinase activity
GO_0101005	Molecular function	deubiquitinase activity
GO_0004843	Molecular function	cysteine-type deubiquitinase activity
GO_0061578	Molecular function	K63-linked deubiquitinase activity

Gene name	OTUD5
Protein name	ubiquitinyl hydrolase 1 (EC 3.4.19.12) (Deubiquitinating enzyme A) OTU domain-containing protein 5 (EC 3.4.19.12) (Deubiquitinating enzyme A) (DUBA)
Synonyms
Description	FUNCTION: Deubiquitinating enzyme that functions as a negative regulator of the innate immune system . Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains . Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro) . Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production . Controls neuroectodermal differentiation through cleaving 'Lys-48'-linked ubiquitin chains to counteract degradation of select chromatin regulators such as ARID1A, HDAC2 and HCF1 . Acts as a positive regulator of mTORC1 and mTORC2 signaling following phosphorylation by MTOR: acts by mediating deubiquitination of BTRC, leading to its stability . .
Accessions	ENST00000710076.1 [Q96G74-4] ENST00000376488.8 [Q96G74-5] Q96G74 ENST00000428668.2 [Q96G74-4] ENST00000710073.1 [Q96G74-5] ENST00000396743.7 [Q96G74-5] ENST00000156084.8 [Q96G74-1] ENST00000455452.5 H7BZQ3 ENST00000710072.1 [Q96G74-5] ENST00000710075.1 [Q96G74-1]

OTUD5 report